1. Sure: Delta has Not Only Evolved Antibody Resistance
    Nate Klingenstein Nate Klingenstein United States says:
    October 11, 2021 at 2:47 AM

    Antibodies can be infection-enhancing, non-neutralizing, or neutralizing.  This article describes one of the ways in which antibodies are infection-enhancing in SARS-CoV-2; it basically rides them into other immune cells to infect them and totally wreak havoc on the immune system once it does.  When infection-enhancing antibodies overwhelm neutralizing antibodies, clinical ADE occurs.

    Delta has already evolved complete resistance to neutralizing antibodies from vaccines targeting the NTD, one of two major targets for antibodies in SARS-CoV-2.  It has even evolved to enhance the activity of the infection-enhancing antibodies.

    Basically, the virus can abuse antibodies for its own benefit in multiple ways, not just dodge them.  Delta's doing that right now and here's (part of) how.

    Reply
    • So does this mean that a previous immune response will allow the variants
      192.168.0.13 192.168.0.13 Canada says:
      October 13, 2021 at 12:55 AM

      So does this mean that a previous immune response will allow the variants to infect for easily? If this is the case, how does the vaccine immune response compare to a natural infection immune response?

      Reply
      • In short, yes; that is certainly a possibility. There are studies that
        Anon Anon Anon Anon United States says:
        October 22, 2021 at 7:17 PM

        In short, yes; that is certainly a possibility.

        There are studies that can be searched that show Clinical ADE in animals when they tried to mRNA vaccinate them against viruses like SARS-CoV-2. Many of those studies showed high mortality rates of up to 85% or more.

        With the mRNA therapy, they send mRNA into your cells to program them to produce a certain antibody or a protein that will elicit your body to make an antibody against.

        With natural immunity, your body will produce many antibodies for different aspects of the virus including the different proteins on the surface of the envelope and the features of the capsid, and it will do it in a natural way that will reduce the risk of ADE.

        Reply
The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment
(Logout)
Post

Terms

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

Provide Feedback