Too many US doctors think large, expensive studies must be done to show the worth of a supplement.  But where's the money and what's the need?  Smaller studies done at universities combines well with your own personal experience.  Small study showed that HA + fish oil + glucosamine + chondroitin taken twice / day was very helpful to OA joint pain sufferers.  I was about to schedule hip replacement surgery, decided to wait and tried this combination.  Took the supplements religiously twice / day.  My hip pain decreased 90%.  I did not schedule surgery.  That was 3+ years ago.  I don't expect to ever need it.