The assumption that it is elevated lipid levels that cause heart disease has fundamental flaws. The ability of cholesterol lowering, at least with statins, to reduce mortality is not established according to thennt.com, and the NNT for even reducing the number of non-fatal heart attacks  in five years is 104! Halving lipid levels ought to do much better than that if lipids are so deadly!

I, too, like Mr. Brown, have FH. My "bad" LDL level for the last 10 years has been over 500mg/dl, and yet, at age 70, my coronary arteries continue to be completely free of any calcification (by EBCT). So here are two individuals with extreme lipid profiles; one has heart problems and one has no problems at all. Why, after 50 years of "research", does the medical community have no meaningful explanation for the differences? And why, after 50 years, is the medical research community still completely uninterested in studying those of that appear to exceptions to the standard paradigm?