New cancer classification system may revolutionize diagnoses and treatments. Cancers may be classified by their primary site of origin or by their histological or tissue types or even by their genetic and molecular types. Human cancer classification is currently based on the idea of cell of origin, light and electron microscopic attributes of the cancer. Recent innovative techniques in biology have provided a wealth of information on iron-metabolism-changes in cancerous cells. Future cancer treatment may be advanced by using an iron model of cancer classification. Cancer encompasses a class of heterogeneous diseases that differ on a cellular and molecular level - even within subtype. Rather than gradually collecting many tiny mutations, cancerous cells can dramatically acquire macromutations (large genomic leaps, tens or even hundreds of structural rearrangements in genomic regions). The mechanisms of chromothripsis (chromosome shattering) are not well understood if microbiological information (cancer occurs when cellular iron overload affects DNA, RNA, chromosomes, even mitoses) is ignored. If cancer encompasses a class of local/regional iron-overload diseases (pancreatic cancer - local iron overload in the cells in the pancreas; lung cancer - local iron overload in the cells in the lung), most cancers can be adequately treated with surgical procedures and iron-chelating therapies (direct intratumoral injections of antiiron agents, blood donation and iron-poor diet).