I think everyone here would acknowledge the fact that mouse models of Alzheimer have miserably failed at finding out treatments effective in humans. With a drug failure rate in clinical trials over 99%. The primary concern of a clinician should be the predictive power of the model,the same concern applied when making medical diagnoses. I  see too few of all those things in the article.Instead of putting the focus on shifting towards human relevant research capable of predicting human response to drugs and disease, the vast majority  of clinicians community still trusts a failed research paradigm. What should patients be supposed to think about this?