Would you want to know early on, even though there is no cure? Or would you prefer to remain ignorant and let nature takes it's course? I think there are valid arguments on both sides and ultimately it is really a personal choice. What I find interesting about this breakthrough (and others like it) is that by identifying early stage patients, the science community is able to conduct studies with them and learn. Those studies could lead to developing a cure in the future. There is a huge lack of data to work with today. I would volunteer to be part of a study that could potentially help future generations find a cure to such a horrible disease.