More essential than essential?

Opinion

... in response to Widespread SARS-CoV-2 mutation escapes vaccine- and infection-induced CD8 T-cell responses

More essential than essential?

Phil Ip says:

October 5, 2021 at 1:45 AM

Hi Nate - thanks for your insights. As a layman with only a few years of life sciences, I'm looking to ask someone a fundamental question: is it possible the mutation in P272L was merely from Proline unavailability and Leucine was "grabbed" during replication? I know Leucine is an essential amino and Proline is synthesized from various glutamates, BUT if competition for Proline (perhaps due to an mRNA vaccine being given to a silently infected covid patient, as we know covid-19 impairs mitochondrial dyanmics) existed in even certain tissues/cells, could that not force the mutation?

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