There is some good evidence that this is an important part of cell repair.  Less calories work. How you do this is an open question. 2 days a week for about 20 hours of zero calories seems to change IGF and other important factors.  It would be interesting to see exactly how long calorie restriction needs to be before the repairs start.

Other things that do this is vigorous exercise-interval type.  Then there is the idea of our bowel bacteria and how they may regulate an overactive immune system. Water soluble fibers, low meat - sugar diets.

The mitochondria are a key to dysfunction and there are some supplements that help. B3, K2, NAC,  and the above ideas improve these important organelles.