1. Nitric Oxide may be the underlying mechanism for BCG mediated protection against SARS
    Shawn Green Shawn Green United States says:
    September 22, 2021 at 5:06 PM

    This study further confirms the merits of BCG and the importance of route of administration to render a non-specific protective response.  Furthermore, the likely mechanism is nitric oxide as previously predicted.  In studies when evaluated for nitric oxide, it was found that BCG triggers cytokine-dependent, IFN-γ and TNF-α and/or IL1-β, inducible nitric oxide synthase pathways (NOS) expression and nitric oxide release by both alveolar macrophages and non-immune cells, including airway epithelial cells.   www.medpagetoday.com/.../86410

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