1. Tom Hennessy on MGH researchers find how metformin drug prevents progression of pancreatic cancer
    Tom Hennessy Tom Hennessy Canada says:
    January 25, 2016 at 11:22 AM

    Metformin is thought to target iron.

    "Does metformin improve polycystic ovary syndrome symptoms through reduction in body iron stores? "

    Coincidentally, targeting iron results in the same, "reductions in a metastasis-associated change in cellular characteristics called epithelial to mesenchymal transition (EMT) and in the overall level of metastasis.", mentioned in the article.

    "iron chelation can target the AKT, ERK, JNK, p38, STAT3, TGF-β, Wnt and autophagic pathways to subsequently inhibit cellular proliferation, the epithelial-mesenchymal transition (EMT) and metastasis"

    Is Metformin merely mimicking iron reduction or is it an out and out iron chelator?

    Reply
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