Precision of targeting is only one factor influencing the clinical effects of tDCS. Equally or more important are effects on tracts and areas of the brain distant from the stimulation site. A 2 electrode montage may produce less specific but more robust clinical responses.

Although the most effective protocols are probably yet to be developed. Current protocols already demonstrate clinical benefit. For example, a 2 electrode montage using a 20-minute daily treatment for 5 days was shown to reduce fibromyalgia pain by 50% 7 years ago.

Select clinics provide tDCS therapy for conditions which respond, including fibromyalgia, migraine, CRPS and treatment-resistant uni- and bi-polar depression. There is also an option for home-use for appropriate patients. The fact that tDCS has no side effects and is easy to do permits at-home use.