Opinion

... in response to Phytocannabinoids
  1. Fundamentally Flawed Article
    Donna Evans Donna Evans Canada says:
    August 12, 2015 at 10:11 AM

    Dr Mandal mistakenly states:

    "Phytocannabinoids are cannabinoids that occur naturally in the cannabis plant".  

    This implies that phytocannabinoids cannot be found in plants outside the cannabis species.

    The most relevant phytocannabinoid identified to date - in terms of therapeutic actions in the body - is found in many plants, including the essential oil of the cannabis plant.  It is called: beta-caryophyllene.

    At the time of posting this comment, beta-caryophyllene is the only known selective agonist of the CB2 receptor and does not produce psychoactive effects.  By the way, CBD (cannabidiol) is a weak agonist of both CB1 and CB2 and science increasingly believes that CBD's therapeutic actions are not via the cannabinoid receptors.

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