1. As someone with great interest in the mechanisms of prolonged 5-7 day
    Leslie Estes Leslie Estes United States says:
    March 15, 2024 at 7:33 PM

    As someone with great interest in the mechanisms of prolonged 5-7 day fasting, I'd like to thank you for this great summary.

    I didn't see any mention of something else that was reported in the study, which might or might not be significant: "extreme changes in the brain-specific extracellular matrix protein tenascin-R". Could you possibly summarize this?

    Also, I wondered about the meaning of your paragraph, copied below... Is this a beneficial or adverse outcome/effect of prolonged fasting?

    RE: "The most highly connected proteins with weight trajectories while fasting include pulmonary surfactant-associated protein D (SFTPD) and interleukin-7 receptor (IL7R). Both of these proteins have essential roles in immunity and are associated with severe illness due to coronavirus disease 2019 (COVID-19)."

    Thank you again!

    Reply
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