Professor Price - You missed some important things.  Oxygen therapy, oximeters, Vitamin D for starters.  I could go on and on seeing I have very severe COPD and have been on oxygen for 8 years.  Without early intervention with oxygen I would have died long ago from pulmonary hypertension.   I have also had stem cell treatment which has also kept me alive. Attitudes have to change about COPD.  I am not Alpha One but my sister and I both have very severe COPD and were under age 50 when diagnosed.  Our grandmother and her father also had it.  What needs to be found are the genes that cause degradation of our lungs while others remain unchanged from smoking.  In my own family there are two siblings who smoked for decades yet have normal lung function.