1. Re: Multaq dose for Asian males (Japanese)?
    Grant Hieshima, MD Grant Hieshima, MD United States says:
    February 13, 2010 at 11:02 PM

    I have seen several references that say "However, based on a cross study comparison, following a single dose administration (400mg), Asian males (Japanese) have about a 2-fold higher exposure than Caucasian males.  The pharmacokinetics of dronedarone in other races has not been assessed."  Is there any rationale to decrease the dose in Asian males (Japanese)?  Does this difference reflect a genetic difference in Liver enzymes such as CYP3A4?  Is there a greater inhibition of the enzyme or possibly a relative deficiency of enzyme function in this population?   Is there any literature addressing these questions?

    Reply
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