Neurodegeneration is known as a neurological disorder that comes with developing atrophy and irreversible damage of neurons. Two of the most common neurodegenerative diseases are Parkinson’s (PD) and Alzheimer’s (AD).

The growth factors that are responsible for the survival, maintenance, and regeneration of specific neurons are NGF, GDNF, and BDNF. Such growth factors make them therapeutics for neurodegenerative diseases.

Reagents for therapeutic targets of neurodegenerative diseases

Figure 1. Neuron Specificity. Image Credit: Sino Biological Inc

Clinical trials of NGF (therapeutic choice for AD), GDNF (treatment for PD), and BDNF (therapeutic target for both AD and PD) are ongoing.

Furthermore, therapies targeting neurotrophic factors and related receptors can also be a successful method for the less common neurodegenerative diseases like amyotrophic lateral sclerosis (ALS), Huntington’s (HD), and Rett Syndrome.

Neurotrophins and Receptors

Neurotrophins are known as growth factors crucial for neuron development, maintenance, and survival. Four neurotrophin family members are available: BDNF, NGF, neurotrophin 3, and neurotrophin 4.

They have the potential to bind to particular Trk receptors with high affinity and p75NTR with low affinity. This is done to evoke neurotrophic or pro-apoptotic signaling. NGF binds to TrkA; BDNF and neurotrophin 4 bind to TrkB; neurotrophin 3 binds to TrkC. BDNF, NGF, and all the receptors are known as targets for therapy in AD. Also, for PD, BDNF is a therapeutic choice.

NGF (Nerve growth factor)

In the neurotrophin family, NGF is known to be the first discovered member. It is crucial in the survival, growth, and maintenance of particular kinds of neurons.

Reagents for therapeutic targets of neurodegenerative diseases

Image Credit: Sino Biological Inc

Human NGF protein

11050-HNAC

Purity: >95%

Expressed Host: CHO Stable Cells

Activity: Cell proliferation assay can be performed with the help of TF-1 human erythroleukemic cells

BDNF (Brain-derived neurotrophic factor)

BDNF aids the existence and maintenance of sensory neurons, retinal ganglia, spinal motor neurons, a few cholinergic neurons, and some dopaminergic neurons.

Reagents for therapeutic targets of neurodegenerative diseases

Image Credit: Sino Biological Inc

Mouse BDNF protein

50240-BDNF Protein

Purity: >95%

Expressed Host: HEK293 Cells

Neurotrophin 3/NT3

Human NT3 Protein

10286-HNAE

Purity: >90%

Expressed Host: E. coli

Activity: Binding ability in a functional ELISA, binds to human TrkB

Reagents for therapeutic targets of neurodegenerative diseases

Image Credit: Sino Biological Inc

Neurotrophin 4/NT4

Human NT4 Protein

10265-HNAE

Purity: >95%

Expressed Host: HEK293 Cells

Trk receptors

Source: Sino Biological Inc

Cat# Molecule Species Expressed Host Purity Tag Activity
11073-H03H TrkA Human HEK293 Cells >98% C-hFc & His Active
11073-H07E1 TrkA Human E. coli >97% N-His Active
51103-M02H TrkA Mouse HEK293 Cells >90% C-hFc Active
51103-M08H TrkA Mouse HEK293 Cells >95% C-His Active
70101-D01H TrkA Canine HEK293 Cells >90% N-hFc Active
70101-D07H TrkA Canine HEK293 Cells >95% N-His Active
80404-R02H TrkA Rat HEK293 Cells >95% C-hFc Active
80404-R08H TrkA Rat HEK293 Cells >95% C-His Active
10047-H03H TrkB Human HEK293 Cells >90% C-hFc & His Active
10047-H08H TrkB Human HEK293 Cells >97% C-His Active
50132-M08H TrkB Mouse HEK293 Cells >98% C-His Active
70035-D08H TrkB Canine HEK293 Cells >95% C-His Active
80243-R08H TrkB Rat HEK293 Cells >95% C-His Active
10048-H03H TrkC Human HEK293 Cells >98% C-hFc & His Active
10048-H08H TrkC Human HEK293 Cells >95% C-His Active
50320-M08H TrkC Mouse HEK293 Cells >95% C-His Active

 

Low affinity common receptor to neurotrophins: p75NTR

Human p75NTR Protein

13184-H02H

Purity: >95%

Expressed Host: HEK293 Cell

Activity: Inhibit NGF-dependent proliferation of TF-1 human erythroleukemic cells, ED50 is 0.5-3 μg/mL in the presence of 4 ng/mL Recombinant Human NGF.

Mouse p75NTR Protein

50971-M02H

Purity: >90%

Expressed Host: HEK293 Cell

Activity: Inhibit NGF-dependent proliferation of TF-1 human erythroleukemic cells. ED50 is 0.5-3 μg/mL in the presence of 2 ng/mL Recombinant mouse NGF.

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