Tumor necrosis factors (TNFs) and their corresponding receptors (TNFRs) play crucial roles in regulating the immune system. Dysregulation of TNFs/TNFRs is closely linked to tumorigenesis, progression, invasion, and metastasis. Thus, there has been an upsurge of interest in targeting TNFs/TNFRs for cancer immunotherapy in recent years.
The FDA has approved five medicines that target BCMA for myeloma as of January 2024. An antibody-drug conjugate (ADC) targeting CD30, Brentuximab vedotin, has also been approved by the FDA to specifically target mesenchymal large-cell lymphoma and Hodgkin's lymphoma.
TNFs also frequently target TNFRs such as 4-1BB, Fas/CD95, and GITR, while other targets include RANKL, TRAIL, BLys, and CD40L. Drugs that target these TNFs/TNFRs are either authorized for clinical use already or are undergoing clinical trials.
Sino Biological offers a comprehensive selection of recombinant TNF and TNFR proteins and corresponding antibodies that support drug discovery and development research on TNFs/TNFRs.
TNF receptor superfamily targeted therapy in cancer
TNFRSF molecules and ligands are targeted on cells of the immune system to boost immune activity against a tumor cell or on tumor cells to either directly promote apoptotic cell death or focus cytotoxic mechanisms toward a tumor cell.
Image Credit: Sino Biological Inc.
Featured recombinant TNF and TNFR proteins
Human TNF-alpha protein
SPR assay: Captured Adalimumab on Anti-human IgG Fc via CM5 Chip binds to TNF-α with an affinity constant of 0.2843 nM. Image Credit: Sino Biological Inc.
Human RANKL/TNFSF11 protein
SEC-MALS-validated: The purity was more than 90% and the molecular weight is around 74.5 kDa (Routinely tested). Image Credit: Sino Biological Inc.
Human BCMA protein
ELISA: Immobilized human TNFRSF17/BCMA protein can bind human Fc-BAFF/Biotin protein (Cat#: 10056-H01H). Image Credit: Sino Biological Inc.
Human 4-1BB/CD137 protein
ELISA: Immobilized human 4-1BB-His protein can bind human 4-1BBL-hFc protein (Cat#: 15693-H01H). Image Credit: Sino Biological Inc.
Featured TNF and TNFR antibodies
CD120a/TNFRSF1A neutralizing antibody
Cat#: 10872-R111
Applications
Human TNFRSF1A monoclonal antibody neutralizes human TNFα activity induced by human TNFRSF1A. Image Credit: Sino Biological Inc.
Anti-TNF-alpha antibody, rabbit mAb
Cat#: 10602-R101
Applications
Flow cytometric analysis of Human TNF-α expression on human peripheral blood lymphocytes. Image Credit: Sino Biological Inc.
More TNF and TNFR products
- TNF-α
- CD40L
- OX40L
- CD70/CD27L
- RANKL
- 4-1BBL
- LIGHT
- CD120a/b
- CD40
- OX40
- CD27
- RANK
- 4-1BB/CD137
- HVEM
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