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Pirfenidone significantly reduces a marker of heart muscle scarring

Patients with heart failure with preserved ejection fraction who took the antifibrotic drug pirfenidone saw a significant reduction in a marker of heart muscle scarring compared with patients who received a placebo, based on findings from an early-phase trial presented at the American College of Cardiology's 70th Annual Scientific Session.

18 May 2021

New technology tricks tumors to eliminate itself through the production of anti-cancer agents

Scientists at the University of Zurich have modified a common respiratory virus, called adenovirus, to act like a Trojan horse to deliver genes for cancer therapeutics directly into tumor cells. Unlike chemotherapy or radiotherapy, this approach does no harm to normal healthy cells.

18 May 2021

Hyperinvasive approach is an effective treatment strategy for out-of-hospital cardiac arrest

A subgroup of patients who experienced an out-of-hospital cardiac arrest (OHCA) that did not respond to standard advanced cardiac life support (ACLS), were immediately transported to a cardiac care center, and placed on a device similar to a heart-lung bypass machine were more likely to have survived with good brain function six months later than similar patients who received standard care at the site where the OHCA occurred.

18 May 2021

Rivaroxaban reduces the occurrence of severe ischemic events in patients with peripheral artery disease

Rivaroxaban, in addition to low-dose aspirin, significantly reduced the occurrence of total severe events of the heart, limb or brain and issues related to other vascular complications in patients with symptomatic peripheral artery disease (PAD) who underwent lower extremity revascularization, a procedure to open blocked arteries in the leg.

17 May 2021

Nanotechnology and COVID-19 diagnosis and treatment

The development of nano-biosensors and nanoparticle-based vaccines and medicines has opened a new path toward better management of the coronavirus disease 2019 (COVID-19) pandemic. In a recently published article in the journal ACS Biomaterials Science & Engineering, scientists have reviewed recent advancements in nanotechnology-based diagnostic and therapeutic interventions against human coronaviruses.

17 May 2021

New framework could help manage COVID-19, deal with other major stresses

A new analysis of the effects of SARS-CoV-2, the virus causing the current pandemic, on the human body has provided novel insights into the nature of resilience and how we deal with stressful situations.

17 May 2021

New method provides greater quality control and safety of heparin drug

A new method to analyze the blood thinning drug Heparin has been developed that can pinpoint contaminants more accurately and quickly, providing greater quality control and safety.

17 May 2021

Study suggests potential role for probiotics in preventing respiratory infections

Daily probiotic use was associated with fewer upper respiratory symptoms in overweight and older people, according to a study that suggests a potential role for probiotics in preventing respiratory infections.

14 May 2021

Novel nanotechnology could change the lives of people living with cystic fibrosis

World-first nanotechnology developed by the University of South Australia could change the lives of thousands of people living with cystic fibrosis (CF) as groundbreaking research shows it can improve the effectiveness of the CF antibiotic Tobramycin, increasing its efficacy by up to 100,000-fold.

13 May 2021

Study reports new monoclonal antibodies with broad neutralizing capabilities against betacoronaviruses (including SARS-CoV-2)

In a paper published on the bioRxiv* preprint server, researchers report new monoclonal antibodies that target the S2 subunit and that have broad neutralization activity against several betacoronaviruses.

13 May 2021

Black fungus complicates India's COVID pandemic

India faces a global health crisis as the number of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections reaches over 23.7 million. As India's health system buckles with increased admissions and a lack of resources, another health threat has emerged.

13 May 2021

International experts are working to provide evidence-based guidelines for radiation therapy dosing for children

Annually, more than 350,000 children in the world are affected by pediatric cancer. Radiation has improved outcomes dramatically, but the damage caused to healthy tissue can affect the long-term health of a child.

13 May 2021

Study reveals genes that cause loss of lung function in active smokers

Chronic Obstructive Pulmonary Disease (COPD) is a disease caused by cigarette smoking that reduces lung function and causes difficulty breathing. It is the third leading cause of death worldwide. Current treatments for COPD only affect symptoms, not progression. Identifying who is going to get COPD before they get it is key to figuring out how to intercept the disease at an early stage.

12 May 2021

Researchers develop novel targeted therapy for triple-negative breast cancer

Researchers from Hong Kong Baptist University (HKBU), in collaboration with Cornell University, have developed a novel targeted therapy for triple-negative breast cancer (TNBC) that uses a specially-designed nano-carrier to deliver the Chinese medicine compound gambogic acid (GA).

12 May 2021

Fungal disease is emerging among hundreds of COVID-19 patients in India, shows study

Authorities scramble to provide drugs to treat a fungal disease affecting India's COVID-19 patients. A fungal disease called mucormycosis is emerging among hundreds of COVID-19 patients in India, placing further strain on hospitals already at breaking point.

12 May 2021

New study shows that COVID-19 vaccines are safe in pregnancy

A new Northwestern Medicine study of placentas from patients who received the COVID-19 vaccine during pregnancy found no evidence of injury, adding to the growing literature that COVID-19 vaccines are safe in pregnancy.

12 May 2021

An intranasal COVID-19 vaccine elicits long-lasting immunity against SARS-CoV-2 variants in vivo

A team of scientists from the Washington University School of Medicine and the University of Texas Medical Branch, USA, has recently evaluated the durability and robustness of an adenovirus-vectored, spike-based intranasal COVID-19 vaccine in mice.

11 May 2021

Researchers design compounds that prevent SARS-CoV-2 entry in human lung cells

Researchers have designed a new class of TMPRSS2 inhibitors that have shown broad antiviral activity against coronaviruses, including the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

11 May 2021

AI methods predict COVID-19 patient outcomes using routine clinical data from ICUs

The investigators used machine learning to predict which patients might get worse and not respond positively to being turned onto their front in intensive care units (ICUs) - a technique known as proning that is commonly used in this setting to improve oxygenation of the lungs.

11 May 2021

Severe COVID-19 linked to genetic clotting predisposition

Thus, the need to stratify the risk of severe or critical disease in patients presenting with SARS-CoV-2 infection remains a crying necessity. A new preprint research paper posted to the medRxiv server discusses the relationship between severe disease and pre-existing susceptibility to clots and other diseases of the cardiovascular system.

11 May 2021

Lungs News and Research

Pirfenidone significantly reduces a marker of heart muscle scarring

New technology tricks tumors to eliminate itself through the production of anti-cancer agents

Hyperinvasive approach is an effective treatment strategy for out-of-hospital cardiac arrest

Rivaroxaban reduces the occurrence of severe ischemic events in patients with peripheral artery disease

Nanotechnology and COVID-19 diagnosis and treatment

New framework could help manage COVID-19, deal with other major stresses

New method provides greater quality control and safety of heparin drug

Study suggests potential role for probiotics in preventing respiratory infections

Novel nanotechnology could change the lives of people living with cystic fibrosis

Study reports new monoclonal antibodies with broad neutralizing capabilities against betacoronaviruses (including SARS-CoV-2)

Black fungus complicates India's COVID pandemic

International experts are working to provide evidence-based guidelines for radiation therapy dosing for children

Study reveals genes that cause loss of lung function in active smokers

Researchers develop novel targeted therapy for triple-negative breast cancer

Fungal disease is emerging among hundreds of COVID-19 patients in India, shows study

New study shows that COVID-19 vaccines are safe in pregnancy

An intranasal COVID-19 vaccine elicits long-lasting immunity against SARS-CoV-2 variants in vivo

Researchers design compounds that prevent SARS-CoV-2 entry in human lung cells

AI methods predict COVID-19 patient outcomes using routine clinical data from ICUs

Severe COVID-19 linked to genetic clotting predisposition

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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