Immune System News and Research

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CAR T-cell therapy produces impressive results in first clinical trial in patients with multiple myeloma

A therapy made of immune system T cells engineered to target a somewhat enigmatic cell protein called GPRC5D antigen produced impressive results in its first clinical trial in patients with multiple myeloma, researchers at Memorial Sloan Kettering Cancer Center (MSK), Dana-Farber Cancer Institute and Roswell Park Comprehensive Cancer Center report in a new study published today by the New England Journal of Medicine.

29 Sep 2022

Omega-3 fatty acids can stimulate active healing of inflammation in cases of severe COVID-19

Intravenous treatment with omega-3 fatty acids in elderly hospitalized patients in intensive care due to COVID-19 seems to have positive effects on the ability of the immune system to cope with the virus, according to a study from Karolinska Institutet in Sweden.

29 Sep 2022

Study examines the incidence of severe COVID-19 in fully vaccinated and boosted high-risk populations

In new research, scientists studied a cohort of patients at the U.S Veterans Health Administration facilities to determine the incidence of severe COVID-19 outcomes among individuals with primary and booster doses of any combination of BNT162b2, mRNA-1273, and Ad26.COV2.S vaccines.

29 Sep 2022

UAB study finds distinct kidney resident macrophage subpopulations located in spatially discrete microenvironments

Macrophages are immune cells that engulf and digest pathogens, cancer cells or cellular debris. The kidneys -; like other tissues in the body -; contain kidney resident macrophages, or KRMs, from the time of birth.

28 Sep 2022

Insights into the biology of virtual memory CD8+ T cells

Virtual memory CD8+ T cells (TVM) are a relatively recent discovery in humans. A new review discusses what is known about them from mouse models and their cellular equivalents in humans, as described in the peer-reviewed Journal of Interferon & Cytokine Research.

28 Sep 2022

UArizona researchers discover new protein that is responsible for controlling cell growth in yeasts

Like bacteria, yeasts are found everywhere, even in and around our bodies. And, as with bacteria, you can become infected by yeasts and become ill. Yeasts infect about 150 million people a year and kill about 1.7 million, especially those who are immunocompromised.

28 Sep 2022

Shape-shifting mitochondria influence Th17 cells’ propensity for autoimmune activity

A new study focused on the immune system's Th17 cells suggests that the shape and function of their mitochondria (the powerhouse of cells) is important in autoimmune and inflammatory disorders, such as multiple sclerosis.

28 Sep 2022

Study suggests the immune system may benefit from a measure of stress

Stress has been linked to all sorts of serious health issues, from insomnia to high blood pressure, obesity and even heart disease. But it's generally acknowledged that some stress can also be helpful, like when someone's chasing a work deadline.

28 Sep 2022

Live imaging and cellular barcoding reveal how new stem cells are vetted for quality

Using live imaging and cellular barcoding, researchers in the Stem Cell Program at Boston Children's Hospital have glimpsed how new stem cells -; in this case, blood stem cells -; are vetted for quality soon after they're born.

28 Sep 2022

Study finds dimethyl fumarate was not associated with an improvement in clinical outcomes in adults hospitalized with COVID-19

Researchers evaluated the efficacy of the anti-inflammatory drug dimethyl fumarate in treating COVID-19 as part of an early phase, randomized, controlled assessment trial in the UK.

28 Sep 2022

One-time test predicts which hospitalized COVID-19 patients are likely to worsen, study finds

A one-time test could predict which people hospitalized with COVID-19 are likely to worsen significantly during their stay, even if they were admitted with relatively mild symptoms, according to a study of more than 2,500 people headed by researchers at Stanford Medicine.

27 Sep 2022

Food, vaccines, bacteria, and viruses may all prime our immune system to attack SARS-CoV-2

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causal agent of the ongoing coronavirus disease 2019 (COVID-19) pandemic, primarily causes mild to moderate upper-respiratory tract illness. However, some individuals with COVID-19 develop severe infections and require hospital admission.

27 Sep 2022

Giving immunotherapy before targeted therapy improves survival in patients with advanced melanoma

A clinical trial led by clinicians at Georgetown Lombardi Comprehensive Cancer Center showed a remarkable 20 percent advantage in the two-year overall survival rate for people with advanced melanoma who first received immunotherapy (72 percent survival rate) versus those who initially got targeted therapies (52 percent survival rate).

27 Sep 2022

How the gut microbiome could affect COVID-19 severity

Researchers review the potential role of the gut microbiome in determining severe COVID-19.

27 Sep 2022

Spectroscopy reveals a high abundance of microplastics in human placenta

Scientists have used a spectroscopy technique to identify and characterize microplastics in the human placenta. The study published in the journal Science of The Total Environment provides a detailed overview of the size, shape, and nature of microplastics found in the placenta.

27 Sep 2022

High-tech lab in Nigeria could be a game changer in tackling emerging and re-emerging diseases

Nigeria's Oligo synthesizer laboratory, the first in West Africa, could be a game changer in tackling emerging and re-emerging diseases in the region if harnessed to its full potential, laboratory scientists have said.

27 Sep 2022

Leducq Foundation awards $15 million to advance the understanding of atherosclerosis

The Leducq Foundation has awarded $15 million to researchers at UVA Health and their collaborators to advance our understanding of atherosclerosis, or hardening of the arteries, and find better ways to treat it. Diseases linked to atherosclerosis are the leading cause of death in the United States.

27 Sep 2022

Some pre-existing conditions matter a lot more when assessing COVID-19 outcomes

A new paper in Biology Methods & Protocols, published by Oxford University Press, indicates that some pre-existing conditions-;including degenerative neurological diseases, dementia, and severe disabilities-;matter a lot more than once thought when assessing who is at risk for death due to COVID-19.

27 Sep 2022

Transplantation tolerance associated with conventional T cells’ susceptibility to Treg suppression

Patients who receive organ transplants must take powerful medications to prevent the immune system from rejecting the organ.

27 Sep 2022

Researchers uncover a new way the immune system detects coronavirus infection

In a recent study posted to bioRxiv*, researchers in the United States demonstrated that the main protease (Mpro) of coronaviruses (CoVs) activates host inflammasome responses.

27 Sep 2022

Immune System News and Research

CAR T-cell therapy produces impressive results in first clinical trial in patients with multiple myeloma

Omega-3 fatty acids can stimulate active healing of inflammation in cases of severe COVID-19

Study examines the incidence of severe COVID-19 in fully vaccinated and boosted high-risk populations

UAB study finds distinct kidney resident macrophage subpopulations located in spatially discrete microenvironments

Insights into the biology of virtual memory CD8+ T cells

UArizona researchers discover new protein that is responsible for controlling cell growth in yeasts

Shape-shifting mitochondria influence Th17 cells’ propensity for autoimmune activity

Study suggests the immune system may benefit from a measure of stress

Live imaging and cellular barcoding reveal how new stem cells are vetted for quality

Study finds dimethyl fumarate was not associated with an improvement in clinical outcomes in adults hospitalized with COVID-19

One-time test predicts which hospitalized COVID-19 patients are likely to worsen, study finds

Food, vaccines, bacteria, and viruses may all prime our immune system to attack SARS-CoV-2

Giving immunotherapy before targeted therapy improves survival in patients with advanced melanoma

How the gut microbiome could affect COVID-19 severity

Spectroscopy reveals a high abundance of microplastics in human placenta

High-tech lab in Nigeria could be a game changer in tackling emerging and re-emerging diseases

Leducq Foundation awards $15 million to advance the understanding of atherosclerosis

Some pre-existing conditions matter a lot more when assessing COVID-19 outcomes

Transplantation tolerance associated with conventional T cells’ susceptibility to Treg suppression

Researchers uncover a new way the immune system detects coronavirus infection

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