Metabolite News and Research

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Metabolites are the intermediates and products of metabolism. The term ''metabolite'' is usually restricted to small molecules.

Study reveals genomic regions that could help understand obesity

A new study has helped to shine light on the genetic pathways underlying obesity. The findings could help develop more personalized ways to help people maintain a healthy weight.

11 Jan 2022

New insights into how red meat-rich diet increases cardiovascular disease risk

A Cleveland Clinic-led study has revealed new insights into how a diet rich in red meat increases risk for cardiovascular disease. The findings were published in Nature Microbiology and build on more than a decade of research by lead author Stanley Hazen, MD, PhD.

23 Dec 2021

Study suggests nitazoxanide fails to reduce the severity of SARS-CoV-2

A new study shows that the optimization of nitazoxanide formulations may allow the review of the potential use of the drug for the treatment of SARS-CoV-2 infection.

22 Dec 2021

Succinate receptor can be a potential target for cancer treatment

Cancer cells show unchecked rapid growth beyond tissue boundaries that is no longer stopped by normal control mechanisms. Due to this rapid growth, the metabolism of cancer cells is altered compared to that of cells that grow normally.

18 Dec 2021

Introducing the PhysioMimix™ OOC Multi-Organ Microphysiological System

CN Bio, a leading developer of single and multi-organ microphysiological systems (MPS), otherwise known as organ-on-a-chip (OOC), today announced the commercial launch of its new PhysioMimix™ OOC Multi-Organ MPS.

From CN-Bio 1 Dec 2021

Study on molnupiravir precursor NHC antiviral activity against SARS-CoV-2 variants of concern

In a new study, published on the bioRxiv* preprint server, scientists aimed to determine the reaction of the molnupiravir parent drug (NHC) to different SARS-CoV-2 Variants of Concern (VoCs). They also sought to establish the therapeutic window in a human lung cell model.

29 Nov 2021

Monitoring cellular metabolism for NAFLD/NASH liver disease research

In this interview, Jolanta Vidugiriene, a Senior Research Scientist at Promega Corporation, talks to News-Medical about tools for studying metabolism in NAFLD/NASH research.

From Promega Corporation 22 Nov 2021

GABA secreted by B-cells blunts the body's cytotoxic T-cell-based response to tumors

A group of scientists led by researchers from the RIKEN Center for Integrative Medical Sciences have discovered that B-cells, a type of immune cell, secrete the neurotransmitter GABA, and also found that the GABA secreted by the B-cells promoted the emergence of anti-inflammatory macrophages, blunting the body's cytotoxic T-cell-based response to tumors.

21 Nov 2021

Study reveals mechanism by which vitamin D reduces inflammation caused by immune cells

Scientists recently gained insights into how vitamin D functions to reduce inflammation caused by immune cells that might be relevant to the responses during severe COVID-19. In a study jointly published by Purdue University and the National Institutes of Health, scientists do just that.

18 Nov 2021

Research expands the general understanding of transcription process in bacteria

Bacteria need to constantly adapt to compete against other species for nutrient sources and to survive against threats such as antibiotics and toxins.

15 Nov 2021

Drug combination highly effective in children with standard- and high-risk acute promyelocytic leukemia

A clinical trial has found that the combination of all-trans retinoic acid, which is a metabolite of vitamin A, and arsenic trioxide is highly effective in children with standard- and high-risk acute promyelocytic leukemia, or APL.

11 Nov 2021

Hemin as a potential therapy for COVID-19

The current study explores the antiviral activity of HO-1 induced by hemin against SARS-CoV-2 and attempts to describe the mechanism of its anti-viral action.

8 Nov 2021

Researchers identify a single protein that balances sugar and fat metabolism in the liver

Keeping everything running smoothly inside the human body is a tricky business that involves a multitude of checks and balances to make sure that an exquisite equilibrium is maintained.

2 Nov 2021

Researchers identify an important mediator of thrombosis in CKD patients

Researchers have identified a potential new signaling pathway and enzyme that may help further the understanding of blood clot formation in chronic kidney disease patients and ultimately be targeted for therapeutic purposes.

1 Nov 2021

Alteration in gut microbiome may lead to hyperinflammation in severe COVID-19

A team of international scientists has recently identified a distinct set of proinflammatory mediators and metabolites associated with the fatal consequences of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Moreover, they have established a link between gut microbiome alteration and hyper-inflammatory response in patients with severe COVID-19. The study is currently available on the bioRxiv* preprint server.

1 Nov 2021

A novel approach to improve the stability of Remdesivir

A recent study discusses a novel method to enhance the stability of Remdesivir.

28 Oct 2021

Diet-associated molecules in the gut are linked with aggressive prostate cancer

Cleveland Clinic researchers have shown for the first time that diet-associated molecules in the gut are associated with aggressive prostate cancer, suggesting dietary interventions may help reduce risk. Findings from the study were published in Cancer Epidemiology, Biomarkers & Prevention.

28 Oct 2021