Metabolite News and Research

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Metabolites are the intermediates and products of metabolism. The term ''metabolite'' is usually restricted to small molecules.

Role of S-acylation in SARS-CoV-2 infectivity

A new study published in Developmental Cell investigates S-acylation of the SARS-CoV-2 S protein.

10 Oct 2021

New technology shows great promise for early diagnosis of Alzheimer’s disease

A technology developed by scientists at Lawrence Berkeley National Laboratory (Berkeley Lab) shows great promise for diagnosing Alzheimer's disease before symptoms arise, potentially changing the course of research and treatment for this condition, which affects millions of people worldwide and is estimated to be the sixth leading cause of death in the United States.

7 Oct 2021

Scientists identify a new method to treat triple-negative breast cancer

A team of clinicians and scientists from the National Cancer Centre Singapore (NCCS), Singapore General Hospital (SGH) and A*STAR's Genome Institute of Singapore (GIS) has identified a novel method to treat triple-negative breast cancer (TNBC). They discovered that cancer cells switch between different cell states and are able to change from being less aggressive ('epithelial') to being more aggressive ('mesenchymal'), and vice versa.

7 Oct 2021

Enisamium shows potential as antiviral therapy for COVID-19

Researchers studied the effect of enisamium on the growth and proliferation of Caco-2 and normal human bronchial epithelial cells.

6 Oct 2021

Study finds cause and solution for complications in peritoneal dialysis

The number of patients suffering from chronic kidney disease or loss of kidney function is increasing worldwide and with it the number of people who need renal replacement therapy.

4 Oct 2021

Buck Institute receives $14 million NIH grant to focus on one of the major drivers of aging

Buck Institute professors Judith Campisi, PhD and Lisa Ellerby PhD, have been awarded a $14.3 million grant from the NIH's National Institute of Aging to study cellular senescence, one of the major hallmarks of aging, as a driver of Alzheimer's disease and other age-related dementias.

29 Sep 2021

Long-held theory of cancer-induced immune suppression requires revision, study says

Many cancers produce an enzyme called IDO that suppresses immune system activity, but the long-held hypothesis of how this mechanism operates requires revision, according to a study published in Clinical Cancer Research.

29 Sep 2021

Researchers uncover a molecular mechanism to inhibit aggravation of colitis

The intestinal microbial ecosystem includes diverse species of bacteria. These bacteria can produce bioactive metabolites that directly affect the host's immune system.

21 Sep 2021

Drug accumulation alters gut bacterial metabolism and composition

In a research paper recently published in the journal Nature by Klünemann et al. (September 8th, 2021), the interaction of 15 diverse drugs with 25 common strains of gut bacteria is investigated, revealing 70 bacteria-drug interactions that include 29 entirely novel mechanisms not yet reported.

15 Sep 2021

Researchers disprove natural antioxidant urate for slowing the progression of Parkinson’s disease

The hypothesis that raising the brain levels of the natural antioxidant urate could slow the progression of Parkinson's disease (PD) has been disproven by researchers at Massachusetts General Hospital.

14 Sep 2021

Metabolic and immune markers as tools for risk stratification and monitoring in COVID-19

In a new study posted to the medRxiv* server scientists from Weil Cornell University and Stony Brook University in New York attempted to identify the metabolic and immune markers associated with severe COVID-19 disease using high-throughput targeted nuclear magnetic resonance (NMR) spectroscopy and high-dimensional flow cytometry. This will facilitate risk stratification, monitoring, and therapeutic interventions in COVID-19 patients.

14 Sep 2021

Study reveals blood metabolites associated with dementia

Scientists in Japan have identified metabolic compounds within the blood that are associated with dementia.

12 Sep 2021

Researchers uncover underlying metabolic changes that are linked to COVID-19 severity

COVID-19 patients have differing immune responses that lead to disease outcomes ranging from asymptomatic SARS-CoV-2 infection to death.

6 Sep 2021

New low-cost technique helps profile dynamic metabolic features from single isogenic cells

Researchers with the Single-Cell Center, Qingdao Institute of Bioenergy and Bioprocess Technology of the Chinese Academy of Sciences, have developed a fast, low-cost and high-throughput technique capable of profiling dynamic metabolic features from just one isogenic sample of cells.

1 Sep 2021

Discovery of new urinary biomarkers can boost the surveillance of synthetic drug abuse

A team of researchers from the National University of Singapore has come up with a new solution to boost the surveillance of designer drug abuse.

30 Aug 2021

Study reveals how high dietary fructose increases rates of obesity and cancers

Eating fructose appears to alter cells in the digestive tract in a way that enables it to take in more nutrients, according to a preclinical study from investigators at Weill Cornell Medicine and NewYork-Presbyterian.

18 Aug 2021

Link between high-fat diet, gut microbiota and cardiovascular disease revealed

A high-fat diet disrupts the biology of the gut's inner lining and its microbial communities -; and promotes the production of a metabolite that may contribute to heart disease, according to a study published Aug. 13 in the journal Science.

12 Aug 2021

Could a plant metabolite in liverworts be a potent antiviral against SARS-CoV-2 and other RNA viruses?

A new study from the National Centre for Biotechnology and Medicinal Chemistry Institute suggests Mother Nature delivered — in the form of liverworts. They found that the bryophyte Marchantia polymorpha, also known as umbrella liverworts, could work as a potential antiviral treatment.

5 Aug 2021

Women say California insurer makes it too hard to get drug for postpartum depression

When Miriam McDonald decided she wanted to have another baby at age 44, her doctor told her she had a better chance of winning the lottery. So when she got pregnant right away, she and her husband were thrilled. But within three days of giving birth to their son, in September 2019, everything shifted.

28 Jul 2021

Scientists identify an antiviral metabolite as a potential serum biomarker for SARS-CoV-2 infection

Scientists from the UK have recently identified an antiviral metabolite 3'-Deoxy-3',4'-didehydro-cytidine as a potential serum biomarker to diagnose active severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The study is currently available on the medRxiv* preprint server while awaiting peer review.

27 Jul 2021