Antibodies News and Research

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Small study suggests a mix-and-match COVID-19 booster produces robust antibody levels

In a small study published in the medRxiv* preprint server, people given a booster Johnson & Johnson COVID-19 shot showed elevated and robust antibody levels.

19 Aug 2021

SARS-CoV-2 antibodies found to neutralize bat coronavirus (RaTG13) in new study

A striking new study examines how far antibodies elicited by vaccines against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), or by natural infection, can neutralize the closely related bat coronavirus (CoV) RaTG13.

19 Aug 2021

How does the SARS-CoV-2 Delta variant’s spike drive membrane fusion and immunity evasion?

A fascinating and timely new study shows how the Delta variant of the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) achieved higher transmissibility and resistance to neutralization.

19 Aug 2021

Durable highly protective T cell response to AAV-spike vaccine against COVID-19 pneumonia in mice

New research, available as a preprint on the bioRxiv* server, has focused on the role played by T cell immunity, particularly CD8+ cytotoxic T cells, on preventing lethal infection with SARS-CoV-2 in mice infused with peptide-loaded antigen-presenting dendritic cells (DCs).

19 Aug 2021

Early clinical trial data in for whole virus COVID-19 vaccine candidate

In a study uploaded to the preprint server medRxiv*, the efficacy of a whole virion Coronavirus vaccine was determined by giving the vaccine to healthy adult volunteers, which generated a robust immune response with evidence of T-cell activation.

19 Aug 2021

Scientists identify a potent neutralizing nanobody against SARS-CoV-1

In a recently published article in the journal Virologica Sinica, scientists have described the development and validation of a potent nanobody that targets the receptor-binding domain (RBD) of severe acute respiratory syndrome coronavirus (SARS-CoV). The nanobody efficiently and specifically blocks the interaction between RBD and angiotensin-converting enzyme 2 (ACE2) and neutralizes the virus.

19 Aug 2021

White-tailed deer are highly susceptible to SARS-CoV-2 infection

The SARS-CoV-2 virus has been shown to infect a wide range of animals naturally and experimentally, and prior studies indicate deer are susceptible to infection. White-tailed deer (Odocoileus virginianus) fawns have been found to be susceptible to SARS-CoV-2.

19 Aug 2021

SARS-CoV-2 vaccine efficacy is strongly correlated with antibody neutralization levels

All COVID-19 vaccines appear less effective when faced with variants such as Delta, according to a new medRxiv* study. However, the researchers suggest that booster shots may help improve immunity and protect against symptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

18 Aug 2021

Scientists identify the main components driving amyloid beta-associated synapse degeneration

Healthy adult brains are endowed with a vast number of synapses, structures that relay signals across nerve cells to enable communications, information processing and storage throughout the nervous system.

18 Aug 2021

Videos capture the inexorable spread of SARS-CoV-2 in live animals

Video images capture for the first time in live animals the inexorable spread of the COVID-19 virus, tracking the infection as it moved from the noses of mice to the lungs and other organs over the course of six days, in a new study led by researchers at Yale and Université de Montréal.

18 Aug 2021

Convalescent plasma does not benefit high-risk COVID-19 outpatients with early symptoms, study shows

The final results of the Clinical Trial of COVID-19 Convalescent Plasma in Outpatients (C3PO) demonstrate that COVID-19 convalescent plasma did not prevent disease progression in a high-risk group of outpatients with COVID-19, when administered within the first week of their symptoms.

18 Aug 2021

The White House says boosters for all. Here’s what you need to know.

The Biden administration announced plans Wednesday to offer boosters to all U.S. adults as soon as next month, saying that recent data, including some made available only in the past few days, played a role in that decision.

18 Aug 2021

Study examines prevalence of neutralizing antibodies to HCoV-NL63 in healthy adults in Australia

A new study has been published in the MPDI journal Viruses, which focuses on determining the seroprevalence of neutralizing antibodies against HCoV-NL63, in healthy adults, in a cross-sectional study.

18 Aug 2021

How do glycans affect SARS-CoV-2 spike protein openings?

In a paper recently uploaded to the bioRxiv* preprint server, the role of glycan coating on the SARS-CoV-2 spike protein is further investigated by molecular dynamics simulations of the glycosylated and non-glycosylated protein, identifying several key glycans that play a role in stabilizing and protecting the RBD, and also encourage bonding with the ACE2 receptor.

18 Aug 2021

Study examines the prevalence of SARS-CoV-2 antibodies in Geneva, Switzerland

In a paper uploaded to the preprint server medRxiv*, antibodies against both the spike protein and nucleocapsid proteins of SARS-CoV-2 are measured in over 3,000 volunteers, six months following the initiation of the vaccination scheme in Geneva, Switzerland.

18 Aug 2021

Rush to boosters sparks confusion, differing recommendations

When the Food and Drug Administration announced last week that a third dose of Moderna or Pfizer-BioNTech covid-19 vaccine may boost the immunity of some people who are immunocompromised, officials repeated their stance that fully vaccinated, healthy people do not need another dose.

18 Aug 2021

Specificity of serological assays against SARS-CoV-2 in patients with parasitic infections

A new study available on the pre-print server medRxiv* aims to assess the specificity of the serological assays of SARS-CoV-2 antibodies among patients known to have a tissue-borne parasitic infection or those who reside in areas where the virus is endemic.

18 Aug 2021

Naive B cells could be useful for predicting vaccination response in immunocompromised

A recent study conducted at the Medical University of Graz, Austria, has revealed that the number of naïve B cells in the blood could independently predict the magnitude of immune response induced by coronavirus disease 2019 (COVID-19) vaccines in immunocompromised patients. The study is currently available on the medRxiv* preprint server.

17 Aug 2021

Delta variant unable to evade antibodies elicited by COVID-19 vaccination, finds study

Despite causing a surge in infections this summer that has resulted in thousands of hospitalizations and deaths, the delta variant of the virus that causes COVID-19 is not particularly good at evading the antibodies generated by vaccination, according to a study by researchers at Washington University School of Medicine in St. Louis.

17 Aug 2021

Study explores the role of nasal bacteria and provides clues to developing better flu, COVID-19 vaccines

While gut microbiota play a critical role in the induction of adaptive immune responses to influenza virus infection, the role of nasal bacteria in the induction of virus-specific adaptive immunity is less clear.

17 Aug 2021

Antibodies News and Research

Small study suggests a mix-and-match COVID-19 booster produces robust antibody levels

SARS-CoV-2 antibodies found to neutralize bat coronavirus (RaTG13) in new study

How does the SARS-CoV-2 Delta variant’s spike drive membrane fusion and immunity evasion?

Durable highly protective T cell response to AAV-spike vaccine against COVID-19 pneumonia in mice

Early clinical trial data in for whole virus COVID-19 vaccine candidate

Scientists identify a potent neutralizing nanobody against SARS-CoV-1

White-tailed deer are highly susceptible to SARS-CoV-2 infection

SARS-CoV-2 vaccine efficacy is strongly correlated with antibody neutralization levels

Scientists identify the main components driving amyloid beta-associated synapse degeneration

Videos capture the inexorable spread of SARS-CoV-2 in live animals

Convalescent plasma does not benefit high-risk COVID-19 outpatients with early symptoms, study shows

The White House says boosters for all. Here’s what you need to know.

Study examines prevalence of neutralizing antibodies to HCoV-NL63 in healthy adults in Australia

How do glycans affect SARS-CoV-2 spike protein openings?

Study examines the prevalence of SARS-CoV-2 antibodies in Geneva, Switzerland

Rush to boosters sparks confusion, differing recommendations

Specificity of serological assays against SARS-CoV-2 in patients with parasitic infections

Naive B cells could be useful for predicting vaccination response in immunocompromised

Delta variant unable to evade antibodies elicited by COVID-19 vaccination, finds study

Study explores the role of nasal bacteria and provides clues to developing better flu, COVID-19 vaccines

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