Bioinformatics News and Research

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Bioinformatics is the application of information techniques for the storage, retrieval, and analysis of large quantities of biological data.

NIH program provides a real-time risk assessment of variants of SARS-CoV-2

Faculty from the Departments of Microbiology, Medicine Genetics and Genomic Sciences, and Pathology and Molecular Cell-Based Medicine at the Icahn School of Medicine at Mount Sinai play key roles in a National Institutes of Health (NIH) program set up to provide a real-time risk assessment of variants of SARS-CoV-2, the virus that causes COVID-19. The program, called SARS-CoV-2 Assessment of Viral Evolution (SAVE) and described in a paper published March 31 in Nature, assesses how the variants might affect transmission, virulence, and resistance to both disease-induced (convalescent) and vaccine-induced immunity.

31 Mar 2022

New project launched to explore how GI microbiota may contribute to neurodegeneration

Alzheimer's disease (AD) is a type of dementia that affects memory, thinking and behavior. According to the Alzheimer's Association, an estimated 6.2 million Americans are living with this progressive neurologic disorder, and it is the sixth-leading cause of death in the U.S.

31 Mar 2022

A bioinformatics approach for detecting SARS-CoV-2 co-infections

Researchers discuss a novel bioinformatics-based method for the detection of SARS-CoV-2 co-infections with the Delta and Omicron variants.

29 Mar 2022

Researchers report progress en route to developing a hypoallergenic cat

Researchers at InBio (formerly Indoor Biotechnologies), a biotech company in Virginia, report progress en route to developing a hypoallergenic cat – or at least treating patients with allergies to the domestic cat – in a new article published online in The CRISPR Journal.

29 Mar 2022

Impact of truncated open reading frame 8 protein variants of SARS-CoV-2

A new study identified unique truncated open reading frame 8 proteins among SARS-CoV-2 sequences.

25 Mar 2022

New SARS-CoV-2 Omicron-Delta recombinant virus identified in the US

Researchers reported a novel SARS-CoV-2 Omicron and Delta recombinant virus in the United States.

24 Mar 2022

Study uncovers a gene that strongly associates with breast cancer patient's treatment outcomes

A multidisciplinary team of researchers from Roswell Park Comprehensive Cancer Center and Kaiser Permanente Northern California have identified the first pharmacogenomic marker for anthracyclines and HER2-targeting drugs, two commonly used breast cancer chemotherapies.

23 Mar 2022

Researchers aim to study the underlying pathophysiology of diastolic heart failure

Of the estimated five million patients in the U.S. diagnosed with heart failure annually, nearly half will have heart failure with preserved ejection fraction (HFpEF). Also known as diastolic heart failure, HFpEF occurs when the heart's lower left chamber loses its ability to relax and fill up with enough blood in between in each heartbeat.

23 Mar 2022

Using a new data-driven approach to understand more about people with Type 1 diabetes

An interdisciplinary team of researchers from the University of Missouri, Children's Mercy Kansas City and Texas Children's Hospital has used a new data-driven approach to learn more about persons with Type 1 diabetes, who account for about 5-10% of all diabetes diagnoses.

21 Mar 2022

New computational approach creates spatial maps of single-cell data within tissues

A new computational approach developed by researchers at The University of Texas MD Anderson Cancer Center successfully combines data from parallel gene-expression profiling methods to create spatial maps of a given tissue at single-cell resolution.

21 Mar 2022

AI system can help detect the degree and severity of heart transplant rejection

Heart transplantation can be a lifesaving operation for patients with end-stage heart failure. However, many patients experience organ transplant rejection, in which the immune system begins attacking the transplanted organ.

21 Mar 2022

Epigenetic changes could be a biomarker for early detection of type 1 diabetes

Children who develop type 1 diabetes show epigenetic changes in the cells of their immune system already before the antibodies of the disease are detected in their blood.

16 Mar 2022

Identification of linear B cell epitopes in the SARS-CoV-2 proteome that are conserved in humans coronaviruses

Researchers identified and validated multiple linear B-cell epitopes in the SARS-CoV-2 proteomes conserved in humans coronaviruses.

15 Mar 2022

Can wearables transform the future of healthcare?

In partnership with SLAS 2022, we spoke to Professor Michael Snyder about his latest research that investigates wearables and their future within healthcare.

From Society for Laboratory Automation and Screening (SLAS) 14 Mar 2022

Molecular signature of microorganisms in stool samples could predict pancreatic cancer risk

Pancreatic cancer is not one of the most frequently diagnosed cancers, but it is one of the most lethal due to its early local extension and metastatic behavior.

9 Mar 2022

Single protein elicits multilineage reprogramming of astrocytes in adult mouse brains

A single protein can reverse the developmental clock on adult brain cells called astrocytes, morphing them into stem-like cells that produce neurons and other cell types, UT Southwestern researchers report in a PNAS study.

9 Mar 2022

Scientists predict structure of SARS-CoV-2 frameshifting pseudoknot

Researchers recently unveiled the structure of programmed -1 ribosomal frameshifting pseudoknot of SARS-CoV-2.

8 Mar 2022

Study uncovers new clues about the cellular processes that can lead to androgen deficiency

A laboratory study at the Miller School of Medicine's Desai Sethi Urology Institute has uncovered new clues about the cellular processes that can lead to deficiencies of androgens (male hormones) such as testosterone.

4 Mar 2022

Study finds how genetic baggage can accumulate in the genomes of normal and mutant animals

You are probably familiar with the term that some people carry "a lot of extra baggage." Usually that term refers to that person's emotional history, but in genetics and our genomes, "extra baggage" can also describe the transposons lurking in our genomes, a historical record of our genomes surviving traumatic invasions during evolution.

4 Mar 2022

Biophysical fitness profile of SARS-CoV-2 Delta variant

In a recent study posted to the bioRxiv* preprint server, researchers investigated the biophysical fitness landscape of the receptor-binding domain (RBD) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant.

1 Mar 2022

Bioinformatics News and Research

Further Reading

NIH program provides a real-time risk assessment of variants of SARS-CoV-2

New project launched to explore how GI microbiota may contribute to neurodegeneration

A bioinformatics approach for detecting SARS-CoV-2 co-infections

Researchers report progress en route to developing a hypoallergenic cat

Impact of truncated open reading frame 8 protein variants of SARS-CoV-2

New SARS-CoV-2 Omicron-Delta recombinant virus identified in the US

Study uncovers a gene that strongly associates with breast cancer patient's treatment outcomes

Researchers aim to study the underlying pathophysiology of diastolic heart failure

Using a new data-driven approach to understand more about people with Type 1 diabetes

New computational approach creates spatial maps of single-cell data within tissues

AI system can help detect the degree and severity of heart transplant rejection

Epigenetic changes could be a biomarker for early detection of type 1 diabetes

Identification of linear B cell epitopes in the SARS-CoV-2 proteome that are conserved in humans coronaviruses

Can wearables transform the future of healthcare?

Molecular signature of microorganisms in stool samples could predict pancreatic cancer risk

Single protein elicits multilineage reprogramming of astrocytes in adult mouse brains

Scientists predict structure of SARS-CoV-2 frameshifting pseudoknot

Study uncovers new clues about the cellular processes that can lead to androgen deficiency

Study finds how genetic baggage can accumulate in the genomes of normal and mutant animals

Biophysical fitness profile of SARS-CoV-2 Delta variant

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