Phenotype News and Research

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Study finds memory B cell clones harbor the capacity to adopt multiple and functionally different fates in COVID-19 patients

Researchers examined single clones of SARS-CoV-2-specific memory B cells to understand their adaptability and fate.

13 Oct 2022

Age plays a more important role than genetics in affecting gene expression profiles as we get older

Amid much speculation and research about how our genetics affect the way we age, a University of California, Berkeley, study now shows that individual differences in our DNA matter less as we get older and become prone to diseases of aging, such as diabetes and cancer.

7 Oct 2022

NEI researchers create a high-resolution map of retinal cell chromatin contract points

National Eye Institute researchers mapped the organization of human retinal cell chromatin, the fibers that package 3 billion nucleotide-long DNA molecules into compact structures that fit into chromosomes within each cell's nucleus.

7 Oct 2022

Study using human and animal-derived cell lines suggests human origin of SARS-CoV-2 Omicron variant

Researchers examined the replicative capacity of seven SARS-CoV-2 isolates in 17 cell lines to understand their phenotypic variations and host range.

7 Oct 2022

Acute kidney injury in hospitalized COVID-19 patients

In a new study, researchers examined the phenotypes of acute kidney injury (AKI) in hospitalized coronavirus disease 2019 (COVID-19) patients.

7 Oct 2022

Multiomic comparison shows a reduction in circulating monocytes correlated with persistent post-COVID-19 pulmonary fibrosis

In a new study, researchers identified distinguishing immune features of coronavirus disease 2019 (COVID-19) in patients with late-resolving pulmonary fibrosis (LR COVID-PF) and early-resolving (ER COVID-PF).

4 Oct 2022

Insights into the biology of virtual memory CD8+ T cells

Virtual memory CD8+ T cells (TVM) are a relatively recent discovery in humans. A new review discusses what is known about them from mouse models and their cellular equivalents in humans, as described in the peer-reviewed Journal of Interferon & Cytokine Research.

28 Sep 2022

Study suggests the immune system may benefit from a measure of stress

Stress has been linked to all sorts of serious health issues, from insomnia to high blood pressure, obesity and even heart disease. But it's generally acknowledged that some stress can also be helpful, like when someone's chasing a work deadline.

28 Sep 2022

NIH launches new program to better understand the function of every human gene

The National Institutes of Health is launching a program to better understand the function of every human gene and generate a catalog of the molecular and cellular consequences of inactivating each gene.

27 Sep 2022

Does leptin play a role in Parkinson’s disease?

Scientists review in vitro and in vivo evidence associated with Parkinson's disease and leptin.

26 Sep 2022

Common germline variants of APOE contribute to differential COVID-19 outcomes

Researchers investigated the relationship between APOE4 genotype and COVID-19 outcomes using genetic models of mice.

26 Sep 2022

New mechanistic insights on the origin of SARS-CoV-2-induced neurological disorders

Researchers explored the effect of SARS-CoV-2 exposure on the brain.

20 Sep 2022

Research examines the roles of cytokines during SARS-CoV-2 infection in rhesus macaques

In a recent study posted to the bioRxiv* preprint server, researchers in the United States assessed the role of two cytokines, interferon-gamma (IFN-γ) and interleukin-10 (IL-10), in regulating immune cell responses and inflammation early during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in rhesus macaques.

18 Sep 2022

Research reveals pivotal role of C/EBPb in the development of alveolar macrophages

If a secretion in the lungs’ alveoli is not cleared regularly, breathing difficulties can develop. In a study published in Science Immunology, a team led by Alexander Mildner and Achim Leutz has now explained the pivotal role of the transcription factor C/EBPb in this process.

16 Sep 2022

STRATAGEM aims to provide new perspectives on multidrug-resistant solid tumors

Achieving a good efficacy of chemotherapy is one of the major challenges still unresolved in oncological patients. The main limitation to the efficacy of chemotherapy is the multidrug-resistant (MDR) phenotype, a multiple cross-resistance towards different anticancer drugs.

14 Sep 2022

Walnut consumption early on in life may lead to better health as we age

Researchers who reviewed 20 years of diet history and 30 years of physical and clinical measurements have found participants who ate walnuts early on in life showed a greater likelihood for being more physically active, having a higher quality diet, and experiencing a better heart disease risk profile as they aged into middle adulthood.

14 Sep 2022

The kinetics of T cell response, the inflammatory profile, and the pox-specific T cell induction in monkeypox infection

A new study describes the changes in immune T cell profile over time following monkeypox infection.

14 Sep 2022

Mucosal vaccination triggers superior T cell response against SARS-CoV-2 variants

In a recent study posted to the bioRxiv* server, researchers in Singapore and the United States demonstrated that intranasal (I.N.) delivery of a mucosal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination triggered a superior T cell response compared to an equivalent dose of antigen delivered by the subcutaneous (S.C.) route.

12 Sep 2022

A direct side-by-side comparison of all available COVID-19 vaccines

In a recent study posted to the medRxiv* preprint server, researchers assessed immune responses to homologous and heterologous coronavirus disease 2019 (COVID-19) vaccine combinations among Córdoba, Spain residents.

11 Sep 2022

How a key brain network responds to seasonal shifts in day length

A recent paper examined the difference in neuronal communication in the hypothalamic network that regulates physiological function in response to the photoperiod.

8 Sep 2022

Phenotype News and Research

Study finds memory B cell clones harbor the capacity to adopt multiple and functionally different fates in COVID-19 patients

Age plays a more important role than genetics in affecting gene expression profiles as we get older

NEI researchers create a high-resolution map of retinal cell chromatin contract points

Study using human and animal-derived cell lines suggests human origin of SARS-CoV-2 Omicron variant

Acute kidney injury in hospitalized COVID-19 patients

Multiomic comparison shows a reduction in circulating monocytes correlated with persistent post-COVID-19 pulmonary fibrosis

Insights into the biology of virtual memory CD8+ T cells

Study suggests the immune system may benefit from a measure of stress

NIH launches new program to better understand the function of every human gene

Does leptin play a role in Parkinson’s disease?

Common germline variants of APOE contribute to differential COVID-19 outcomes

New mechanistic insights on the origin of SARS-CoV-2-induced neurological disorders

Research examines the roles of cytokines during SARS-CoV-2 infection in rhesus macaques

Research reveals pivotal role of C/EBPb in the development of alveolar macrophages

STRATAGEM aims to provide new perspectives on multidrug-resistant solid tumors

Walnut consumption early on in life may lead to better health as we age

The kinetics of T cell response, the inflammatory profile, and the pox-specific T cell induction in monkeypox infection

Mucosal vaccination triggers superior T cell response against SARS-CoV-2 variants

A direct side-by-side comparison of all available COVID-19 vaccines

How a key brain network responds to seasonal shifts in day length

Pioneering Live Cell Imaging - Yokogawa's Impact and Innovations

Revolutionizing Life Science: An Interview with SCIEX on ASMS, the SCIEX 7500+ System, and AI-Driven Quantitation

From Discovery Biology to ELRIG Chair

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