Protein News and Research

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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

Link between iron regulation and the immune system

Patients with chronic inflammatory disorders, including infections, inflammatory bowel disease, arthritis and cancer, commonly become anemic. The anemia can make them sicker, is sometimes severe enough to require a blood transfusion, and responds only partially to current treatments.

20 Apr 2004

Functional genomics provide improved drug discovery

Functional genomics and proteomics have been quite successful in identifying functions of potential therapeutic targets such as encoded proteins.

20 Apr 2004

Strict dieting can dramatically reduce the risk of heart disease

People who severely restrict their caloric intake drastically reduce their risk of developing diabetes or clogged arteries, the precursor to a heart attack or stroke. In fact, according to researchers at Washington University School of Medicine in St Louis, some risk factors were so low they were comparable to those of people decades younger.

19 Apr 2004

An experimental vaccine based on a critical piece of the SARS virus

An experimental vaccine based on a critical piece of the SARS virus protects mice from SARS infection, researchers from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, have found.

19 Apr 2004

Black women with high blood pressure during pregnancy have higher homocysteine levels

Black women with pregnancy-induced high blood pressure have more homocysteine (an amino acid linked with atherosclerosis) and less folic acid in their blood than white women.

19 Apr 2004

Proteomics helps fight colon cancer

Using new technology associated with the study of proteins, or proteomics, scientists at the National Cancer Institute (NCI), part of the National Institutes of Health (NIH), and their colleagues have made a step toward predicting which people with familial adenomatous polyposis.

19 Apr 2004

Curry offers possible protection against Alzheimer’s disease

A new study has found that curry, a common and popular cooking additive, could be an effective enhancer of an enzyme that protects the brain against oxidative conditions.

19 Apr 2004

Identification of first protein biomarkers to help patients with amyotrophic lateral sclerosis

A University of Pittsburgh pathologist has identified the first protein biomarkers able to diagnose patients with amyotrophic lateral sclerosis (ALS, also known as Lou Gehrig's disease) with near 100 percent accuracy. Before this finding, there were no known diagnostic biomarkers for this neurodegenerative disease.

18 Apr 2004

Using mass spectrometry to diagnose cancers and non-cancerous diseases

Using mass spectrometry, Emory University scientists have identified specific protein fingerprints in the cerebrospinal fluid (CSF) of humans that enable them to differentiate between cancers, both primary and metastatic, and non-cancerous diseases of the central nervous system (CNS).

18 Apr 2004

Researchers find drug that may suppress genetic mutation using a novel screening approach

Researchers at Massachusetts General Hospital have developed a way of identifying promising new drugs that may get around a major challenge in drug discovery.

18 Apr 2004

Newborn lambs’ central heating system could aid fat busting in humans

The way newborn lambs regulate their temperature in the first few weeks of life using a special deposit of brown fat could give clues for tackling obesity in humans, according to Imperial College London scientists.

18 Apr 2004

New diagnostic test for latent tuberculosis introduced

The Tuberculin skin test, used to detect latent Mycobacterium tuberculosis infection, has many drawbacks and a new diagnostic test for latent tuberculosis (QuantiFERON®-TB) has recently been introduced.

17 Apr 2004

Stem cell personal space determines their future

Johns Hopkins scientists report that restricting the shape and personal space of human stem cells from bone marrow is more important than any known molecular signal in determining the cell type they become.

16 Apr 2004

Possible new treatment strategy for Alzheimer's disease

A new study in mice identifies one of the missing steps in how Alzheimer's develops and suggests a possible new treatment strategy, according to researchers at Columbia University Medical Center and Weill Cornell Medical College and their colleagues.

16 Apr 2004

New gene presents a potent new target for breast cancer therapy

A gene known to promote longevity in animals has now been discovered to encode a tumor suppressor – a protein that helps prevent cancer, according to a study by a team of scientists from The University of Texas M. D. Anderson Cancer Center. The new gene, which was inactivated in two-thirds of patients studied, presents a potent new target for breast cancer therapy, the researchers say.

16 Apr 2004

New insights into how tumors neutralize CD8 T cells

Scientists have speculated that this may be because the immune response is not strong enough, or because it does not last long enough to have an effect. Hence the increasing efforts to develop cancer vaccines that induce, strengthen, and increase the duration of immunological attack against cancer cells.

16 Apr 2004

Cancer-specific protein offers new target for the development of melanoma vaccine

Scientists from the Cancer Vaccine Collaborative (CVC) have discovered that the cancer-specific protein, SSX-2, induces a spontaneous immunological reaction against cancer cells in melanoma patients, offering a new target for the development of a therapeutic melanoma vaccine. SSX-2 is the prototype of the SSX family, and is part of a larger group of proteins known as cancer/testis (CT) antigens.

16 Apr 2004

Three hours exercise reduces risk of breast cancer

Three hours of moderate exercise per week significantly reduced circulating estrogens in postmenopausal women, according to a new study published in the current issue of Cancer Research. The finding may explain why women who exercise regularly lower their risk for breast cancer.

16 Apr 2004

Proteomics techniques to find a possible predictor of response in a chemoprevention trial

16 Apr 2004

Scientists discover gene for Parkinson's disease

UCL scientists have discovered a new gene implicated in the early development of Parkinson's disease. In a study of families with early onset disease, Professor Nick Wood and colleagues at University College London's Institute of Neurology identified a novel gene which produces a malfunctioning protein that could pave the way for new treatments for Parkinson sufferers.

16 Apr 2004

Protein News and Research

Further Reading

Link between iron regulation and the immune system

Functional genomics provide improved drug discovery

Strict dieting can dramatically reduce the risk of heart disease

An experimental vaccine based on a critical piece of the SARS virus

Black women with high blood pressure during pregnancy have higher homocysteine levels

Proteomics helps fight colon cancer

Curry offers possible protection against Alzheimer’s disease

Identification of first protein biomarkers to help patients with amyotrophic lateral sclerosis

Using mass spectrometry to diagnose cancers and non-cancerous diseases

Researchers find drug that may suppress genetic mutation using a novel screening approach

Newborn lambs’ central heating system could aid fat busting in humans

New diagnostic test for latent tuberculosis introduced

Stem cell personal space determines their future

Possible new treatment strategy for Alzheimer's disease

New gene presents a potent new target for breast cancer therapy

New insights into how tumors neutralize CD8 T cells

Cancer-specific protein offers new target for the development of melanoma vaccine

Three hours exercise reduces risk of breast cancer

Proteomics techniques to find a possible predictor of response in a chemoprevention trial

Scientists discover gene for Parkinson's disease

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