Immune System News and Research

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COVID-19: HLA class I genotypes and mortality

The study, published on the preprint server medRxiv, explores the ability of HLA class I molecules to mediate the outcome in COVID-19 patients.

24 Nov 2020

First checkpoint inhibitor vaccine shown to be safe, effective in colon cancer animal model

A study led by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute described a potential therapeutic anticancer vaccine that frees suppressed cancer-killing immune cells, enabling them to attack and destroy a tumor.

23 Nov 2020

SARS-CoV-2's spike protein mutations have slowed, study finds

A team of researchers at the School of Information Sciences in Illinois, USA, has revealed the rate of mutation in the 29 proteins that make up the SARS-CoV-2 microbe.

23 Nov 2020

Oxford University and AstraZeneca release their COVID-19 vaccine results

AstraZeneca and the University of Oxford have just released their results from its interim analysis of AZD1222, a vaccine being trialed to prevent COVID-19.

From AstraZeneca 23 Nov 2020

FDA schedules meeting to discuss emergency use authorization of COVID-19 vaccine from Pfizer

Today, the U.S. Food and Drug Administration issued an emergency use authorization (EUA) for casirivimab and imdevimab to be administered together for the treatment of mild to moderate COVID-19 in adults and pediatric patients (12 years of age or older weighing at least 40 kilograms [about 88 pounds]) with positive results of direct SARS-CoV-2 viral testing and who are at high risk for progressing to severe COVID-19.

23 Nov 2020

Inflammatory factors that aggravate COVID-19 may come from adipose tissue

There is growing evidence that adipose tissue plays a key role in the aggravation of COVID-19. One of the theories under investigation is that fat cells (adipocytes) act as a reservoir for SARS-CoV-2 and increase viral load in obese or overweight individuals.

20 Nov 2020

Research reveals T-cell abnormalities in severe COVID-19 cases

There is an idea within the coronavirus research field that there is some kind of T cell abnormality in critically ill COVID-19 patients, but specific details have not yet been clarified.

20 Nov 2020

Furin inhibition may mitigate severe COVID-19, study finds

Dr. Kara Fitzgerald, a researcher at the Institute for Functional Medicine in the United States, has explained the role of furin protease in developing severe COVID-19 illness.

20 Nov 2020

Scientists explain potential reasons for SARS-CoV-2 re-infection

A study, which was published in the journal New Microbes and New Infections, focused on the possible reasons for SARS-CoV-2 reinfection.

20 Nov 2020

Scientists exploit 'trojan horse' feature in SARS-CoV-2 virus to create antivirals against COVID-19

Scientific analysis of a protein enzyme found in COVID-19 could lead to the development of new drugs to treat the virus, research led by Oxford Brookes University scientists has found.

20 Nov 2020

Lonza provides expansive selection of high-resolution HLA-typed primary cells to boost drug development

Lonza has announced that it now provides an expansive selection of high-resolution Human Leukocyte Antigen (HLA)-typed primary cells spanning all major cell and tissue types.

From Lonza 20 Nov 2020

Multi-institution team receives prestigious award for breakthrough research on SARS-CoV-2

The Association for Computing Machinery (ACM) awarded its first ACM Gordon Bell Special Prize for High Performance Computing-Based COVID-19 Research to a multi-institution research team that included the U.S. Department of Energy's (DOE) Argonne National Laboratory.

20 Nov 2020

Scientists develop a new vaccine approach for HIV

Unlike so many other deadly viruses, HIV still lacks a vaccine. The virus--which continues to infect millions around the world--has proven especially tricky to prevent with conventional antibodies, in part because it evolves so rapidly in the body.

20 Nov 2020

Antibody combinations may be more effective at preventing, treating COVID-19

Pairs of antibodies may be more effective than single antibodies at preventing and treating COVID-19, according to a new study by researchers at the University of North Carolina at Chapel Hill and The Rockefeller University in New York.

19 Nov 2020

Texas Biomed awarded $1 million to evaluate MAb therapeutics for COVID-19

Texas Biomedical Research Institute in San Antonio, Texas, was awarded $1 million from the Bill & Melinda Gates Foundation to test the efficacy of human monoclonal antibodies (MAbs) for the treatment of SARS-CoV-2 infection.

19 Nov 2020

Study shows link between COPD and the gut microbiome

Research led by the Centenary Institute, the University of Technology Sydney and the University of Queensland has shown for the first time a link between chronic obstructive pulmonary disease (COPD), an often fatal lung condition, and the gut microbiome.

19 Nov 2020

Immune mechanism responsible for adverse inflammatory reactions after stem cell transplant identified

In the treatment of leukemia, stem cell transplantation subsequent to chemotherapy and radiation can often engender severe adverse inflammatory reactions - especially in the skin or in the gut, since these so-called barrier organs are more frequently affected.

19 Nov 2020

Triple RNA sequencing dissects gene expression of virus and fungi in infection processes

Organ and stem cell transplants are proven and frequently used methods in everyday modern clinical practice. However, even when performed regularly in specialized centers, some patients still experience a number of serious complications afterward.

19 Nov 2020

Brain protein plays a major role in the development and growth of pancreatic cancer

Researchers have discovered that a protein thought to only be involved in the development of neurons in the brain also plays a major role in the development and growth of pancreatic cancer.

18 Nov 2020

Immunotherapies effective against lung cancer, melanoma may also work against rare skin tumor

Cutaneous angiosarcoma is a rare, highly aggressive skin tumor found primarily on the scalps of older White people, but based on new research from the University of North Carolina School of Medicine and the Lineberger Comprehensive Cancer Center, immunotherapies effective against lung cancer and melanoma may also work against this cancer.

18 Nov 2020

Immune System News and Research

COVID-19: HLA class I genotypes and mortality

First checkpoint inhibitor vaccine shown to be safe, effective in colon cancer animal model

SARS-CoV-2's spike protein mutations have slowed, study finds

Oxford University and AstraZeneca release their COVID-19 vaccine results

FDA schedules meeting to discuss emergency use authorization of COVID-19 vaccine from Pfizer

Inflammatory factors that aggravate COVID-19 may come from adipose tissue

Research reveals T-cell abnormalities in severe COVID-19 cases

Furin inhibition may mitigate severe COVID-19, study finds

Scientists explain potential reasons for SARS-CoV-2 re-infection

Scientists exploit 'trojan horse' feature in SARS-CoV-2 virus to create antivirals against COVID-19

Lonza provides expansive selection of high-resolution HLA-typed primary cells to boost drug development

Multi-institution team receives prestigious award for breakthrough research on SARS-CoV-2

Scientists develop a new vaccine approach for HIV

Antibody combinations may be more effective at preventing, treating COVID-19

Texas Biomed awarded $1 million to evaluate MAb therapeutics for COVID-19

Study shows link between COPD and the gut microbiome

Immune mechanism responsible for adverse inflammatory reactions after stem cell transplant identified

Triple RNA sequencing dissects gene expression of virus and fungi in infection processes

Brain protein plays a major role in the development and growth of pancreatic cancer

Immunotherapies effective against lung cancer, melanoma may also work against rare skin tumor

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