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Northwestern Medicine scientists discover new gene target for aggressive lung cancer

Northwestern Medicine scientists have identified and described a new gene that is responsible for activating an aggressive subtype of small-cell lung cancer, the P subtype, for which there is no current effective treatment.

5 Oct 2022

Mount Sinai study suggests significant role of reactive oxygen species in maintaining healthy intestines

Mount Sinai researchers have published one of the first studies to demonstrate the importance of reactive oxygen species in maintaining stem cell function and preventing inflammation during wound repair, which could provide greater insights into the prevention and treatment of inflammatory bowel diseases (IBD), according to findings published in the journal Gut on October 3.

3 Oct 2022

New capsule tunnels through mucus in the GI tract to deliver large protein drugs

One reason that it's so difficult to deliver large protein drugs orally is that these drugs can't pass through the mucus barrier that lines the digestive tract.

28 Sep 2022

Study suggests the immune system may benefit from a measure of stress

Stress has been linked to all sorts of serious health issues, from insomnia to high blood pressure, obesity and even heart disease. But it's generally acknowledged that some stress can also be helpful, like when someone's chasing a work deadline.

28 Sep 2022

Can the gut be an alternative route for SARS-CoV-2 entry?

Researchers reviewed the gut pathophysiology of SARS-CoV-2 infection.

28 Sep 2022

Bile acids play an important role in regulating gut microbiome

Scientists performe in vitro and in vivo experiments to investigate the antimicrobial effects of different bile acids on various microorganisms.

27 Sep 2022

How the gut microbiome could affect COVID-19 severity

Researchers review the potential role of the gut microbiome in determining severe COVID-19.

27 Sep 2022

Spectroscopy reveals a high abundance of microplastics in human placenta

Scientists have used a spectroscopy technique to identify and characterize microplastics in the human placenta. The study published in the journal Science of The Total Environment provides a detailed overview of the size, shape, and nature of microplastics found in the placenta.

27 Sep 2022

Using AI during colonoscopy increases polyp detection rates, reduces costs

A polyp is a small growth of tissue in the colon that can evolve into colorectal cancer. Patients with polyps have a higher risk of evolving cancer in the future.

27 Sep 2022

The potential of NMR-based blood profiling as a single-domain assay to simultaneously predict multidisease onset

Researchers explored the potential of a nuclear magnetic resonance spectroscopy-based metabolomic platform to estimate the risks for the onset of several medical conditions.

27 Sep 2022

New machine learning tool discovers mutational signature that links bladder cancer to tobacco smoking

Researchers at the University of California San Diego have for the first time discovered a pattern of DNA mutations that links bladder cancer to tobacco smoking.

27 Sep 2022

In vitro gut models reveal how microplastics affect the GI tract

Researchers hypothesize that exposure to polyethylene microplastics affect the human adult GI system in vitro under realistic conditions.

26 Sep 2022

Tumors generate unique, temporary cell-in-cell structures to evade immunotherapy

Scientists have shown how tumour cells evade immunotherapy by generating unique, temporary cell-in-cell structures, where the inner cells remain in tact and can return to single tumour cells.

20 Sep 2022

Is aspirin linked to higher rates of survival for cancer patients?

Researchers discussed the existing evidence on the use of acetylsalicylic acid (aspirin) in cancer treatment.

19 Sep 2022

Soy protein diet increases susceptibility to Clostridioides difficile infection

According to a recent study published in the journal Cell Reports, a diet rich in soy protein increases human Clostridioides difficile susceptibility by increasing the gut amino acids (AAs) levels and promoting the growth of Lactobacillus.

18 Sep 2022

Research examines the roles of cytokines during SARS-CoV-2 infection in rhesus macaques

In a recent study posted to the bioRxiv* preprint server, researchers in the United States assessed the role of two cytokines, interferon-gamma (IFN-γ) and interleukin-10 (IL-10), in regulating immune cell responses and inflammation early during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in rhesus macaques.

18 Sep 2022

Study explores the impact of genetic risk variants on overall disease burden and healthy life years

In a new study, researchers explored the genetic risk factors associated with various diseases to understand their impact on healthy life years.

14 Sep 2022

Study investigates the efficacy and safety of selpercatinib in a diverse group of patients

The highly selective RET inhibitor selpercatinib was well-tolerated and achieved durable objective responses across multiple tumor types in the Phase I/II LIBRETTO-001 trial, according to researchers from The University of Texas MD Anderson Cancer Center.

13 Sep 2022

Phase I/II LIBRETTO-001 trial: RET inhibitor achieves durable objective responses across multiple tumors

12 Sep 2022

Using Q-bodies for imaging intracellular proteins in live cells

Recent advances in imaging technology have made it possible to visualize intracellular dynamics, which offers a better understanding of several key biological principles for accelerating therapeutic development.

9 Sep 2022

Colon News and Research

Northwestern Medicine scientists discover new gene target for aggressive lung cancer

Mount Sinai study suggests significant role of reactive oxygen species in maintaining healthy intestines

New capsule tunnels through mucus in the GI tract to deliver large protein drugs

Study suggests the immune system may benefit from a measure of stress

Can the gut be an alternative route for SARS-CoV-2 entry?

Bile acids play an important role in regulating gut microbiome

How the gut microbiome could affect COVID-19 severity

Spectroscopy reveals a high abundance of microplastics in human placenta

Using AI during colonoscopy increases polyp detection rates, reduces costs

The potential of NMR-based blood profiling as a single-domain assay to simultaneously predict multidisease onset

New machine learning tool discovers mutational signature that links bladder cancer to tobacco smoking

In vitro gut models reveal how microplastics affect the GI tract

Tumors generate unique, temporary cell-in-cell structures to evade immunotherapy

Is aspirin linked to higher rates of survival for cancer patients?

Soy protein diet increases susceptibility to Clostridioides difficile infection

Research examines the roles of cytokines during SARS-CoV-2 infection in rhesus macaques

Study explores the impact of genetic risk variants on overall disease burden and healthy life years

Study investigates the efficacy and safety of selpercatinib in a diverse group of patients

Phase I/II LIBRETTO-001 trial: RET inhibitor achieves durable objective responses across multiple tumors

Using Q-bodies for imaging intracellular proteins in live cells

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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