Immune System News and Research

RSS

Proteolytic cleavage of nucleocapsid helps SARS-CoV-2 evade host immune responses

A team of scientists of the University of Oxford reveals that the nucleocapsid protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) undergoes autoproteolysis, and that resulting products can escape the host immune responses and facilitate viral proliferation. The study is currently available on the bioRxiv preprint server.

7 Oct 2020

Multi-center Phase I study of anti-VISTA opens for patient enrollment

Dartmouth and Dartmouth-Hitchcock Norris Cotton Cancer Center will serve as one of the lead institutions for a new multi-center clinical trial of anti-VISTA, now open and recruiting for patient enrollment.

7 Oct 2020

TCR's quantity and clonality are linked to prognosis of colorectal cancer

Colorectal cancer (CRC) is the third most common cancer in the world, with more than one and a half million new cases diagnosed annually.

7 Oct 2020

Study shows how CD4+ T cells respond to SARS-CoV-2 virus

As scientists around the world develop life-saving COVID-19 vaccines and therapies, many are still wondering exactly why the disease proves deadly in some people and mild in others.

7 Oct 2020

A global review of COVID-19 impact on cancer treatment and research

The COVID-19 pandemic has impacted virtually every aspect of cancer care and research- from introducing new risks for cancer patients to disrupting the delivery of cancer treatment and the continuity of cancer research, a review of scientific literature shows.

7 Oct 2020

ACGT awards $500,000 grant to advance strategies for treating solid tumors

With a $500,000 Research Grant from Alliance for Cancer Gene Therapy, Sidi Chen, PhD, assistant professor in the Department of Genetics and Systems Biology Institute at Yale School of Medicine and member of Yale Cancer Center, will advance a versatile and highly scalable strategy he's been developing and calling MAEGI -- Multiplexed Activation of Endogenous Genes as an Immunotherapy.

6 Oct 2020

Study shows how mysterious molecular concept could be used to target diseased cells

A growing area of medicine looks at how cellular binding observed in nature - where molecules like viruses or proteins bind to specific receptors on a cell - can be mimicked to aid drug delivery.

6 Oct 2020

Cancer mutations are found in distinct regions that vary based on genomic structure and mutation

A new study from researchers at The University of Texas MD Anderson Cancer Center has discovered that mutations found in cancers do not accumulate randomly, but are found in distinct patterns that vary based on the three-dimensional organization of the genome in the cell as well as the underlying factors causing the mutations

6 Oct 2020

IL-21 protein is a major part of immune response to chronic infections in the central nervous system

Researchers at Penn State College of Medicine now better understand the role of a protein, interleukin-21 (IL-21), in the immune system response to infections in the nervous system.

6 Oct 2020

Study shows why antiretroviral therapy does not work in certain HIV patients

Increasingly, UPMC's chief of infectious diseases-;a well-regarded expert in HIV/AIDS-;is contacted by a perplexed physician describing a patient with HIV who insists they are adhering to the daily medication regimen meant to keep the virus in check, but testing says otherwise.

6 Oct 2020

New findings could improve investigation of T cell response to COVID-19

Researchers in the United States have made an important discovery about the processing and presentation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral peptides that provides a better understanding of the immune response to coronavirus disease 2019 (COVID-19) and may help facilitate the design of improved vaccines.

5 Oct 2020

Two phase II clinical trials suggest potential new treatment options for metastatic cervical cancer

Preliminary results from two independent, phase II clinical trials investigating a new PD-1 (programmed cell death protein 1)-based immune therapy for metastatic cervical cancer suggest potential new treatment options for a disease that currently has limited effective options and disproportionately impacts younger women.

5 Oct 2020

Advanced model reveals dynamic motions of SARS-COV-2 spike-shielding glycans

A recent paper published on the preprint server bioRxiv in September 2020 discusses the dynamic interactions of the spike protein glycan shield, which may be of great value in developing therapeutic compounds to fight severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

5 Oct 2020

Ludwig study uncovers a nutritional approach to improve cancer immunotherapy

A Ludwig Cancer Research study has uncovered a mechanism by which the tumor's harsh internal environment sabotages T lymphocytes, leading cellular agents of the anticancer immune response.

5 Oct 2020

Researchers receive $3.2 million to use AI for improving heart transplant outcomes

A team of researchers in the Perelman School of Medicine at the University of Pennsylvania, Case Western Reserve University, Cleveland Clinic, and Cedars-Sinai Medical Center, were recently awarded a $3.2 million grant from the National Institutes of Health to enhance research for improving heart transplant outcomes for patients.

5 Oct 2020

Applying the power of AI to improve heart-transplant outcomes

The team of biomedical researchers at the Center for Computational Imaging and Personalized Diagnostics has tackled various aspects of lung cancer, breast cancer, colon cancer and more since the center was launched at Case Western Reserve University in 2012 by bioengineering pioneer Anant Madabhushi.

5 Oct 2020

Supporting Coronavirus Research with Liquid Chromatography

The RNA in viruses such as SARS-CoV-2 are an ideal research target. RNA purification with liquid chromatography is essential in the fight against SARS-CoV-2.

From KNAUER Wissenschaftliche Geräte GmbH 5 Oct 2020

Another study finds cross-reactivity T cell responses against SARS-CoV-2

Using ELISpot and proliferation assays, researchers show strong responses in SARS-CoV-2 infected patients, but not so much in negative samples. However, there may be cross-reactive T cell responses from other human coronaviruses.

5 Oct 2020

Investigation of SARS-CoV-2 antibody responses in patients with aggressive hematological malignancies

Patients with hematological malignancy (PHM), also infected with COVID-19, were investigated for SARS-CoV-2 antibody responses while undergoing systemic anti-cancer therapy. While no obvious correlation is found between the serological results and the hematological diagnosis and the treatment, the immune response is similar to the severity of COVID-19 infection observed in the general population.

4 Oct 2020

Study reveals how immune cells sacrifice themselves to help fight off infections

Whether flu or coronavirus, it can take several days for the body to ramp up an effective response to a viral infection.

1 Oct 2020

Immune System News and Research

Proteolytic cleavage of nucleocapsid helps SARS-CoV-2 evade host immune responses

Multi-center Phase I study of anti-VISTA opens for patient enrollment

TCR's quantity and clonality are linked to prognosis of colorectal cancer

Study shows how CD4+ T cells respond to SARS-CoV-2 virus

A global review of COVID-19 impact on cancer treatment and research

ACGT awards $500,000 grant to advance strategies for treating solid tumors

Study shows how mysterious molecular concept could be used to target diseased cells

Cancer mutations are found in distinct regions that vary based on genomic structure and mutation

IL-21 protein is a major part of immune response to chronic infections in the central nervous system

Study shows why antiretroviral therapy does not work in certain HIV patients

New findings could improve investigation of T cell response to COVID-19

Two phase II clinical trials suggest potential new treatment options for metastatic cervical cancer

Advanced model reveals dynamic motions of SARS-COV-2 spike-shielding glycans

Ludwig study uncovers a nutritional approach to improve cancer immunotherapy

Researchers receive $3.2 million to use AI for improving heart transplant outcomes

Applying the power of AI to improve heart-transplant outcomes

Supporting Coronavirus Research with Liquid Chromatography

Another study finds cross-reactivity T cell responses against SARS-CoV-2

Investigation of SARS-CoV-2 antibody responses in patients with aggressive hematological malignancies

Study reveals how immune cells sacrifice themselves to help fight off infections

Immunology eBook

Decoding Cannabis: Differentiating Hemp and Marijuana

Deciphering the Microbiome with The Microsetta Initiative

Leveraging the power of automation to boost research

Latest News