Phenotype News and Research

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Case report: human breast milk from vaccinated woman clears persistent SARS-CoV-2 infection

A new study published in the journal Viruses aimed to report the effects of plasma infusion and then breastmilk ingestion as a therapy for persistent SARS-CoV-2 infection in a patient with a common variable immunodeficiency (CVID) phenotype.

18 May 2022

PerkinElmer expands genomic testing services with ultrarapid whole genome sequencing

PerkinElmer, Inc., a global leader committed to innovating for a healthier world, today announced the availability of ultrarapid whole genome sequencing (urWGS) through PerkinElmer Genomics.

From Revvity 17 May 2022

Evolution of SARS-CoV-2 variants of concern

Researchers investigated the evolution of different SARS-CoV-2 variants of concern.

16 May 2022

Exploring age-associated differences in T lymphocyte immune responses after BNT162b2 vaccination

Researchers compared the immunogenicity of or and reactogenicity to the BNT162b2 vaccine in Japanese adults and elders.

16 May 2022

Chronic obstructive pulmonary disease leads to premature senescence of the immune system

A study conducted at the University of São Paulo's Medical School (FM-USP) in Brazil, with results reported in an article published in the journal Immunity & Ageing, shows that chronic obstructive pulmonary disease (COPD) leads to premature senescence (age-related impairment) of the immune system.

13 May 2022

A*STAR, NHCS, NUS, and Novo Nordisk partner to study the mechanisms underlying heart failure

The Agency for Science, Technology and Research's Genome Institute of Singapore and Bioinformatics Institute, as well as the National Heart Centre Singapore, National University of Singapore, and pharmaceutical company Novo Nordisk have signed an agreement to study the mechanisms underlying cardiovascular disease progression-; especially the condition called heart failure with preserved ejection fraction (HFpEF).

13 May 2022

SARS-CoV-2 N-terminal domain modulates S1/S2 cleavage and spike-mediated functions

In a recent study posted to the bioRxiv* preprint server, researchers explored the role of the N-terminal domain (NTD) of the severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) spike (S) protein in SARS-CoV-2 fusion with the host membranes and coronavirus disease 2019 (COVID-19).

12 May 2022

Investigating the role of cyclins and cyclin-dependent kinases in host restriction of SARS-CoV-2 infection

Researchers investigated COVID-19-triggered changes in the levels of cyclins and cyclin-dependent kinases inside host cells.

10 May 2022

A hybrid, multiscale, individual-based model to study the within-host spread of SARS-CoV-2 and the subsequent innate immune response

In this study, the authors have specifically studied the interactions of epithelial cells, a subset of cytokines and macrophages.

10 May 2022

More evidence that pediatric COVID vaccination prevents MIS-C

Researchers designed a nationwide pediatric COVID-19 research project based on real-time data since the early phase of the pandemic.

9 May 2022

Study evaluates the associations between predisposing risk factors and heart attack in young women

A new Yale-led study has for the first time identified which risk factors are more likely to trigger a heart attack or acute myocardial infarction (AMI) for men and women 55 years and younger.

4 May 2022

Researchers develop novel technique to identify relationships among medical concepts

A team of researchers from the Department of Veterans Affairs, Oak Ridge National Laboratory, Harvard's T.H. Chan School of Public Health, Harvard Medical School and Brigham and Women's Hospital has developed a novel, machine learning–based technique to explore and identify relationships among medical concepts using electronic health record data across multiple healthcare providers.

28 Apr 2022

DGP student investigates sexual dysmorphism in mice

Isabella Salamone is an eighth-year student in the Driskill Graduate Program in Life Sciences (DGP) who is studying sexual dysmorphism in mice in the laboratory of Elizabeth McNally, MD, PhD, the Elizabeth J. Ward Professor of Genetic Medicine and director of the Center for Genetic Medicine.

28 Apr 2022

Researchers use a systems biology approach to parse the genetic diversity of C. difficile

Researchers at University of California San Diego School of Medicine and Jacobs School of Engineering, with colleagues at Baylor College of Medicine, have used a systems biology approach to parse the genetic diversity of Clostridioides difficile, a particularly problematic pathogen in health care settings.

27 Apr 2022

The preclinical potential of a herb used in traditional Chinese medicine for the treatment of COVID-19

In a study published in Cells, researchers have been investigating the effects of this extract for use against COVID-19.

27 Apr 2022

Researchers reveal how not-yet-malignant cells “turn on” and become metastatic breast cancer

Mount Sinai researchers have discovered a previously unknown mechanism in which not-yet-malignant cells from early breast cancer tumors travel to other organs and, eventually, "turn on" and become metastatic breast cancer.

26 Apr 2022

Researchers use mouse model to explore correlation of impaired interferon-mediated immune response with severe COVID-19

Researchers developed a highly pathogenic mouse-adapted SARS-CoV-2 strain to model mild, moderate, or COVID-19.

26 Apr 2022

Clinical traits with inflammation characterization of long COVID and correlation with one-year recovery after COVID-19-linked hospitalization

Researchers presented the clinical traits with inflammation characterization of long COVID and correlation with one-year recovery after COVID-19-linked hospitalization.

26 Apr 2022

Exploring Populations of B and T Cells in Lymph Nodes of Patients Diagnosed with COVID-19 via Microscopy and Image Analysis

My work is focused on looking at the dynamics of B/T cell populations within lymph nodes from patients that had recovered from COVID-19. My role in this research was developing and implementing microscopy image analysis techniques using methods and instrumentation in part supplied by TissueGnostics.

From TissueGnostics 26 Apr 2022

Understanding the Choice Between Individual Versus Social Housing Mice and Its Impact On Research

In this interview, Steffen van Heijningen discusses the differences between individual and social housing of mice and how housing conditions can impact the research.

From Noldus Information Technology 26 Apr 2022

Phenotype News and Research

Case report: human breast milk from vaccinated woman clears persistent SARS-CoV-2 infection

PerkinElmer expands genomic testing services with ultrarapid whole genome sequencing

Evolution of SARS-CoV-2 variants of concern

Exploring age-associated differences in T lymphocyte immune responses after BNT162b2 vaccination

Chronic obstructive pulmonary disease leads to premature senescence of the immune system

A*STAR, NHCS, NUS, and Novo Nordisk partner to study the mechanisms underlying heart failure

SARS-CoV-2 N-terminal domain modulates S1/S2 cleavage and spike-mediated functions

Investigating the role of cyclins and cyclin-dependent kinases in host restriction of SARS-CoV-2 infection

A hybrid, multiscale, individual-based model to study the within-host spread of SARS-CoV-2 and the subsequent innate immune response

More evidence that pediatric COVID vaccination prevents MIS-C

Study evaluates the associations between predisposing risk factors and heart attack in young women

Researchers develop novel technique to identify relationships among medical concepts

DGP student investigates sexual dysmorphism in mice

Researchers use a systems biology approach to parse the genetic diversity of C. difficile

The preclinical potential of a herb used in traditional Chinese medicine for the treatment of COVID-19

Researchers reveal how not-yet-malignant cells “turn on” and become metastatic breast cancer

Researchers use mouse model to explore correlation of impaired interferon-mediated immune response with severe COVID-19

Clinical traits with inflammation characterization of long COVID and correlation with one-year recovery after COVID-19-linked hospitalization

Exploring Populations of B and T Cells in Lymph Nodes of Patients Diagnosed with COVID-19 via Microscopy and Image Analysis

Understanding the Choice Between Individual Versus Social Housing Mice and Its Impact On Research

Pioneering Live Cell Imaging - Yokogawa's Impact and Innovations

Revolutionizing Life Science: An Interview with SCIEX on ASMS, the SCIEX 7500+ System, and AI-Driven Quantitation

From Discovery Biology to ELRIG Chair

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