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Scientists extend the lifespan of mice

Scientists at the University of Washington and their colleagues at other research centers have found a way to significantly extend the lifespan of mice while reducing the impact of the aging process. Their study, which will be published online by the journal Science on May 5, lends more credence to the free-radical theory of aging.

5 May 2005

Does clinical depression bring about chronic pain? Or does pain lead to depression?

Does clinical depression bring about chronic pain? Or does pain lead to depression? Because these two conditions frequently co-exist--30 to 54 percent of patients with major depressive disorder also suffer persistent physical pain--there has been much speculation about whether one causes the other or whether a common underlying factor provokes both. Results of studies into the precise nature of this relationship, however, have been inconsistent.

5 May 2005

New cervical cancer drug could be a bestseller

New data released yesterday says that a new vaccine that promises to protect against cervical cancer could offer wider resistance to the disease than previously thought.

5 May 2005

RADAR may have already saved hundreds of thousands of lives

As many as hundreds of thousands of lives may have saved by a program that identifies serious, sometimes fatal medication reactions.

4 May 2005

New GP contract may not improve treatment for heart failure patients

The new contract for GPs may improve identification and diagnosis of chronic heart failure, but there is a danger that it may fall short of ensuring optimal treatment for these patients, says research published this week in Postgraduate Medical Journal.

4 May 2005

The humble snail is helping scientists explore ways of treating memory loss in humans

Drug manufacturers are looking at ways to create a "Viagra for the brain", which could alleviate memory loss, one of the distressing symptoms of diseases such as Alzheimer's. Work carried out by Dr George Kemenes, Senior Fellow in the Department of Biology and Environmental Science at the University of Sussex, will hopefully help to show how such drugs could work.

4 May 2005

War on AIDS needs food

The five billion dollars earmarked by U.S. President George W. Bush to fight HIV/AIDS could be wasted if his administration does not increase food aid resources, asserted the head of a leading development organization.

4 May 2005

Specific variants of genes predict bleeding after heart surgery

Duke University Medical Center researchers have found that the presence of specific variants of genes that control clotting and the contractility, or "tone," of blood vessels can double the ability of physicians to predict those heart surgery patients at greatest risk of bleeding after surgery.

4 May 2005

Researchers unravel how nature releases the torque built up in DNA at the molecular level

A Dutch led international team of researchers has unravelled how nature releases the torque built up in DNA at the molecular level. The researchers from Delft University of Technology, the Ecole Normale Supérieure in Paris and the Sloan-Kettering Institute in New York published their findings in the 31 March 2005 issue of Nature. An artistic impression of the enzyme at work is featured on the cover of this issue.

4 May 2005

Newly identified fly genes provide clue to tumour growth

Researchers from the Oxford University Department of Human Anatomy and Genetics have found a new class of genes that are critical for cell growth and may be involved in the uncontrolled growth that takes place in cancer. The discovery could provide a key to future tumour therapies.

4 May 2005

Vaccine developed at Rockefeller University boosts natural killer T cells in patients with cancer

A new vaccine designed at The Rockefeller University boosted a type of fast-responding immune system cell called the natural killer T (NKT) cell in patients with advanced cancer. The study surprised researchers by revealing the ability of these NKT cells to spur other, slower-responding immune cells to go to work.

4 May 2005

Heart failure patients do better when treated according to guidelines, but too many doctors still fail to prescribe the best treatments

Heart failure patients who are treated in accordance with established European guidelines do better than patients who are not, yet many doctors are still not adhering to the guidelines, according to pioneering research published in Europe’s leading cardiology journal, the European Heart Journal.

4 May 2005

Abnormal heart scans predict higher risks for African-Americans and Hispanics

SPECT imaging scans show that abnormalities in blood flow to the muscle of the heart indicate higher cardiovascular disease risk in African-Americans and Hispanics than similar abnormalities in white patients, according to a new study (PDF) in the May 3, 2005, issue of the Journal of the American College of Cardiology.

4 May 2005

45% of US drug arrests are for marijuana, is this a waste of resources?

A great deal of time and money as well as man-power is spent on chasing after people using, possessing and trafficking in drugs. Since 1990, there have been 6.2 million arrests for marijuana possession and 1 million for marijuana trafficking.

3 May 2005

Study identifies possible marker for efficacy of gefitinib in lung cancer patients

Patients with advanced non–small-cell lung cancer (NSCLC) whose tumor cells contain extra copies of the epidermal growth factor receptor (EGFR) gene may be more likely to respond to the drug gefitinib (Iressa), and this high gene copy number may be an effective predictor of gefitinib efficacy, according to a new study in the May 4 issue of the Journal of the National Cancer Institute.

3 May 2005

Monitoring program has successfully identified a large number of previously unknown, serious and often-fatal drug reactions

A monitoring program developed by a Northwestern University researcher has successfully identified a large number of previously unknown, serious and often-fatal drug reactions associated with 15 commonly used drugs, including Plavix®, thalidomide and drug-coated cardiac stents.

3 May 2005

Critical lock and key mechanism found for the assembly of tumor blood vessels

A critical lock and key mechanism that allows the final step in the completion of new blood vessel formation has been identified by a University of California, San Diego (UCSD) School of Medicine team in research that promises to lead to a new way to halt tumor growth by cutting off the tumor blood supply.

3 May 2005

When it comes to low fat diets - all are not equal!

New research from the Stanford University School of Medicine re-enforces what Mum always told you, eat those veggies and those other nutrient-dense foods because they're good for you!

2 May 2005

Alarms better than medication for stopping bedwetting

Alarms that buzz, ring or light up when a child wets the bed are more effective at stopping bedwetting than medications like the drug commonly used to prevent urination, according to a new review of recent studies.

2 May 2005

Promising results from study of Pirfenidone in idiopathic pulmonary fibrosis (IPF) patients

InterMune today announced that the American Journal of Respiratory and Critical Care Medicine (AJRCCM) published results from a double-blind, randomized, placebo-controlled Phase II trial evaluating pirfenidone for the treatment of patients with idiopathic pulmonary fibrosis (IPF).

2 May 2005

Drugs News and Research

Scientists extend the lifespan of mice

Does clinical depression bring about chronic pain? Or does pain lead to depression?

New cervical cancer drug could be a bestseller

RADAR may have already saved hundreds of thousands of lives

New GP contract may not improve treatment for heart failure patients

The humble snail is helping scientists explore ways of treating memory loss in humans

War on AIDS needs food

Specific variants of genes predict bleeding after heart surgery

Researchers unravel how nature releases the torque built up in DNA at the molecular level

Newly identified fly genes provide clue to tumour growth

Vaccine developed at Rockefeller University boosts natural killer T cells in patients with cancer

Heart failure patients do better when treated according to guidelines, but too many doctors still fail to prescribe the best treatments

Abnormal heart scans predict higher risks for African-Americans and Hispanics

45% of US drug arrests are for marijuana, is this a waste of resources?

Study identifies possible marker for efficacy of gefitinib in lung cancer patients

Monitoring program has successfully identified a large number of previously unknown, serious and often-fatal drug reactions

Critical lock and key mechanism found for the assembly of tumor blood vessels

When it comes to low fat diets - all are not equal!

Alarms better than medication for stopping bedwetting

Promising results from study of Pirfenidone in idiopathic pulmonary fibrosis (IPF) patients

Drug Discovery - Second Edition eBook

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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