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Studying monkeys social judgments could provide clues to autism

Researches have found that monkeys will "pay" juice rewards to see images of high-ranking monkeys or female hindquarters. They say their research technique offers a rigorous laboratory approach to studying the "social machinery" of the brain and how this machinery goes tragically awry in autism -- a disease that afflicts more than a million Americans and is the fastest growing developmental disorder.

30 Jan 2005

Scientists have coaxed human embryonic stem cells to become spinal motor neurons

After years of trial and error, scientists have coaxed human embryonic stem cells to become spinal motor neurons, critical nervous system pathways that relay messages from the brain to the rest of the body.

30 Jan 2005

Startling results from new biomedical research will smooth path to the market place

Researchers have discovered how to convert liver cells of mice into pancreatic cells using a single injection. This may eventually lead to a cure for diabetes. Dr. James Mittra, one of the organisers of an international conference in Edinburgh on the Evolution of the Life Science Industries asks, “How does the pharmaceutical industry respond to this kind of work? They are primarily interested in treatments, not cures. Do they see this kind of research as a threat?”

27 Jan 2005

Paracetamol effective for chronic pain and arthritis

A research team from University of Queensland has just published the results of a small study into the effectiveness of medications for chronic pain.

27 Jan 2005

Study focuses on best treatment for older women with receptor negative early breast cancer

Older women with hormone receptor negative early breast cancer who may currently be missing out on effective post-operative anticancer drugs will be able to participate in a new clinical trial specifically aimed at this group of women.

27 Jan 2005

Clinical trials to test the safety of a first-of-its-kind human hookworm vaccine

Clinical trials to test the safety of a first-of-its-kind human hookworm vaccine will begin in the Washington, DC area in a couple of months after the U.S. Food and Drug Administration conferred investigational new drug status on the vaccine.

27 Jan 2005

Doctors under pressure to compromise good health care for athletes

Doctors are repeatedly coming under pressure to compromise principles of good health care when treating athletes, reveals a small preliminary study in the Journal of Medical Ethics.

26 Jan 2005

Trial of Etanercept for Wegners's disease shows no benefit against the autoimmune condition

A Johns Hopkins-led study designed to evaluate the ability of etanercept to maintain disease remissions in a serious autoimmune disorder has failed to show any benefit. Etanercept, also called Enbrel, is a common treatment for rheumatoid arthritis and other types of joint inflammation.

26 Jan 2005

Painful surgical adhesions may be preventable by taking the COX-2 inhibitor Celebrex

Adhesions – bands of scar tissue that bind together two internal body surfaces – develop in 55 percent to more than 90 percent of patients undergoing surgery, depending on the type of operation. They are part of normal healing, but when surfaces fuse together that shouldn't, serious pain and complications can result.

26 Jan 2005

$Phenoxodiol gets fast track status for its intended use in patients with hormone-refractory prostate cancer$

Phenoxodiol gets fast track status for its intended use in patients with hormone-refractory prostate cancer

Marshall Edwards today announced that the U.S. Food and Drug Administration (FDA) has granted the investigational anti-cancer drug, phenoxodiol, fast track status for its intended use in patients with hormone- refractory prostate cancer (HRPC).

26 Jan 2005

WHO announces $2 billion gap in financing for AIDS treatment

Today, at the Davos World Economic Forum in Switzerland, the World Health Organization (WHO) released a report showing a "rapid expansion" in the number of people living in poor countries gaining access to life-saving AIDS treatment.

26 Jan 2005

Tentative approval of co-packaged lamivudine/zidovudine fixed dose combination tablets and nevirapine tablets

The Food and Drug Administration (FDA) has announced the tentative approval of a co-packaged antiretroviral drug regimen manufactured by Aspen Pharmacare of South Africa for the treatment of HIV-1 infection in adults.

26 Jan 2005

Why some men develop aggressive prostate cancer that becomes resistant to hormone-withdrawal therapy

Researchers found that certain mutations in a protein called the androgen receptor cause advanced and invasive prostate cancer when put into otherwise healthy mice. The androgen receptor's normal function is to control growth of the prostate gland in response to cues from male hormones called androgens, which have long been thought to stimulate prostate tumors.

26 Jan 2005

Genetic defect leads to electrical instability and mechanical pump failure

In genetic mapping of a large family with several members affected by a type of heart failure called dilated cardiomyopathy (DCM), the Mayo Clinic team found a defect in a gene on chromosome 3 called SCN5A.

26 Jan 2005

New highly active agents against leishmaniasis

Parasitic diseases, especially leishmaniases and trypanosomiases, kill hundreds of thousands of people every year in the world, mainly in the countries of the South. The most severe form of leishmaniosis (kala-azar, the visceral form), induced by Leishmania donovani and L. infantum, affects about 500 000 people per year and proves fatal if no treatment is given.

25 Jan 2005

Monoclonal antibody therapeutics to fill vacuum left by ineffective conventional therapies

Currently, the limited efficacy of conventional therapies, especially in the case of several oncology and autoimmune and inflammatory disorders (AIID), is creating the need for safe and effective treatment alternatives.

25 Jan 2005

Plant protein mimics hormone that mitigates diabetes and obesity

A common protein that protects plants from fungal infection mimics the activity of a hormone in mammals that is linked to weight loss and is believed to play a role in mitigating heart disease, obesity and diabetes, according to a team of researchers at Purdue University and several collaborating institutions.

25 Jan 2005

Vioxx could have caused 140000 excess cases of coronary heart disease in the USA since 1999

The arthritis drug Vioxx could have caused an estimated 88 000–140 000 excess cases of serious coronary heart disease in the USA since its launch in 1999, concludes a study published online by The Lancet.

24 Jan 2005

Vioxx withdrawal raises many questions concerning drug policy

Daniel H. Solomon, M.D., M.P.H., from Brigham and Women’s Hospital, Boston, and Jerry Avorn, M.D., of Harvard University School of Medicine, write in the January 24 issue of Archives of Internal Medicine that the withdrawal of rofecoxib (Vioxx) from the market in September 2004 by its manufacturer, Merck & Co., “raises many questions concerning drug policy, scientific evidence, and treatment alternatives.

24 Jan 2005

More studies on risks and benefits of COX-2 inhibitors

A group of studies published in the January 24 issue of Archives of Internal Medicine add to the growing body of medical literature about the cardiovascular risks that may be associated with the class of pain-relieving drugs known as COX-2 inhibitors.

24 Jan 2005

Drugs News and Research

Studying monkeys social judgments could provide clues to autism

Scientists have coaxed human embryonic stem cells to become spinal motor neurons

Startling results from new biomedical research will smooth path to the market place

Paracetamol effective for chronic pain and arthritis

Study focuses on best treatment for older women with receptor negative early breast cancer

Clinical trials to test the safety of a first-of-its-kind human hookworm vaccine

Doctors under pressure to compromise good health care for athletes

Trial of Etanercept for Wegners's disease shows no benefit against the autoimmune condition

Painful surgical adhesions may be preventable by taking the COX-2 inhibitor Celebrex

Phenoxodiol gets fast track status for its intended use in patients with hormone-refractory prostate cancer

WHO announces $2 billion gap in financing for AIDS treatment

Tentative approval of co-packaged lamivudine/zidovudine fixed dose combination tablets and nevirapine tablets

Why some men develop aggressive prostate cancer that becomes resistant to hormone-withdrawal therapy

Genetic defect leads to electrical instability and mechanical pump failure

New highly active agents against leishmaniasis

Monoclonal antibody therapeutics to fill vacuum left by ineffective conventional therapies

Plant protein mimics hormone that mitigates diabetes and obesity

Vioxx could have caused 140000 excess cases of coronary heart disease in the USA since 1999

Vioxx withdrawal raises many questions concerning drug policy

More studies on risks and benefits of COX-2 inhibitors

Drug Discovery - Second Edition eBook

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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