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Zebrafish show effects of ionizing and UV radiation differ during embryo development

Adam Dicker, M.D., Ph.D., associate professor of radiation oncology at Jefferson Medical College of Thomas Jefferson University and Jefferson’s Kimmel Cancer Center in Philadelphia, Mary Frances McAleer, M.D., Ph.D., a resident in the Department of Radiation Oncology at Jefferson Medical College and their co-workers compared the effects on zebrafish embryos of two types of radiation – ionizing radiation, which is the kind given to patients for cancer treatment, and ultraviolet (UV) radiation, which comes naturally from the sun.

30 Mar 2004

Human Genome Sciences can begin cardiovascular disease research

Human Genome Sciences, Inc.announced today that it has received a clinical development milestone payment from its partner, GlaxoSmithKline, related to the initiation of Phase 1 clinical trials of 677116 for the treatment of cardiovascular disease. 677116 is a small-molecule inhibitor of lipoprotein-associated phospholipase A2 (Lp-PLA2), an enzyme associated with the formation of atherosclerotic plaques.

30 Mar 2004

Researchers find new purpose for existing drugs to suppress colon cancer metastasis, secure post-radiation brain function, and trick tumors

Drugs approved for treatment of specific maladies sometimes show unexpected benefits. Researchers at the 95th annual meeting of the American Association for Cancer Research demonstrated highlighted how some drugs may one day offer previously unforeseen benefits for patients.

30 Mar 2004

Alzheimer’s Association asks for $40 million in additional funding

The Alzheimer’s Association today called on the House of Representatives to provide $40 million in additional funding this year to the National Institutes of Health NIH) to support large-scale clinical trials for treatments that would slow or delay the progression of Alzheimer’s disease.

30 Mar 2004

New Australian collaboration to discover new drugs targeting epilepsy and anxiety

Bionomics Limited and Southern Cross University announced today that they had established a collaboration to discover new drugs targeting epilepsy and anxiety. Under the arrangement, Southern Cross University will provide Bionomics with extracts from its collection of Australian-based natural products, together with expertise in natural products chemistry.

30 Mar 2004

Enzyme called COX-2 may promote the development of ovarian tumors

Fox Chase Cancer Center scientists have identified how an enzyme called COX-2 may promote the development of ovarian tumors, adding further insight into the mechanism of COX-2 inhibitors and the prevention of this highly lethal disease. The data was presented today at the 95th Annual Meeting of the American Association for Cancer Research in Orlando, Fla.

29 Mar 2004

Almost half of all medicines globally are used irrationally according to WHO

Almost half of all medicines globally are used irrationally. This, say medicines experts at the World Health Organization (WHO), can have severe consequences: adverse drug reactions, drug resistance, protracted illness and even death. In addition, the financial cost incurred by individuals and governments due to irrational use is unnecessary and often extremely high, particularly in developing countries where patients often pay for medicines out of pocket.

29 Mar 2004

IPM takes over Microbicide development to protect against sexual transmission of HIV

International Partnership for Microbicides (IPM) today announced that it has reached a farsighted agreement with Tibotec Pharmaceuticals Ltd, a subsidiary of Johnson & Johnson. The aim is to develop the promising compound TMC120 as a safe and effective microbicide to help protect women from infection with HIV. This agreement marks the first collaboration in the microbicide field between a major healthcare company and a public-private partnership such as IPM.

29 Mar 2004

Comparative genomics to cast new light on other spirochete microbes

Three centuries after a pioneering Dutch microbiologist first observed the spiral-shaped oral pathogen Treponema denticola, scientists have deciphered the bacterium’s entire DNA sequence and used comparative genomics to cast new light on other spirochete microbes.

29 Mar 2004

Three of the world’s top women chemists visit UK to inspire young scientists

Three of the world’s top women chemists are visiting the UK this week (29 March - 2 April) to tour institutions and talk about their research with the aim of inspiring young scientists to emulate their achievements. The inaugural Rosalind Franklin International Lectureship Programme has been masterminded by Professor Susan Gibson, Imperial College London, who funded the initiative with her prize money from the Royal Society Rosalind Franklin Award.

29 Mar 2004

Halting the development of certain pancreatic, ovarian, colon and lung cancers may be possible with new therapy

By investigating a single molecule that influences cell growth, a research group in the Purdue Cancer Center, including Brian S. Henriksen, has gained new insight into the chain of events that make some cancer cells divide uncontrollably, insight that may eventually lead to a way to break that chain, stopping cancer in its tracks. The molecule, known as Icmt, has a critical role in the development of Ras, an ordinarily beneficial protein that tells a cell to divide. The research group has determined how to inhibit Icmt's influence on Ras, without which the protein cannot develop effectively into an instigator of cell growth.

28 Mar 2004

A simple dietary supplement may also help to prevent strokes

A simple dietary supplement may not only give relief to some of the more than 400,000 New Zealanders that suffer from the pain of migraine headaches, but may also help to prevent strokes.

28 Mar 2004

Renowned researchers, scientists share advances in prevention, diagnosis, therapy

Leading researchers are gathering today for the 95th Annual Meeting of the American Association for Cancer Research (AACR), the premier multidisciplinary assembly, which features the latest developments in basic, prevention, translational and clinical cancer research. The meeting occurs from March 27 – 31, 2004 at the Orlando Convention Center, Fla.

27 Mar 2004

St. John’s wort may interfere with cancer-fighting drug’s ability to prevent relapse in leukemia patients

St. John’s wort, an herb thought to be a safe, natural remedy for mild depression, may interfere with a powerful cancer-fighting drug’s ability to prevent relapse in leukemia patients, a University of Florida pharmacy researcher will report March 27 at the annual meeting of the American Society for Clinical Pharmacology and Therapeutics.

26 Mar 2004

A simple blood test could determine whether older women with diabetes would benefit from, or be harmed by, vitamin doses designed to protect their ailing hearts

A simple blood test could determine whether older women with diabetes would benefit from, or be harmed by, vitamin doses designed to protect their ailing hearts, according to researchers at the Technion-Israel Institute of Technology.

26 Mar 2004

Researchers have successfully grafted human breast tissue into the mammary glands of mice

The last few years have witnessed critical advances in breast cancer therapies. Still, the disease afflicts one in eight American women, and scientists have yet to develop a living model with which they can study the intricacies of human breast-tumor behavior.

26 Mar 2004

A common antibiotic used to treat arthritis and acne shows promise for limiting the severity of spinal cord and brain injuries

When a fall, car crash, bullet, or knife crushes or cuts a spinal cord, the injury does not stop there. Rather, tissues continue to discharge toxic chemicals for hours, even days and weeks. These chemicals kill and disable nerve cells some distance away from the core injury, compounding the damage and making rehabilitation more difficult or impossible.

26 Mar 2004

Bionomics files novel angiogenesis genes patent

Bionomics Limited has announced that it had filed a further international patent application that covers 496 proprietary angiogenesis drug targets. The international patent application applies to genes that Bionomics has identified using advanced technologies such as microarray and bioinformatics analyses. These technologies have enabled Bionomics to identify novel angiogenesis genes that have not been identified by other companies or research groups.

26 Mar 2004

Joint Research Collaboration to Predict 3-D Protein Structures and Support Drug Discovery

IBM today announced that the University at Buffalo (UB) Center of Excellence in Bioinformatics, The State University of New York, will use IBM technologies and research expertise to study the structure and behavior of human proteins. The outcome of this research could lead to more targeted drugs to treat diseases such as cancer, Alzheimer's, AIDS and multiple sclerosis.

25 Mar 2004

New Research Information on Tumor Necrosis Therapy

Researchers for Peregrine Pharmaceuticals presented today at the Strategic Research Institute’s Clinical-Stage Product Partnering Summit in La Jolla, CA a summary of clinical experience with Tumor Necrosis Therapy (TNT). The TNT technology is being developed in the U.S. and Europe by Peregrine under the trade name Cotara™. Over 200 patients have been treated with TNT world-wide and a TNT product has been approved to treat grade III or IV advanced lung cancer in the People’s Republic of China. A Cotara registration study for brain cancer has been approved by the U.S. Food and Drug Administration, and a Phase I colorectal cancer study is on-going at Stanford University Medical Center.

25 Mar 2004

Drugs News and Research

Zebrafish show effects of ionizing and UV radiation differ during embryo development

Human Genome Sciences can begin cardiovascular disease research

Researchers find new purpose for existing drugs to suppress colon cancer metastasis, secure post-radiation brain function, and trick tumors

Alzheimer’s Association asks for $40 million in additional funding

New Australian collaboration to discover new drugs targeting epilepsy and anxiety

Enzyme called COX-2 may promote the development of ovarian tumors

Almost half of all medicines globally are used irrationally according to WHO

IPM takes over Microbicide development to protect against sexual transmission of HIV

Comparative genomics to cast new light on other spirochete microbes

Three of the world’s top women chemists visit UK to inspire young scientists

Halting the development of certain pancreatic, ovarian, colon and lung cancers may be possible with new therapy

A simple dietary supplement may also help to prevent strokes

Renowned researchers, scientists share advances in prevention, diagnosis, therapy

St. John’s wort may interfere with cancer-fighting drug’s ability to prevent relapse in leukemia patients

A simple blood test could determine whether older women with diabetes would benefit from, or be harmed by, vitamin doses designed to protect their ailing hearts

Researchers have successfully grafted human breast tissue into the mammary glands of mice

A common antibiotic used to treat arthritis and acne shows promise for limiting the severity of spinal cord and brain injuries

Bionomics files novel angiogenesis genes patent

Joint Research Collaboration to Predict 3-D Protein Structures and Support Drug Discovery

New Research Information on Tumor Necrosis Therapy

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