Small Molecules News and Research

RSS

Scientists demonstrate an in vitro kidney model

Kidneys work to constantly filter blood and remove toxins from the body. Conditions such as chronic kidney disease are characterized by a reduced ability to perform this essential function.

14 Aug 2019

Researchers discover promising approach to silence HIV infection

Researchers from The University of Texas Medical Branch at Galveston have discovered a new potential medication that works with an HIV-infected person's own body to further suppress the ever present but silent virus that available HIV treatments are unable to combat.

6 Aug 2019

Sanofi exercises option to advance innovative Bispecific Small Molecule project

Exscientia, the world-leading Artificial Intelligence (AI)-driven drug discovery company, today announced that Sanofi has exercised its option to progress an innovative Bispecific Small molecule project it discovered as part of its new modality collaboration.

From Sanofi 6 Aug 2019

Understanding creation of antibiotic scaffolds could drive new class of antibiotics

Understanding how antibiotic scaffolds are constructed in nature can help scientists prospect for new classes of antibiotics through DNA sequencing and genome mining.

31 Jul 2019

Intestinal microbes may affect course of amyotrophic lateral sclerosis

Researchers at the Weizmann Institute of Science have shown in mice that intestinal microbes, collectively termed the gut microbiome, may affect the course of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease.

22 Jul 2019

Chemists discover a whole new class of microbial recipes

Microbes are master chefs of the biomolecular world; collectively, they harbor the ability to produce a vast array of unknown substances, some of which may have therapeutic or other useful properties.

22 Jul 2019

Sorting protein in neurons protects against neurodegenerative disorders

Like a sorting machine in an assembly line, a molecule known as VPS35 detects and removes defective proteins from neurons.

10 Jul 2019

Using NMR to Study Protein Structure, Dynamics and Mechanisms

Fábio Almeida describes how NMR can be used to elucidate protein structure and how this data can be applied to human disease.

From Bruker BioSpin - NMR, EPR and Imaging 4 Jul 2019

Hesperos' multi-organ model correctly determine cardiotoxic mechanisms

Hesperos Inc., pioneers of the "human-on-a-chip" in vitro system has announced the use of its innovative multi-organ model to successfully measure the concentration and metabolism of two known cardiotoxic small molecules over time, to accurately describe the drug behavior and toxic effects in vivo.

4 Jul 2019

UK charity invests £1 million to develop potential therapeutic for Parkinson's

Charity Parkinson's UK is partnering with NRG Therapeutics Ltd to discover and develop a potential drug that could safeguard dopamine cells that are damaged by Parkinson's and slow down the progression of the condition.

1 Jul 2019

Fecal miRNAs could provide clues to early inflammation found in chronic gut conditions

Small molecules found in fecal matter could provide clues to the early inflammation found in chronic gut conditions, such as intestinal bowel disease, and serve as new biomarkers for diagnosis, according to a study led by the Institute for Biomedical Sciences at Georgia State University.

28 Jun 2019

Study finds new cancer driver which is fast, furious and loud

The Fast and the Furious movie franchise meets the Fast N' Loud television series to define an oncogene that drives 35% of prostate cancers.

27 Jun 2019

Atomwise and Enamine launch 10 billion compound virtual drug screening initiative

Atomwise, Inc. today announced the launch of a 10 billion compound AI-powered virtual drug screening initiative, the 10-to-the-10 program, in collaboration with Enamine Ltd., the world’s largest chemical supplier.

25 Jun 2019

PhoreMost and C4XD sign neurodegeneration drug discovery collaboration agreement

PhoreMost Limited, the UK-based biopharmaceutical company dedicated to drugging ‘undruggable’ disease targets, and C4X Discovery Holdings plc, a pioneering drug discovery company, today announced they have signed a neurodegeneration drug discovery collaboration agreement.

From PhoreMost 25 Jun 2019