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MD Anderson and AstraZeneca to conduct multiple studies in ovarian, gynecologic cancers

The University of Texas MD Anderson Cancer Center and AstraZeneca today announced a multiyear strategic research collaboration to conduct multiple, parallel clinical and clinically related studies in ovarian and other gynecologic cancers with the aim of improving patient outcomes.

31 Jan 2015

Multiplexed testing for EGFR and ALK gene rearrangements may be cost-effective for NSCLC treatment

Multiplexed genetic screening for epidermal growth factor receptor (EGFR) and anaplastic lymphoma kinase (ALK) gene rearrangements and subsequent biomarker-guided treatment is cost-effective compared with standard chemotherapy treatment without any molecular testing in the metastatic non-small cell lung cancer (NSCLC) setting in the United States.

31 Jan 2015

Breast and lung cancer patients with low levels of TTP protein have poorer prognosis

Moffitt Cancer Center researchers have found that breast and lung cancer patients who have low levels of a protein called tristetraprolin (TTP) have more aggressive tumors and a poorer prognosis than those with high levels of the protein.

31 Jan 2015

Steroid use associated with five-fold increase of blood clots in IBD patients

Compared with biologic therapy, corticosteroid (steroid) use is associated with a nearly five-fold increase of venous thromboembolism in inflammatory bowel disease (IBD) patients, according to a new study1 in Clinical Gastroenterology and Hepatology, the official clinical practice journal of the American Gastroenterological Association.

30 Jan 2015

Unique project launched to identify effects of exercise on young people's hearts

A unique research project to identify the effects of exercise on young hearts has been announced today.

30 Jan 2015

Researchers receive $2.2M grant to study links between depression and cardiovascular disease in HIV patients

Jesse Stewart, Ph.D., associate professor of psychology in the School of Science at Indiana University-Purdue University Indianapolis, and two colleagues have received a $2.2 million National Institutes of Health grant to investigate the links between depression, depression treatment and cardiovascular disease in adults with HIV.

29 Jan 2015

Young Researcher's Meeting on Primary Ciliary Dyskinesia to be held in Bern, Switzerland

Primary ciliary dyskinesia (PCD) is a rare, genetically heterogeneous disorder that affects approximately 1 in 20,000 individuals.

29 Jan 2015

Scientists publish catalog of genetic mutations found in head and neck cancers

Scientists have published the first comprehensive catalog of genetic mutations and other abnormal changes found in 279 cancers of the head and neck, and have identified several broken molecular pathways that might be targeted by existing and future cancer drugs.

28 Jan 2015

CUMC evaluates impact, cost-effectiveness of implementing new hypertension guidelines

Full implementation of new hypertension guidelines could prevent 56,000 cardiovascular disease events (mostly heart attacks and strokes) and 13,000 deaths each year, without increasing overall health care costs, an analysis conducted by researchers at Columbia University Medical Center found.

28 Jan 2015

Researchers one step closer to identifying how lung cancer cells metastasize

Smoking is the leading cause of lung cancer, and it is estimated that more than 159,000 people in the United States died from the disease last year. Most of these deaths were because the cancer had spread to other organ sites. Following their recent discovery of a protein pathway, Moffitt Cancer Center researchers are one step closer to understanding how lung cancer cells metastasize.

28 Jan 2015

Chemotherapy plus radiation improves survival in R1 NSCLC patients

US researchers have identified a survival benefit of postoperative combination chemotherapy and radiation treatment in patients with non-small-cell lung cancer who have microscopically positive surgical margins, regardless of pathological stage.

28 Jan 2015

Alectinib active against leptomeningeal metastases in ALK-positive NSCLC

Patients with anaplastic lymphoma kinase-rearranged non-small-cell lung cancer who have leptomeningeal metastases may benefit from treatment with the second-generation ALK inhibitor alectinib, a case series suggests.

28 Jan 2015

VATS lobectomy best for NSCLC patient short-term outcomes

Video-assisted thoracoscopic surgery lobectomy offers better short-term outcomes for patients with early-stage non-small-cell lung cancer than open lobectomy, multi-institutional research confirms.

28 Jan 2015

Plasma EGFR mutation cfDNA predicts advanced lung cancer outcome

Monitoring plasma cell-free DNA levels of epidermal growth factor receptor mutations may indicate prognosis for patients with lung adenocarcinoma after EGFR–tyrosine kinase inhibitor therapy, research suggests.

28 Jan 2015

SRS fails to improve survival for NSCLC brain metastases patients

Phase III trial findings suggest that carrying out stereotactic radiosurgery before chemotherapy does not improve overall survival for non-small-cell lung cancer patients with asymptomatic brain metastases compared with chemotherapy alone.

28 Jan 2015

EGFR–TKI response worse in NSCLC patients with rare EGFR mutations

In patients with non-small-cell lung cancer, rare epidermal growth factor receptor mutations are associated with a poorer response to EGFR–tyrosine kinase inhibitors compared with frequently occurring ones, according to a study published in Lung Cancer.

28 Jan 2015

Manchester researcher discover novel way to eradicate cancer stem cells

A way to eradicate cancer stem cells, using the side-effects of commonly used antibiotics, has been discovered by a University of Manchester researcher following a conversation with his young daughter.

28 Jan 2015

ICU patients using ventilators could benefit from assistive communication tools

A new study reveals that more than half of patients in intensive care units (ICU) using ventilators to help them breathe could benefit from assistive communication tools.

28 Jan 2015

TGH develops unique new method to help high-risk patients receive a lung transplant

A unique new method to treat a specific group of patients who are at greater risk of rejecting a donor lung, allowing them to live longer after transplant without rejection, has been developed by the Toronto Lung Transplant Program at Toronto General Hospital, University Health Network.

28 Jan 2015

HCI researchers find cell mechanism that may trigger pancreatic cancer

Researchers at Huntsman Cancer Institute at the University of Utah have found that defects in how cells are squeezed out of overcrowded tissue to die, a process called extrusion, may be a mechanism by which pancreatic cancer begins. From these findings, they may have identified an effective way to reverse the defective extrusion's effects without destroying normal tissues nearby.

28 Jan 2015

Lungs News and Research

MD Anderson and AstraZeneca to conduct multiple studies in ovarian, gynecologic cancers

Multiplexed testing for EGFR and ALK gene rearrangements may be cost-effective for NSCLC treatment

Breast and lung cancer patients with low levels of TTP protein have poorer prognosis

Steroid use associated with five-fold increase of blood clots in IBD patients

Unique project launched to identify effects of exercise on young people's hearts

Researchers receive $2.2M grant to study links between depression and cardiovascular disease in HIV patients

Young Researcher's Meeting on Primary Ciliary Dyskinesia to be held in Bern, Switzerland

Scientists publish catalog of genetic mutations found in head and neck cancers

CUMC evaluates impact, cost-effectiveness of implementing new hypertension guidelines

Researchers one step closer to identifying how lung cancer cells metastasize

Chemotherapy plus radiation improves survival in R1 NSCLC patients

Alectinib active against leptomeningeal metastases in ALK-positive NSCLC

VATS lobectomy best for NSCLC patient short-term outcomes

Plasma EGFR mutation cfDNA predicts advanced lung cancer outcome

SRS fails to improve survival for NSCLC brain metastases patients

EGFR–TKI response worse in NSCLC patients with rare EGFR mutations

Manchester researcher discover novel way to eradicate cancer stem cells

ICU patients using ventilators could benefit from assistive communication tools

TGH develops unique new method to help high-risk patients receive a lung transplant

HCI researchers find cell mechanism that may trigger pancreatic cancer

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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