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Scientists uncover how proteins meet on the cell membrane

Scripps Research scientists have uncovered the workings of a critical process in cell survival. Their study, published recently in the Proceedings of the National Academy of Sciences, is the first to show exactly how a protein called talin activates another critical protein, called integrin, to do its job on the cell membrane.

11 Oct 2018

Phase 2 results on tazemetostat EZH2 inhibitor to be presented at ESMO 2018

Epizyme, Inc., a clinical-stage company developing novel epigenetic therapies, announced today that updated efficacy and safety data from the fully enrolled cohort of epithelioid sarcoma (ES) patients in its ongoing Phase 2 trial of tazemetostat will be presented in a poster discussion session at the European Society for Medical Oncology (ESMO) 2018 Congress to be held October 19-23 in Munich, Germany.

10 Oct 2018

Cancer cells hijack communication between fallopian tube and ovary to drive tumor growth

New research from the University of Illinois at Chicago shows that cancer cells in the fallopian tube affect normal chemical signaling between reproductive tissues and stimulate the release of norepinephrine, a small molecule hormone, from the ovary.

10 Oct 2018

Study: Sarcoma patients poorly informed about risk of interactions with anti-cancer drugs

Sarcoma patients show great openness to the use of complementary alternative medicines (CAMs) for supportive care, but they are poorly informed about safety issues and risk of interactions with anti-cancer drugs, a study to be presented at ESMO 2018 reported.

10 Oct 2018

Researchers successfully implant biomimetic hybrid prosthesis imitating bone structure

For the first time ever, a research team from the small innovative enterprise Biomimetix, implementing several NUST MISIS developments, has successfully implanted a biomimetic hybrid prosthesis imitating bone structure made from ultra-high molecular weight polyethylene and titanium alloy into a patient's femoral bone.

10 Oct 2018

Study identifies tumor cell population responsible for resistance to therapy and cancer relapse

Resistance to therapy is a major problem in cancer patients as the cells that resist to therapy is at the root of tumor relapse and is associated with high morbidity and mortality.

9 Oct 2018

Personal Genome Diagnostics’ pan-cancer assay being used in new clinical trial

Personal Genome Diagnostics, Inc., a leader in cancer genomics and pioneer in liquid biopsy, today reported that its non-invasive, pan-cancer plasma assay is being used in an important new clinical trial, Nivolumab, Ipilimumab in Patients With Hyper Mutated Cancers Detected in Blood, led by the Cancer Research Institute and Canadian Cancer Trials Group.

9 Oct 2018

Arcus Biosciences announces presentation of final results from Phase 1 study of AB928 at ESMO 2018

Arcus Biosciences, Inc., a clinical-stage biopharmaceutical company focused on creating innovative cancer immunotherapies, today announced that it will present final results from the Phase 1 study of AB928, its dual adenosine receptor antagonist, in healthy volunteers during a poster display session at the European Society of Medical Oncology 2018 Congress, being held October 19-23, 2018, in Munich, Germany.

8 Oct 2018

Cutting-edge precision medicine spreading from specialist cancer units to community setting

Nearly 1 in 4 patients with advanced cancer, treated at Comprehensive Cancer Care Network centers in the US, are receiving innovative drugs matched to DNA mutations in their tumors.

8 Oct 2018

Neoadjuvant clinical trial of immune checkpoint blockade for melanoma patients yields high response rate

Combination checkpoint blockade before surgery (neoadjuvant therapy) produced a high response rate among patients with high-risk stage 3 melanoma, with nearly half having no sign of disease at surgery, but a high incidence of side effects caused the trial to be closed early.

8 Oct 2018

Beyond BRCA: Epigenetic Silencing in Breast Cancer

An interview with Professor William Newman, discussing his recent discovery in the field of breast cancer research, and the options that this will provide for women who have a family history of breast cancer but test negative for BRCA1/2 mutations.

8 Oct 2018

NCCN adds COPIKTRA capsules to NCCN Guidelines for follicular lymphoma

Verastem, Inc., focused on developing and commercializing medicines to improve the survival and quality of life of cancer patients, today announced that the National Comprehensive Cancer Network added COPIKTRA (duvelisib) capsules to the Clinical Practice Guidelines in Oncology (NCCN Guidelines) for follicular lymphoma.

8 Oct 2018

New epigenetic screening method could improve cancer detection

Researchers have found a better way to determine the epigenetic code of DNA for the identification of disease, using enzymes instead of bisulphite.

8 Oct 2018

Immunotherapy effective for individuals with inherited form of skin cancer

Individuals with an inherited form of skin cancer often have a poor prognosis. The type of immunotherapy that was awarded this year's Nobel Prize in Physiology or Medicine is, however, particularly effective in this patient group, research from Karolinska Institutet in Sweden shows. The study is published in the Journal of Medical Genetics.

8 Oct 2018

Scientists discover new molecular pathway that controls colorectal cancer development

Scientists from the Cancer Science Institute of Singapore at the National University of Singapore have discovered a new molecular pathway that controls colorectal cancer development, and their exciting findings open new therapeutic opportunities.

8 Oct 2018

Loyola Medicine neurologist honored for showing exceptional support to Neurocritical Care Society

Loyola Medicine neurologist Michael Schneck, MD, is a 2018 recipient of a Presidential Citation from the Neurocritical Care Society in recognition of his extraordinary efforts on behalf of the society.

7 Oct 2018

Researchers develop cancer vaccine platform to improve efficacy of oncolytic enveloped viruses

Researchers at the Faculty of Pharmacy have developed PeptiENV, a cancer vaccine platform, which can be used to improve the therapeutic efficacy of oncolytic enveloped viruses currently in clinical use.

6 Oct 2018

Researchers receive $1.2 million grant to test potential treatment for metastatic breast cancer

A team of Medical University of South Carolina Hollings Cancer Center researchers received a three-year, $1.2 million grant from the U.S. Department of Defens to test a potential therapeutic antibody that could block breast cancer growth with fewer side effects, opening up potential for future drug development.

5 Oct 2018

Scripps Research scientists discover role of immune system double agent

Scientists at Scripps Research have discovered the role of an immune system double agent. This molecule, called USP18, can help curtail immune responses, but it can also open the door to bacterial infections, such as harmful listeria and staph infections.

5 Oct 2018

HalioDx announces availability of Brightplex, a high capacity IHC multiplex technology

HalioDx, an immuno-oncology company pioneering the immunological diagnosis of cancers, announces the availability of Brightplex, a novel high capacity IHC multiplex technology enabling multiple biomarkers to be analyzed on a single FFPE slide.

4 Oct 2018

Tumor News and Research

Scientists uncover how proteins meet on the cell membrane

Phase 2 results on tazemetostat EZH2 inhibitor to be presented at ESMO 2018

Cancer cells hijack communication between fallopian tube and ovary to drive tumor growth

Study: Sarcoma patients poorly informed about risk of interactions with anti-cancer drugs

Researchers successfully implant biomimetic hybrid prosthesis imitating bone structure

Study identifies tumor cell population responsible for resistance to therapy and cancer relapse

Personal Genome Diagnostics’ pan-cancer assay being used in new clinical trial

Arcus Biosciences announces presentation of final results from Phase 1 study of AB928 at ESMO 2018

Cutting-edge precision medicine spreading from specialist cancer units to community setting

Neoadjuvant clinical trial of immune checkpoint blockade for melanoma patients yields high response rate

Beyond BRCA: Epigenetic Silencing in Breast Cancer

NCCN adds COPIKTRA capsules to NCCN Guidelines for follicular lymphoma

New epigenetic screening method could improve cancer detection

Immunotherapy effective for individuals with inherited form of skin cancer

Scientists discover new molecular pathway that controls colorectal cancer development

Loyola Medicine neurologist honored for showing exceptional support to Neurocritical Care Society

Researchers develop cancer vaccine platform to improve efficacy of oncolytic enveloped viruses

Researchers receive $1.2 million grant to test potential treatment for metastatic breast cancer

Scripps Research scientists discover role of immune system double agent

HalioDx announces availability of Brightplex, a high capacity IHC multiplex technology

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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