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$94 million PCORI funding to support the next phase of PCORnet and new colorectal cancer study in older adults

The Patient-Centered Outcomes Research Institute Board of Governors today approved $61.3 million for a slate of several infrastructure projects that will support the activities of eight Clinical Research Networks to implement the next phase of PCORnet, the National Patient-Centered Clinical Research Network.

29 Sep 2021

Research uncovers how the guinea pig gut forms solid fecal pellets

New research from Flinders University has uncovered further details on how the guinea pig gut forms solid fecal pellets, providing potential insights that could help in the management of human bowel issues.

29 Sep 2021

Human coronavirus replicates in bats without using the spike protein

Researchers in Singapore have conducted a study showing active replication of a human coronavirus in bats that occurred without the viral spike protein binding to host cell receptors.

28 Sep 2021

Classic antidepressants show potential to enhance modern cancer treatments

Classic antidepressants could help improve modern cancer treatments. They slowed the growth of pancreatic and colon cancers in mice, and when combined with immunotherapy, they even stopped the cancer growth long-term.

28 Sep 2021

Location of brain metastasis is not random, study indicates

Brain metastasis occurs when cancer in one part of the body spreads to the brain. The lifetime incidence of such metastatic brain tumors in cancer patients is between 20%-45%, research shows.

23 Sep 2021

Scientists reveal the biological process leading to dangerous inflammatory disease in preemies

In a study with mice reported today in the journal Science Translational Medicine, a Johns Hopkins Medicine research team has provided what may be the most definitive view to date of the biological process leading to necrotizing enterocolitis (NEC), a dangerous inflammatory disease that can destroy a premature infant's intestinal lining and causes death in up to a third of the cases.

23 Sep 2021

Scientists discover how mucus protein emerges to disrupt airways of individuals with lung conditions

Mucus is an essential protective layer of gel-like liquid composed largely of proteins called mucins throughout our airways. One of them, called MUC5B, is crucial for the innate defense against the various things we inhale.

23 Sep 2021

Study examines racial differences in receipt of cancer screenings among women

Women who do not receive recommended cancer screenings are at a higher risk of morbidity and mortality. But why is it that some women are more likely to receive cancer screenings than others?

22 Sep 2021

Researchers uncover a molecular mechanism to inhibit aggravation of colitis

The intestinal microbial ecosystem includes diverse species of bacteria. These bacteria can produce bioactive metabolites that directly affect the host's immune system.

21 Sep 2021

Researchers reveal a mechanism of SHP2-mediated tumor immunosuppression

Colorectal cancer (CRC), a malignant tumor worldwide consists of microsatellite instability (MSI) and stable (MSS) phenotypes. Although SHP2 is a hopeful target for cancer therapy, its relationship with innate immunosuppression remains elusive. To address that, the authors of this article performed single-cell RNA sequencing to explore the role of SHP2 in all cell types of tumor microenvironment (TME) from murine MC38 xenografts.

21 Sep 2021

Systematic review focuses on women's health associated with menopausal hormone therapy

Treatment with estrogen in menopause is both good and bad for women's health. The picture is complex and the scientific evidence sometimes scanty or only moderately solid, a study shows. University of Gothenburg researchers took part.

20 Sep 2021

Commonly prescribed cholesterol-lowering drugs could be effective in treating ulcerative colitis

There may be good news for the nearly 1 million people battling ulcerative colitis, a type of inflammatory bowel condition with no real cure: Statins, a commonly prescribed cholesterol-lowering drug, seem to be an effective, if unexpected, treatment for the condition, according to a new Stanford Medicine study.

20 Sep 2021

Increased presence of certain bacteria in the gut may indicate colon cancer risk

A study published today in the journal Cell Host & Microbe reported that the increased presence of certain bacteria in a gut biome indicates a greater likelihood that colon polyps will become cancerous.

18 Sep 2021

Drug accumulation alters gut bacterial metabolism and composition

In a research paper recently published in the journal Nature by Klünemann et al. (September 8th, 2021), the interaction of 15 diverse drugs with 25 common strains of gut bacteria is investigated, revealing 70 bacteria-drug interactions that include 29 entirely novel mechanisms not yet reported.

15 Sep 2021

Colon News and Research

$94 million PCORI funding to support the next phase of PCORnet and new colorectal cancer study in older adults

Research uncovers how the guinea pig gut forms solid fecal pellets

Human coronavirus replicates in bats without using the spike protein

Classic antidepressants show potential to enhance modern cancer treatments

Location of brain metastasis is not random, study indicates

Scientists reveal the biological process leading to dangerous inflammatory disease in preemies

Scientists discover how mucus protein emerges to disrupt airways of individuals with lung conditions

Study examines racial differences in receipt of cancer screenings among women

Researchers uncover a molecular mechanism to inhibit aggravation of colitis

Researchers reveal a mechanism of SHP2-mediated tumor immunosuppression

Systematic review focuses on women's health associated with menopausal hormone therapy

Commonly prescribed cholesterol-lowering drugs could be effective in treating ulcerative colitis

Increased presence of certain bacteria in the gut may indicate colon cancer risk

Drug accumulation alters gut bacterial metabolism and composition

Researchers discover new pathway that makes drugs less effective in bowel cancer patients

Study introduces new surgical procedure to treat patients with congenital intestinal malrotation

Second- or third-degree relatives could influence a person's risk of developing colorectal cancer

Restoring beneficial gut microbes to enhance the efficacy of cancer immunotherapy

Colonoscopy retroflexion often poorly preformed in practice, study finds

New imaging technique uses photonics for early diagnosis of bowel cancer

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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