Nephrology News and Research

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Nephrology is a branch of internal medicine and pediatrics dealing with the study of the function and diseases of the kidney.

G protein-coupled receptors help humans taste, smell, and regulate mood and immunity

Dr. Guangyu Wu is dissecting the molecular homing that enables a nascent protein to ultimately find its way to the surface of a cell as a mature receptor type that helps us taste, smell and even regulate our mood and immunity.

14 Oct 2020

AncestryDNA modeling study of 500,000 Americans sheds light on COVID-19 risk factors

Now, a new study by researchers at AncestryDNA, a company that provides DNA testing services that use modern autosomal testing technology, shows that some people are more susceptible to COVID-19 infection, and they may experience more severe outcomes, including males, the elderly, and those with comorbidities.

14 Oct 2020

COVID-19 causes potentially damaging neurological injuries, study shows

Without directly invading the brain or nerves, the virus responsible for COVID-19 causes potentially damaging neurological injuries in about one in seven infected, a new study shows.

13 Oct 2020

Research shows 10 or more medications are prescribed to older heart failure patients

More than half of older patients hospitalized for heart failure, a progressive condition in which the heart doesn't pump blood as well as it should, are discharged from the hospital with prescriptions for 10 or more medications, according to new research published today in Circulation: Heart Failure, an American Heart Association journal.

13 Oct 2020

Study: Deaths recorded during pandemic is higher than those attributed to COVID-19

For every two deaths attributed to COVID-19 in the U.S., a third American dies as a result of the pandemic, according to new data publishing Oct. 12 in the Journal of the American Medical Association.

13 Oct 2020

Neoadjuvant trial of combination immunotherapy has favorable outcomes in bladder cancer patients

Neoadjuvant, or pre-surgical, combination treatment with the immune checkpoint inhibitors tremelimumab (anti-CTLA-4) and durvalumab (anti-PD-1) was well-tolerated and showed early signs of activity in certain patients with localized bladder cancer who do not have standard treatment options available, according to a Phase I clinical trial conducted by The University of Texas MD Anderson Cancer Center.

13 Oct 2020

Analysis of existing comorbidities and COVID-19 mortality

As the COVID-19 pandemic continues to spread, and research related to potential risk factors for COVID-19 mortality continues, it is becoming clear that individuals with underlying comorbidities have a greater risk of death from COVID-19. The exact contribution of different comorbidities is unclear, however. Now, a new study published in the journal PLOS ONE dissects this topic and may help to quantify the risk posed by specific conditions and offer help with the prognosis.

11 Oct 2020

Pathways contributing to hypercoagulability in severe SARS‐CoV‐2 patients

In a study by researchers explored the possible mechanisms of the clotting disorder, focusing on the role of hypoxia-related activation of coagulation factors; cytokine storm, activation of neutrophils, and the release of neutrophil extracellular traps.

11 Oct 2020

Exuberant activation of immune cells in severe COVID-19 resembles lupus

In severe cases of COVID-19, Emory researchers have been observing an exuberant activation of immune cells, resembling acute flares of systemic lupus erythematosus (SLE), an autoimmune disease.

9 Oct 2020

Certain pre-existing conditions may highly increase a patient's risk of dying from COVID-19

A large, international study of COVID-19 patients confirmed that cardiovascular disease, hypertension, diabetes, congestive heart failure, chronic kidney disease, stroke and cancer can increase a patient's risk of dying from the virus.

8 Oct 2020

Pre-existing conditions can increase patient's risk of dying from COVID-19

8 Oct 2020

Researchers create p16-Cre ERT2 -tdTomato mouse model to characterize in vivo senescent cells

Cell senescence is a state of permanent cell cycle arrest that was initially defined for cells grown in cell culture. It plays a key role in age-associated organ dysfunction and age-related diseases such as cancer, but the in vivo pathogenesis is largely unclear.

7 Oct 2020

Case report of arthritis in a COVID-19 patient

The current paper published in the The Lancet Rheumatology discusses arthritis in a 58-year-old white woman with COVID-19 of less than severe intensity.

7 Oct 2020

Study reveals potential utility of artemisinin-based treatments against SARS-CoV-2

In a recent, methodologically robust bioRXiv preprint paper, researchers from Germany, Denmark and Hong Kong report in vitro efficacy of extracts from the sweet wormwood plant (Artemisia annua), but also artemisinin, artesunate and artemether derivatives against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

6 Oct 2020

Less than 10% of US adults have SARS-CoV-2 antibodies

A new study by researchers at Stanford University and Ascend Clinical Laboratory and published in the journal The Lancet in September 2020 reports the prevalence of antibodies to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus in a dialysis patient population in the US.

5 Oct 2020

Study fails to establish independent risk factors for SARS-COV-2 infection in HIV patients

As the COVID-19 pandemic continues to spread worldwide, a new study published in the International Journal of Infectious Diseases in September 2020 reports that people with HIV infection are not at greater risk of COVID-19 compared to the general population.

5 Oct 2020

Quality services at healthcare facilities could reduce ‘devastating’ birth injury

The number of women in Uganda suffering from obstetric fistula will continue to rise if they go to local traditional healers because healthcare facilities with trained staff are inaccessible, a study warns.

5 Oct 2020

Furin cleavage site of SARS-CoV-2 spike glycoprotein enhances viral replication in the lungs

In a new bioRxiv* preprint paper, researchers from the Imperial College London, King's College London, and the University of Bristol in the United Kingdom show that the furin cleavage site of SARS-CoV-2 spike glycoprotein represents a key determinant for transmission among humans, as it substantially facilitates replication in airway cells - opening the door for the development of novel therapeutics.

4 Oct 2020

New study investigates hospital cardiac arrest in people with COVID-19 infection

Even when a sudden cardiac arrest happens inside a top hospital, where a code blue team is readily available, most people won't survive.

1 Oct 2020

Study reveals factors that increase risk of hospitalization and death in HIV patients diagnosed with COVID-19

Clinical trials are testing whether medications that treat human immunodeficiency virus (HIV) can also treat COVID-19, leading some patients with HIV to believe they might be protected against the coronavirus.

1 Oct 2020

Nephrology News and Research

Further Reading

G protein-coupled receptors help humans taste, smell, and regulate mood and immunity

AncestryDNA modeling study of 500,000 Americans sheds light on COVID-19 risk factors

COVID-19 causes potentially damaging neurological injuries, study shows

Research shows 10 or more medications are prescribed to older heart failure patients

Study: Deaths recorded during pandemic is higher than those attributed to COVID-19

Neoadjuvant trial of combination immunotherapy has favorable outcomes in bladder cancer patients

Analysis of existing comorbidities and COVID-19 mortality

Pathways contributing to hypercoagulability in severe SARS‐CoV‐2 patients

Exuberant activation of immune cells in severe COVID-19 resembles lupus

Certain pre-existing conditions may highly increase a patient's risk of dying from COVID-19

Pre-existing conditions can increase patient's risk of dying from COVID-19

Researchers create p16-Cre ERT2 -tdTomato mouse model to characterize in vivo senescent cells

Case report of arthritis in a COVID-19 patient

Study reveals potential utility of artemisinin-based treatments against SARS-CoV-2

Less than 10% of US adults have SARS-CoV-2 antibodies

Study fails to establish independent risk factors for SARS-COV-2 infection in HIV patients

Quality services at healthcare facilities could reduce ‘devastating’ birth injury

Furin cleavage site of SARS-CoV-2 spike glycoprotein enhances viral replication in the lungs

New study investigates hospital cardiac arrest in people with COVID-19 infection

Study reveals factors that increase risk of hospitalization and death in HIV patients diagnosed with COVID-19

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