Study fails to establish independent risk factors for SARS-COV-2 infection in HIV patients

As the COVID-19 pandemic continues to spread worldwide, a new study published in the International Journal of Infectious Diseases in September 2020 reports that people with HIV infection are not at greater risk of COVID-19 compared to the general population.

Low Proportion of HIV Patients Infected with COVID-19

The study, carried out at the Bichat University Hospital in Paris, covers over 5,300 people living with HIV (PLWHIV). Of these, only 0.5% (30 patients in all) were positive for the virus. Among this number, 70% were hospitalized for the disease, while 30% were outpatients.

Men and women made up 60% and 33% of this group, with ~7% being transgender. The median patient age was ~54 years, and over three-quarters were born out of France. About a third had cardiovascular disease, diabetes, and obesity, while less than a fifth had chronic kidney disease. This reflects the comorbidities most commonly seen in severe or critical COVID-19.

Two-thirds of the patients in this group were overweight, while only five had a Charlson comorbidity index of 3 or more. At the conclusion of the study, two patients had died (~7%), while four were still in hospital. The worst outcomes were observed in patients with a higher CCI score.

Overall, 3 needed mechanical ventilation. This is similar to that seen in other studies, but the mortality in this study was lower compared to 21% in other studies.

Favorable HIV Profile in Most Patients

The HIV infection was dormant in 90% of the patients, and of the remaining 3 patients, 2 had only a low HIV viral load. About three-quarters had a CD4 cell count above 500 cells/mm3. This suggests that other risk factors than HIV-induced immunosuppression were at work for COVID-19.

While 80% of the patients were positive for the viral RNA by polymerase chain reaction (PCR) testing, two were negative but had typical findings of COVID-19 on chest CT scanning. In 3 patients, the diagnosis was made based on anosmia or ageusia without a nasal swab at a median of 7 days from the onset of symptoms.

Treatment regimens had to be altered in only one patient due to the critical medical condition. About 16% of patients required additional antiviral treatment for COVID-19, mostly because of severe disease, requiring an oxygen flow of over 3 liters per minute.  The same number needed dexamethasone and tocilizumab.

Implications

The study concludes, “Risk factors were the same as those described in other SARS-COV2 series, suggesting that HIV infection is probably not an independent risk factor for covid-19 infection.”

Most of these patients were on effective anti-retroviral treatment and were virologically suppressed, with a high CD4 count. Further studies are required to establish the risk factors, the clinical outcomes, and treatment options in PLWHIV who contract COVID-19.

Journal reference:
Dr. Liji Thomas

Written by

Dr. Liji Thomas

Dr. Liji Thomas is an OB-GYN, who graduated from the Government Medical College, University of Calicut, Kerala, in 2001. Liji practiced as a full-time consultant in obstetrics/gynecology in a private hospital for a few years following her graduation. She has counseled hundreds of patients facing issues from pregnancy-related problems and infertility, and has been in charge of over 2,000 deliveries, striving always to achieve a normal delivery rather than operative.

Citations

Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Thomas, Liji. (2020, October 05). Study fails to establish independent risk factors for SARS-COV-2 infection in HIV patients. News-Medical. Retrieved on November 05, 2024 from https://www.news-medical.net/news/20201005/Study-fails-to-establish-independent-risk-factors-for-SARS-COV-2-infection-in-HIV-patients.aspx.

  • MLA

    Thomas, Liji. "Study fails to establish independent risk factors for SARS-COV-2 infection in HIV patients". News-Medical. 05 November 2024. <https://www.news-medical.net/news/20201005/Study-fails-to-establish-independent-risk-factors-for-SARS-COV-2-infection-in-HIV-patients.aspx>.

  • Chicago

    Thomas, Liji. "Study fails to establish independent risk factors for SARS-COV-2 infection in HIV patients". News-Medical. https://www.news-medical.net/news/20201005/Study-fails-to-establish-independent-risk-factors-for-SARS-COV-2-infection-in-HIV-patients.aspx. (accessed November 05, 2024).

  • Harvard

    Thomas, Liji. 2020. Study fails to establish independent risk factors for SARS-COV-2 infection in HIV patients. News-Medical, viewed 05 November 2024, https://www.news-medical.net/news/20201005/Study-fails-to-establish-independent-risk-factors-for-SARS-COV-2-infection-in-HIV-patients.aspx.

Comments

The opinions expressed here are the views of the writer and do not necessarily reflect the views and opinions of News Medical.
Post a new comment
Post

While we only use edited and approved content for Azthena answers, it may on occasions provide incorrect responses. Please confirm any data provided with the related suppliers or authors. We do not provide medical advice, if you search for medical information you must always consult a medical professional before acting on any information provided.

Your questions, but not your email details will be shared with OpenAI and retained for 30 days in accordance with their privacy principles.

Please do not ask questions that use sensitive or confidential information.

Read the full Terms & Conditions.

You might also like...
New insights into the mechanisms of efavirenz-induced neurotoxicity