Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

Designing antimalarials with multiple targeting mechanisms of action

Malaria remains a serious global health threat. While the current discoveries of antimalarials are almost totally focused on single mode-of-action inhibitors, multi-targeting inhibitors are highly desired to overcome the increasingly serious drug resistance.

18 Aug 2021

Researchers receive $26.5 million NIH grant to pursue a new strategy for curing HIV

Over the last 40 years, HIV has shifted from a deadly and mysterious virus to one that can be controlled with daily drugs. But attempts to completely eliminate the virus from the bodies of people living with HIV, curing them for good, have failed.

17 Aug 2021

Using self-assembled drugs to achieve a breakthrough in cancer therapy

One of the most challenging aspects of cancer treatment is the huge variety of different tumors that can occur with each one potentially requiring a different solution because unfortunately, one drug does not fit all.

17 Aug 2021

ERS Genomics and Cellular Engineering Technologies Enter CRISPR/Cas9 License Agreement

ERS Genomics Limited and Cellular Engineering Technologies today announced a non-exclusive license agreement.

17 Aug 2021

VPS29 gene facilitates coronavirus cell entry

In a research paper recently uploaded to the bioRxiv* preprint server by Poston et al. (August 8th, 2021), common host factors amongst several zoonotic pathogens are explored by CRISPR-Cas9 screening in human lung cells, focusing in particular on the betacoronavirus genus.

11 Aug 2021

New study describes SARS-CoV-2 ExoN enzyme that promotes antiviral resistance

A new study describes the structure of a crucial enzyme present in SARS-CoV-2.

8 Aug 2021

Study: Neglecting development of therapeutics may repeat history and replicate vaccine inequality

A new policy report released today by the global non-profit research and development organization Drugs for Neglected Diseases initiative (DNDi) highlights how the development of therapeutics has been relatively neglected in the global response to COVID-19 and warns that with the few treatment innovations available principally in high-income countries, we risk repeating history and replicating the vaccine inequality that has become a defining characteristic of this global pandemic.

6 Aug 2021

Specific and sensitive biomarker in the blood predicts symptomatic COVID-19 infection

Researchers remain perplexed as to why some patients infected with SARS-CoV-2, the virus responsible for COVID-19, remain asymptomatic while other patients develop severe disease symptoms.

5 Aug 2021

Rigaku Acquires Life Science Imaging Equipment Manufacturer MILabs

Rigaku Corporation (Headquarters: Akishima-shi, Tokyo; President: Toshiyuki Ikeda; "Rigaku"), a leading manufacturer of X-ray analysis equipment, has acquired all issued shares of MILabs B.V. (Headquarters: Houten, The Netherlands; CEO and CSO: Dr. Frederik Beekman; “MILabs”)

From Rigaku Corporation 4 Aug 2021

Next-Generation Sequencing and the Diagnosis of Disease

In this interview, Professor John Rossen talks about next-generation sequencing and it's implications for the diagnosis of disease.

From Tecan 4 Aug 2021

Discovery may enable the development of new therapies to kill aggressive cancer cells

Vanderbilt faculty and researchers are looking for the "Achilles' heel" of the cancer cells that survive initial chemotherapy.

3 Aug 2021

NSF awards $441,028 to address the workforce needs of regenerative medicine

Regenerative medicine is a cross-disciplinary field that aims to repair or replace abnormal organs by growing tissues in the laboratory or cells for therapy.

3 Aug 2021

What is the potential of microphysiological systems in COVID-19 research?

In a recently published review article in the journal Drug Discovery Today, scientists have described the utility of human-based microphysiological systems MPSs in understanding the pathophysiology of SARS-CoV-2 infection and developing effective therapeutic interventions. Moreover, they have described the establishment of a global working group to synchronize recent developments around MPSs and COVID-19 research.

3 Aug 2021

Latin American and Caribbean research contributions to tackle challenges posed by brain diseases

Every year there are nearly ten million new cases of dementia globally, of which Alzheimer's Disease (AD) is the most common form, accounting for around 60-70% of cases.

2 Aug 2021

Next generation automation lab achieves huge productivity gains

Eli Lilly and Company and their industry partners, including sample management specialists – Ziath, are speeding the discovery of new medicines through the fully automated Lilly Life Sciences Studio lab in San Diego, USA.

From Ziath Ltd 30 Jul 2021

Study could lead to blood-based diagnostic test for schizophrenia

Scientists at Sanford Burnham Prebys have discovered how levels of a protein could be used in the future as a blood-based diagnostic aid for schizophrenia.

27 Jul 2021

Metrion Biosciences appoints Nick Foster as Chief Commercial Officer and Head of Global Business Development

Metrion today announced the appointment of Nick Foster as Chief Commercial Officer and Head of Global Business Development.

26 Jul 2021

Researchers identify an unexpected effect for already characterized active substances

Every innovative drug starts with the search for an active substance targeting key players in disease-related processes.

23 Jul 2021

ATN framework can be extended to detect frontotemporal degeneration

Alzheimer's disease and related diseases can still only be confirmed in deceased patients' brains via autopsy.

20 Jul 2021

Researchers use appendiceal cancer organoids to study personalized immunotherapy response

Wake Forest researchers and clinicians are using patient-specific tumor 'organoid' models as a preclinical companion platform to better evaluate immunotherapy treatment for appendiceal cancer, one of the rarest cancers affecting only 1 in 100,000 people.

19 Jul 2021

Drug Discovery News and Research

Further Reading

Designing antimalarials with multiple targeting mechanisms of action

Researchers receive $26.5 million NIH grant to pursue a new strategy for curing HIV

Using self-assembled drugs to achieve a breakthrough in cancer therapy

ERS Genomics and Cellular Engineering Technologies Enter CRISPR/Cas9 License Agreement

VPS29 gene facilitates coronavirus cell entry

New study describes SARS-CoV-2 ExoN enzyme that promotes antiviral resistance

Study: Neglecting development of therapeutics may repeat history and replicate vaccine inequality

Specific and sensitive biomarker in the blood predicts symptomatic COVID-19 infection

Rigaku Acquires Life Science Imaging Equipment Manufacturer MILabs

Next-Generation Sequencing and the Diagnosis of Disease

Discovery may enable the development of new therapies to kill aggressive cancer cells

NSF awards $441,028 to address the workforce needs of regenerative medicine

What is the potential of microphysiological systems in COVID-19 research?

Latin American and Caribbean research contributions to tackle challenges posed by brain diseases

Next generation automation lab achieves huge productivity gains

Study could lead to blood-based diagnostic test for schizophrenia

Metrion Biosciences appoints Nick Foster as Chief Commercial Officer and Head of Global Business Development

Researchers identify an unexpected effect for already characterized active substances

ATN framework can be extended to detect frontotemporal degeneration

Researchers use appendiceal cancer organoids to study personalized immunotherapy response

ELRIG Drug Discovery: Poster Sessions eBook

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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