Drug Discovery News and Research

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The drug discovery process begins with recognizing a disease or clinical condition in which there is a lack of adequate medical treatment. Once a potential drug has been identified, pre-clinical research can begin. This process includes several stages; the first of which involves identifying and validating the prospective drug’s target through assay development, high throughput screening, hit identification and finally, lead optimization. Once the pre-clinical process is complete, the newly synthesized drug candidate is selected for future clinical development.

Research opens alternative therapeutic avenues for treatment of chronic pain

Building on previous findings, scientists have demonstrated that conolidine interacts with the newly identified opioid receptor ACKR3/CXCR7.

3 Jun 2021

Scientists identify many existing drugs with antiviral activity against coronavirus

Mining the world's most comprehensive drug repurposing collection for COVID-19 therapies, scientists have identified 90 existing drugs or drug candidates with antiviral activity against the coronavirus that's driving the ongoing global pandemic.

3 Jun 2021

Researchers develop rapid antibody screening method for novel COVID-19 therapeutics development

New research undertaken by researchers in the USA describes two parallel but distinct in vivo approaches for the accelerated discovery of antibodies targeting SARS-CoV-2 spike protein.

3 Jun 2021

Known pharmaceutical compounds could provide new therapies for COVID-19

After screening over 12,000 existing treatments, researchers have found many promising antiviral compounds that could treat COVID-19.

3 Jun 2021

New process could reinvigorate the search for natural product drugs to treat cancers, viral infections

Researchers from Carnegie Mellon University's Computational Biology Department in the School of Computer Science have developed a new process that could reinvigorate the search for natural product drugs to treat cancers, viral infections and other ailments.

3 Jun 2021

Pseudomonas aeruginosa poses a serious threat to human health

No one knows exactly when humans and pathogenic bacteria were encountered with each other. But since then, the war began over life and survival between them. During this time, both sides of the war tried to equip themselves with all their might.

2 Jun 2021

NUS researchers develop a way to automate the production of pharmaceutical small molecules

The discovery and development of new small-molecule compounds for therapeutic use involves a huge investment of time, effort and resources.

1 Jun 2021

Review: Sulfur-containing natural products isolated from marine organisms

Announcing a new publication for Marine Life Science & Technology journal. In this review article the authors Yang Hai, Mei‑Yan Wei, Chang‑Yun Wang, Yu‑Cheng Gu and Chang‑Lun Shao from Ocean University of China, Qingdao, China and Syngenta Jealott's Hill International Research Centre, Berkshire, UK consider the chemistry and biology of sulfur‑containing natural products from marine microorganisms.

31 May 2021

Parents and young adults urged to get HPV vaccination back on track

Sanford Burnham Prebys has joined doctors and scientists across America at National Cancer Institute (NCI)-designated cancer centers and other organizations to issue a joint statement urging the nation's physicians, parents and young adults to get the human papillomavirus (HPV) vaccination back on track.

21 May 2021

Biognosys Announces the Appointment of Kristina Beeler as Chief Business Officer

Biognosys announces the appointment of Kristina Beeler as Chief Business Operator

From Biognosys 21 May 2021

Targeting mTOR pathway can improve the effectiveness of chemotherapies for pediatric brain cancer

Two experimental drug approaches that target vulnerabilities in cancer cell metabolism may extend survival and enhance the effectiveness of standard chemotherapies for a highly aggressive type of pediatric brain cancer.

21 May 2021

Photosynthesis of Chiral Building Blocks for Drug Discovery

A new white paper, written by scientists at Liverpool ChiroChem (LCC), describes how the Asynt Illumin8 parallel photoreactor is being used to synthesise a range of new 2-Aryl N-Heterocycles.

From Asynt 19 May 2021

Expert panel provides guidance for optimized design of early drug trials for Alzheimer's, related dementias

An expert panel convened by the Alzheimer's Drug Discovery Foundation (ADDF) and The Association for Frontotemporal Degeneration (AFTD) provides guidance on best practices for the design of early drug trials for Alzheimer's disease, frontotemporal degeneration (FTD), and other neurodegenerative dementias.

19 May 2021

Study shows how biases could be perpetuated by AI devices

Clinicians and surgeons are increasingly using medical devices based on artificial intelligence. These AI devices, which rely on data-driven algorithms to inform health care decisions, presently aid in diagnosing cancers, heart conditions and diseases of the eye, with many more applications on the way.

18 May 2021

Nanopore analysis identifies pseudouridine modifications in SARS-CoV-2

In a paper recently uploaded to the preprint server bioRxiv* by Fleming, Mathewson & Burrows (May 10th, 2021), nanopore devices are developed that allow identification of the passage of pseudouridine through a protein sensor. This further allowed the group to identify five conserved pseudouridine sites on the 3’ end of SARS-CoV-2 sub-genomic RNAs, which could potentially be beneficial to the virus in immune evasion.

17 May 2021

SARS-CoV-2 Nsp2 structure revealed by cryo-EM and AI

Researchers in the United States analyzed the non-structural protein 2 (Nsp2) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in order to better understand its function and to guide future drug discovery. The research paper is currently available on bioRxiv* preprint server.

16 May 2021

Researchers identify new compound that may prevent cardiac arrhythmia risk from common drugs

Dozens of commonly used drugs, including antibiotics, antinausea and anticancer medications, have a potential side effect of lengthening the electrical event that triggers contraction, creating an irregular heartbeat, or cardiac arrhythmia called acquired Long QT syndrome.

14 May 2021

Drug Discovery News and Research

Further Reading

Research opens alternative therapeutic avenues for treatment of chronic pain

Scientists identify many existing drugs with antiviral activity against coronavirus

Researchers develop rapid antibody screening method for novel COVID-19 therapeutics development

Known pharmaceutical compounds could provide new therapies for COVID-19

New process could reinvigorate the search for natural product drugs to treat cancers, viral infections

Pseudomonas aeruginosa poses a serious threat to human health

NUS researchers develop a way to automate the production of pharmaceutical small molecules

Review: Sulfur-containing natural products isolated from marine organisms

Parents and young adults urged to get HPV vaccination back on track

Biognosys Announces the Appointment of Kristina Beeler as Chief Business Officer

Targeting mTOR pathway can improve the effectiveness of chemotherapies for pediatric brain cancer

Photosynthesis of Chiral Building Blocks for Drug Discovery

Expert panel provides guidance for optimized design of early drug trials for Alzheimer's, related dementias

Study shows how biases could be perpetuated by AI devices

Nanopore analysis identifies pseudouridine modifications in SARS-CoV-2

SARS-CoV-2 Nsp2 structure revealed by cryo-EM and AI

Researchers identify new compound that may prevent cardiac arrhythmia risk from common drugs

Study examines a pathway responsible for the formation of tau tangles in the brain

Researchers develop a hairpin-shaped bicyclic peptide to fight cancer

The FDA expands collaboration with CN Bio to investigate lung-on-a-chip model for inhaled drug evaluation applications

eBook: Using iPSCs models for human disease research and drug discovery eBook

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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