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Researchers to test a promising treatment for high-risk COVID-19 outpatients

The nation has been coping with the pandemic for more than a year, and in this time, researchers have learned a great deal about how to treat COVID-19.

6 Apr 2021

Women experienced high rates of mental health problems early in COVID-19 pandemic

A study at the University of Chicago Medicine found U.S. women experienced increased incidence of health-related socioeconomic risks (HRSRs), such as food insecurity and interpersonal violence, early in the COVID-19 pandemic.

6 Apr 2021

New nanoparticle SARS-CoV-2 vaccine confers robust protection with single dose after two weeks

In a methodologically ‘state-of-the-art’ approach, US researchers have developed a protein-based nanoparticle vaccine against coronavirus disease (COVID-19), with a swift generation of antibodies and the potential to protect individuals who cannot receive other COVID-19 vaccines for medical reasons. The research is posted to the bioRxiv* preprint server.

5 Apr 2021

Phase 1 clinical study of unique vaccine to protect against COVID-19 begins

A unique vaccine to protect against COVID-19 begins clinical testing Tuesday, 6 April, at the Walter Reed Army Institute of Research (WRAIR), part of the U.S. Army Medical Research and Development Command.

5 Apr 2021

Can universal vaccines and treatments against future SARS-CoV-2 variants be developed?

A team of researchers from Saudi Arabia and Spain recently quantified the rapid evolution of SARS-CoV-2 by tracking the mutations of the virus globally, focusing on the receptor-binding domain (RBD) of the virus’s spike protein, which determines its infectivity.

5 Apr 2021

Researchers Identify potent small molecule inhibitors against SARS-CoV-2

A team of scientists from the USA and Sweden has recently screened 8 million small molecule inhibitors against SARS-CoV-2.

5 Apr 2021

SARS-CoV-2 cryptic transmission modeling shows emergence of first wave in US and Europe

To analyze this cryptic transmission phase and the first wave of the pandemic that ensued, researchers from Italy, UK, and the US used a data-driven, spatial, stochastic, and age-structured epidemic model. They developed a mechanistic understanding of the evolution of the epidemic and estimated the time required for local transmission in various states and countries. The model developed by the team offers a statistical idea of SARS-CoV-2 introductions across European countries and many states in the US.

5 Apr 2021

The use of mammalian cell surface display for rapid characterization of SARS-CoV-2 variants

A research group from the U.S. demonstrated the practicality of a spike display system in order to accelerate vaccine design, but also to swiftly appraise the effects of mutations in emerging strains of the SARS-CoV-2.

5 Apr 2021

RNA-binding cylinders inhibit SARS-CoV-2 replication in vitro

Research led by Michael J. Hannon from the University of Birmingham, UK, finds metallo-supramolecular helicates (cylinders) binding to untranslated regions of SARS-CoV-2 suppresses viral replication. The untranslated regions (UTR) of the viral genome could serve as drug targets for antiviral treatment.

5 Apr 2021

Research surveys hygiene practices in food supply chains during COVID-19 pandemic

Researchers survey hygiene procedures in food supply chains implemented during the COVID-19 pandemic.

5 Apr 2021

FIND announces launch of a request for proposals to expand access to COVID-19 testing services

The Foundation for Innovative New Diagnostics (FIND) announced today the launch of a request for proposals (RFP) to accelerate the development, manufacturing, and market availability of accurate, affordable, quality-assured and easy-to-use SARS-CoV-2 self-tests for use in low- and middle-income countries (LMICs).

5 Apr 2021

Chemical inhibitor can reduce SARS-CoV-2's ability to infect host cell lines

James McKerrow, MD, PhD, dean of the Skaggs School of Pharmacy and Pharmaceutical Sciences at University of California San Diego, has long studied neglected tropical diseases -- chronic and disabling parasitic infections that primarily affect poor and underserved communities in developing nations.

3 Apr 2021

Massive X-ray screening identifies several candidates for drugs against novel coronavirus

A team of researchers has identified several candidates for drugs against the coronavirus SARS-CoV-2 at DESY´s high-brilliance X-ray lightsource PETRA III.

3 Apr 2021

Prioritization of COVID-19 vaccines saves lives, reduces spread of infection

Waiting for your turn can be frustrating, especially when it comes to COVID-19 vaccinations. But prioritizing who receives the limited supply of vaccines available saves lives and reduces spread of infection, according to a study published today in the journal PNAS from the University of California, Davis.

2 Apr 2021

Scientists identify nine potential new COVID-19 treatments

A team led by scientists in the Perelman School of Medicine at the University of Pennsylvania has identified nine potential new COVID-19 treatments, including three that are already approved by the Food and Drug Administration (FDA) for treating other diseases.

2 Apr 2021

Higher B.1.1.7 transmission in households than other SARS-CoV-2 variants

Contact tracing data from a new preprint study on the medRxiv* preprint server provides further evidence that the B.1.1.7 variant — first reported in the United Kingdom — has a high transmission rate. The research, led by Birgitte Freiseleben de Blasio from the Norwegian Institute of Public Health and the University of Oslo in Norway, estimates B.1.1.7 has a 60% greater transmission within households than other severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern.

2 Apr 2021

Study finds CD8+ T cell responses detect all major SARS-CoV-2 variants

There have been concerns that several SARS-CoV-2 variants have mutations that allow them to evade the immune system. A new study published in the Open Forum Infectious Diseases suggests otherwise. Led by Aaron AR Tobian of Johns Hopkins University School of Medicine, results showed that except for one from the B.1.351 variant, CD8+ T cells showed a broad response to all SARS-CoV-2 variants.

2 Apr 2021

Long-COVID-19 is a significant risk in recovered patients post-hospitalization

A new study, which appeared in the British Medical Journal, reports on a retrospective study to examine the incidence and risk factors for ‘long COVID-19’, the term used to describe the long-term effects of COVID-19 on affected individuals.

2 Apr 2021

Proper choice of control group nullifies most observed genetic markers for severe COVID-19, study suggests

A new study deals with the genetic contribution to severe disease following infection with this virus, showing that the association of severity with specific human genes described in an earlier study is not obvious.

2 Apr 2021

Researchers offer large-scale screening of potential broad-spectrum SARS-CoV-2 antivirals

A new study describes the identification of new compounds from a library, with inhibitory activity against several coronaviruses. This study shows the utility of this method, besides identifying compounds that not only inhibit viral shedding in SARS-CoV-2 cultures, but have an immunomodulatory effect that may be useful in mitigating the damaging cytokine storm typical of severe or critical COVID-19.

2 Apr 2021

SARS News and Research

Researchers to test a promising treatment for high-risk COVID-19 outpatients

Women experienced high rates of mental health problems early in COVID-19 pandemic

New nanoparticle SARS-CoV-2 vaccine confers robust protection with single dose after two weeks

Phase 1 clinical study of unique vaccine to protect against COVID-19 begins

Can universal vaccines and treatments against future SARS-CoV-2 variants be developed?

Researchers Identify potent small molecule inhibitors against SARS-CoV-2

SARS-CoV-2 cryptic transmission modeling shows emergence of first wave in US and Europe

The use of mammalian cell surface display for rapid characterization of SARS-CoV-2 variants

RNA-binding cylinders inhibit SARS-CoV-2 replication in vitro

Research surveys hygiene practices in food supply chains during COVID-19 pandemic

FIND announces launch of a request for proposals to expand access to COVID-19 testing services

Chemical inhibitor can reduce SARS-CoV-2's ability to infect host cell lines

Massive X-ray screening identifies several candidates for drugs against novel coronavirus

Prioritization of COVID-19 vaccines saves lives, reduces spread of infection

Scientists identify nine potential new COVID-19 treatments

Higher B.1.1.7 transmission in households than other SARS-CoV-2 variants

Study finds CD8+ T cell responses detect all major SARS-CoV-2 variants

Long-COVID-19 is a significant risk in recovered patients post-hospitalization

Proper choice of control group nullifies most observed genetic markers for severe COVID-19, study suggests

Researchers offer large-scale screening of potential broad-spectrum SARS-CoV-2 antivirals

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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