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Scientists create animal models by altering specific genes associated with a given disease

Whitehead Institute Founding Member Rudolf Jaenisch, who helped transform the study of genetics by creating the first transgenic mouse in 1974, is again revolutionizing how genetically altered animal models are created and perhaps even redefining what species may serve as models.

6 May 2013

Rare mutation confers high risk of osteoporosis and certain cancers

deCODE genetics (an Amgen subsidiary) and Illumina, global leaders in analyzing and understanding the human genome, together with scientists from the National Hospital of Iceland and the University of Iceland reported today in the journal Nature the identification of a rare nonsense mutation that confers high risk of osteoporosis and osteoporosis related traits.

6 May 2013

Researchers describe alterations in long noncoding RNA sequences in Rett syndrome

Researchers at the Epigenetics and Cancer Biology Program at IDIBELL led by Manel Esteller, ICREA researcher and professor of genetics at the University of Barcelona, have described alterations in noncoding long chain RNA sequences in Rett syndrome.

3 May 2013

New approach could democratize viral surveillance, says UCSF scientist

The tick-borne Lone Star virus has been conclusively identified as part of a family of other tick-borne viruses called bunyaviruses, which often cause fever, respiratory problems and bleeding, according to new research led by scientists at UC San Francisco.

3 May 2013

Study may help diagnose endometrial cancer and lead to new drug development

Endometrial tumors can be reclassified into distinct subtypes based partly on their genomic makeup and may respond to targeted drugs already being tested in clinical trials, according to a large-scale genomic analysis led by researchers at Memorial Sloan-Kettering Cancer Center and other centers within The Cancer Genome Atlas (TCGA) Research Network.

2 May 2013

Powerful data-sifting algorithms help untangle complex genetics of cancer

Powerful data-sifting algorithms developed by computer scientists at Brown University are helping to untangle the profoundly complex genetics of cancer.

2 May 2013

Genomics-based testing could change recommended course of treatment for endometrial cancer

The most in-depth look yet at endometrial cancer shows that adding genomics-based testing to the standard diagnostic workup could change the recommended course of treatment for some women.

2 May 2013

Scientists study repeating patterns in nature to better understand role of immune system in cancer

Can the patterns in tree branches or the meandering bends in a river provide clues that could lead to better cancer therapies? According to a new study from Virginia Commonwealth University Massey Cancer Center, these self-similar, repeating patterns in nature known as fractals help scientists better understand how the immune system is organized and may one day be used to help improve stem cell transplant outcomes in leukemia patients by predicting the probability of transplant complications.

2 May 2013

Research findings pave the way for developing better treatments for AML

A team of researchers led by Washington University School of Medicine in St. Louis has identified virtually all of the major mutations that drive acute myeloid leukemia, a fast-growing blood cancer in adults that often is difficult to treat.

2 May 2013

Findings set the stage for identifying potential new drug targets, treatment strategies for AML

nvestigators for The Cancer Genome Atlas Research Network have detailed and broadly classified the genomic alterations that frequently underlie the development of acute myeloid leukemia, a deadly cancer of the blood and bone marrow.

2 May 2013

Wistar researchers find surprising role for RNA-editing protein in gene silencing

RNA, once considered a bit player in the grand scheme by which genes encode protein, is increasingly seen to have a major role in human genetics.

2 May 2013

Details about genomic landscapes of AML and endometrial cancer revealed

Two studies from The Cancer Genome Atlas program reveal details about the genomic landscapes of acute myeloid leukemia and endometrial cancer.

2 May 2013

Analysis identifies 37 RNA molecules that might predict survival in breast cancer patients

A Big Data analysis that integrates three large sets of genomic data available through The Cancer Genome Atlas has identified 37 RNA molecules that might predict survival in patients with the most common form of breast cancer.

30 Apr 2013

Transgene announces pre-clinical data of TG1050 for treatment of chronic hepatitis B infection

Transgene SA, a biopharmaceutical company that develops targeted immunotherapy products to treat major unmet medical needs in cancer and chronic infectious diseases, announced pre-clinical data obtained with its novel immunotherapeutic, TG1050, to treat chronic hepatitis B infection.

29 Apr 2013

New methods boost researchers' analytical powers by incorporating prior knowledge about SNPs function

As scientists probe and parse the genetic bases of what makes a human a human (or one human different from another), and vigorously push for greater use of whole genome sequencing, they find themselves increasingly threatened by the unthinkable: Too much data to make full sense of.

26 Apr 2013

CNIO researcher captures panoramic photo of proteins that take part in human DNA replication

The Genomic Instability Group led by researcher -scar Fern-ndez-Capetillo at the Spanish National Cancer Research Centre (CNIO), has for the first time obtained a panoramic photo of the proteins that take part in human DNA division, a process known as replication.

26 Apr 2013

Novel strategy for characterizing RNAs transported from nerve cell to synapse

Despite decades of research, relatively little is known about the identity of RNA molecules that are transported as part of the molecular process underpinning learning and memory.

26 Apr 2013

Researchers discover gene that can cause 3 different diseases depending on its alteration

An international research consortium led by the Universitat Aut-noma de Barcelona (UAB), the CIBERER and the University of Wurzburg (Germany) has discovered a gene that can cause three totally different diseases, depending on how it is altered.

26 Apr 2013

Study reveals a new way for detecting colorectal cancers

A unique new study led by University of Kentucky Markey Cancer Center researchers Guo-Min Li and Libya Gu, in collaboration with Dr. Wei Yang at National Institutes of Health, reveals a novel mechanism explaining the previously unknown root cause of some forms of colorectal cancers.

26 Apr 2013

Calcipotriol drug offers a potential treatment option for fibrotic diseases

Liver fibrosis results from an excessive accumulation of tough, fibrous scar tissue and occurs in most types of chronic liver diseases. In industrialized countries, the main causes of liver injury leading to fibrosis include chronic hepatitis virus infection, excess alcohol consumption and, increasingly, nonalcoholic steatohepatitis (NASH).

26 Apr 2013

Genome News and Research

Scientists create animal models by altering specific genes associated with a given disease

Rare mutation confers high risk of osteoporosis and certain cancers

Researchers describe alterations in long noncoding RNA sequences in Rett syndrome

New approach could democratize viral surveillance, says UCSF scientist

Study may help diagnose endometrial cancer and lead to new drug development

Powerful data-sifting algorithms help untangle complex genetics of cancer

Genomics-based testing could change recommended course of treatment for endometrial cancer

Scientists study repeating patterns in nature to better understand role of immune system in cancer

Research findings pave the way for developing better treatments for AML

Findings set the stage for identifying potential new drug targets, treatment strategies for AML

Wistar researchers find surprising role for RNA-editing protein in gene silencing

Details about genomic landscapes of AML and endometrial cancer revealed

Analysis identifies 37 RNA molecules that might predict survival in breast cancer patients

Transgene announces pre-clinical data of TG1050 for treatment of chronic hepatitis B infection

New methods boost researchers' analytical powers by incorporating prior knowledge about SNPs function

CNIO researcher captures panoramic photo of proteins that take part in human DNA replication

Novel strategy for characterizing RNAs transported from nerve cell to synapse

Researchers discover gene that can cause 3 different diseases depending on its alteration

Study reveals a new way for detecting colorectal cancers

Calcipotriol drug offers a potential treatment option for fibrotic diseases

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