Small Molecules News and Research

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Single dose restores normal cellular signaling in mouse model of autism

In a further test of a novel theory that suggests autism is the consequence of abnormal cell communication, researchers at the University of California, San Diego School of Medicine report that an almost century-old drug approved for treating sleeping sickness also restores normal cellular signaling in a mouse model of autism, reversing symptoms of the neurological disorder in animals that were the human biological age equivalent of 30 years old.

18 Jun 2014

Proteins causing daytime sleepiness also play crucial role in bone formation

Orexin proteins, which are blamed for spontaneous daytime sleepiness, also play a crucial role in bone formation, according to findings by UT Southwestern Medical Center researchers.

13 Jun 2014

New self-assembling nanoparticle arrays can form highly ordered thin film in 1 minute

The days of self-assembling nanoparticles taking hours to form a film over a microscopic-sized wafer are over. Researchers with the U.S. Department of Energy (DOE)'s Lawrence Berkeley National Laboratory (Berkeley Lab) have devised a technique whereby self-assembling nanoparticle arrays can form a highly ordered thin film over macroscopic distances in one minute.

10 Jun 2014

New targets could increase effectiveness and reduce side effects linked with breast cancer treatments

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have found new targets for potential intervention in breast cancer. These new targets could eventually increase effectiveness and reduce the undesirable side effects associated with current treatments.

6 Jun 2014

Brain circuit problem may contribute to auditory hallucinations of schizophrenia

St. Jude Children's Research Hospital scientists have identified problems in a connection between brain structures that may predispose individuals to hearing the "voices" that are a common symptom of schizophrenia. The work appears in the June 6 issue of the journal Science.

6 Jun 2014

Scientists identify new way to reactivate latent HIV

A team of scientists at the Gladstone Institutes has identified a new way to make latent HIV reveal itself, which could help overcome one of the biggest obstacles to finding a cure for HIV infection.

6 Jun 2014

New targets found for potential intervention in breast cancer

Scientists from the Florida campus of The Scripps Research Institute have found new targets for potential intervention in breast cancer. These new targets could eventually increase effectiveness and reduce the undesirable side effects associated with current treatments.

6 Jun 2014

Device used in physics and chemistry reveals dynamics of pervasive pathogen

If you have it, you probably don't know it. Cytomegalovirus, or CMV, is perhaps one of the biggest pathogens you've never heard of-big, both proportionately and epidemiologically.

6 Jun 2014

Half-life extension technology: an interview with Dermot Pearson, Novozymes Biopharma

A drug's half-life indicates how long a substance will remain active in the body. It is essentially the period of time that it takes for the concentration of the amount of the drug to be reduced by half, and therefore, determines how frequently a drug needs to be administered to maintain its therapeutic effect.

27 May 2014

UNC researchers find new enzyme target for treating chronic pain

Researchers at the UNC School of Medicine have found a new target for treating chronic pain: an enzyme called PIP5K1C.

22 May 2014

New "18F radiotracers" to detect and track certain diseases in patients

Radioactivity is usually associated with nuclear fallout or comic-book spider bites, but in very small amounts it can be a useful tool for diagnosing diseases.

22 May 2014

A novel strategy to uncover new antibiotics

Resistance to antibiotics has been steadily rising, posing a threat to public health. Now, a method from Mohammad Seyedsayamdost, an assistant professor of chemistry at Princeton University, may open the door to the discovery of a host of potential drug candidates.

21 May 2014

Three Chicago-area universities to share research facilities at reduced cost

As research funding from the National Institutes of Health and other federal agencies shrinks, cooperation among Northwestern University, the University of Chicago and the University of Illinois at Chicago is expanding.

20 May 2014

Novozymes Biopharma, ThioLogics to collaborate on drug-albumin conjugation platform

Novozymes Biopharma has entered a new collaboration with UK-based biotechnology company, ThioLogics. The collaboration brings together Novozymes' modified recombinant human albumin (rAlbumin) Veltis technology, with ThioLogics' site-specific next generation maleimide conjugation platform. This allows Novozymes to offer the pharma industry serum stable albumin drug conjugates with enhanced pharmacokinetic and/or targeting capabilities.

14 May 2014

Melbourne researchers find link between necroptosis and inflammatory disease

A team of Melbourne researchers has shown a recently discovered type of cell death called necroptosis could be the underlying cause of inflammatory disease.

13 May 2014

Protein molecule seems to slow progression of deadly lung disease

Researchers at the University of Illinois at Chicago College of Medicine have discovered a protein molecule that seems to slow the progression of pulmonary fibrosis, a progressive lung disease that is often fatal three to five years after diagnosis.

7 May 2014

Researchers create tiny, biodegradable nanoparticles that carry DNA to brain cancer cells

Working together, Johns Hopkins biomedical engineers and neurosurgeons report that they have created tiny, biodegradable “nanoparticles” able to carry DNA to brain cancer cells in mice.

30 Apr 2014

Scientists discover a new process for making fast, efficient crystalline organic semiconductors

Sometimes engineers invent something before they fully comprehend why it works. To understand the "why," they must often create new tools and techniques in a virtuous cycle that improves the original invention while also advancing basic scientific knowledge.

22 Apr 2014

Researchers uncover novel function of Amyloid Precursor Protein linked to Alzheimer's disease

A research team led by the National Neuroscience Institute has uncovered a novel function of the Amyloid Precursor Protein (APP), one of the main pathogenic culprits of Alzheimer's disease. This discovery may help researchers understand how the protein goes awry in the brains of Alzheimer's disease patients, and potentially paves the way for the development of innovative therapeutics to improve the brain function of dementia patients.

22 Apr 2014

Northwestern Medicine study provides new insights on tissue scarring in scleroderma

A discovery by Northwestern Medicine scientists could lead to potential new treatments for breaking the cycle of tissue scarring in people with scleroderma.

21 Apr 2014

Small Molecules News and Research

Single dose restores normal cellular signaling in mouse model of autism

Proteins causing daytime sleepiness also play crucial role in bone formation

New self-assembling nanoparticle arrays can form highly ordered thin film in 1 minute

New targets could increase effectiveness and reduce side effects linked with breast cancer treatments

Brain circuit problem may contribute to auditory hallucinations of schizophrenia

Scientists identify new way to reactivate latent HIV

New targets found for potential intervention in breast cancer

Device used in physics and chemistry reveals dynamics of pervasive pathogen

Half-life extension technology: an interview with Dermot Pearson, Novozymes Biopharma

UNC researchers find new enzyme target for treating chronic pain

New "18F radiotracers" to detect and track certain diseases in patients

A novel strategy to uncover new antibiotics

Three Chicago-area universities to share research facilities at reduced cost

Novozymes Biopharma, ThioLogics to collaborate on drug-albumin conjugation platform

Melbourne researchers find link between necroptosis and inflammatory disease

Protein molecule seems to slow progression of deadly lung disease

Researchers create tiny, biodegradable nanoparticles that carry DNA to brain cancer cells

Scientists discover a new process for making fast, efficient crystalline organic semiconductors

Researchers uncover novel function of Amyloid Precursor Protein linked to Alzheimer's disease

Northwestern Medicine study provides new insights on tissue scarring in scleroderma

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