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Experimental Chinese SARS-CoV-2 vaccine appears safe in early trials

A new study published on the preprint server medRxiv in October 2020 reports the findings of a phase I trial of an inactivated SARS-CoV-2 vaccine, demonstrating that it can elicit a potent immune response without significant adverse reactions.

7 Oct 2020

Plasma ABO protein is a causal risk factor for severe COVID-19

Researchers used an integrative genomics approach to find the genes responsible for COVID-19 and its severity.

7 Oct 2020

Chronic illnesses promote active SARS-CoV-2 infection via suppressed mucosal immunity

A recent paper published in the preprint server medRxiv in September 2020 discusses the “clinically relevant variation in the expression of COVID-19-related genes”, which is associated with the host and environmental factors, as well as host genetic factors.

6 Oct 2020

Another study finds cross-reactivity T cell responses against SARS-CoV-2

Using ELISpot and proliferation assays, researchers show strong responses in SARS-CoV-2 infected patients, but not so much in negative samples. However, there may be cross-reactive T cell responses from other human coronaviruses.

5 Oct 2020

Newly developed fusion protein could improve COVID-19 research

Researchers at the Paul Scherrer Institute in Switzerland have developed a high-quality recombinant virus protein that could be applied in the development of vaccines against the 2019 novel coronavirus (2019-nCoV) and in the detection of novel viruses or antibodies.

30 Sep 2020

Study shows how human cells fight viral infections with the emergence of SARS-CoV-2

Science's pursuits of unraveling how human cells fight viral infections kicked into high gear in 2020 with the devastating emergence of the SARS-CoV-2 virus.

30 Sep 2020

Genetic defects in patients' immune system may underlie severe COVID-19

Worldwide, otherwise healthy adolescents and young people without underlying conditions are sometimes severely affected by COVID-19, with the viral infection in the worst cases quickly becoming life-threatening. But why is this happening?

29 Sep 2020

UCLA researchers receive $13 million NIH grant to combat melanoma

UCLA researchers have received a $13 million grant from the National Institutes of Health to find new ways to overcome melanoma resistance to some of the most promising targeted therapies and immunotherapies.

28 Sep 2020

Life-threatening COVID-19 associated with specific genetic variants

Results of a genome-wide association study on 2,244 critically-ill patients due to coronavirus disease (COVID-19) from 208 intensive care units across the United Kingdom revealed significant host-specific genetic determinants that can predispose people to the severe form of the disease. The report is currently available on the medRxiv preprint server.

28 Sep 2020

Multifunctional cell therapy system raises hopes to treat inflammatory bowel disease

The research by the UPV/EHU-University of the Basque Country, in collaboration with Harvard University, has yielded highly encouraging results, and studies in animal models have already begun

28 Sep 2020

Genetic mutations hinder immune response in severe COVID-19

Now, a truly international team of nearly 140 researchers aimed to determine why some people develop severe illness when once infected by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19 disease.

28 Sep 2020

Auto-antibodies may explain why some people develop severe COVID-19

Now, a new study by an international team of health experts shows that some life-threatening cases of COVID-19 can be traced to specific weak spots in the patients' immune system.

28 Sep 2020

About 10% patients with severe disease create auto-antibodies that attack the immune system

People infected by the novel coronavirus can have symptoms that range from mild to deadly. Now, two new analyses suggest that some life-threatening cases can be traced to weak spots in patients' immune systems.

25 Sep 2020

Faulty genes and an autoimmune condition linked to severe COVID-19 in young, healthy people

More than 10 percent of young and healthy people who develop severe COVID-19 have misguided antibodies that attack not the virus, but the immune system itself, new research shows. Another 3.5 percent, at least, carry a specific kind of genetic mutation.

25 Sep 2020

New studies report specific mechanisms of impaired type I interferon signaling in COVID-19 patients

Two new studies report specific mechanisms of impaired type I interferon (IFN) signaling in some hospitalized patients suffering from severe cases of COVID-19, suggesting that screens for these defects could help identify patients at the highest risk of life-threatening complications from SARS-CoV-2 infection.

25 Sep 2020

Individuals with severe forms of COVID-19 disease can have compromised type I interferon responses

Individuals with severe forms of COVID-19 disease can present with compromised type I interferon (IFN) responses based on their genetics, according to results published in two papers today in the journal Science.

25 Sep 2020

New study may explain why more men than women die from COVID-19

New findings by scientists at the National Institutes of Health and their collaborators help explain why some people with COVID-19 develop severe disease.

25 Sep 2020

AI used to define the cytokine storm implicated in fatal COVID-19

A new study published on the preprint server bioRxiv* in September 2020 reports the use of artificial intelligence (AI) to identify an invariant or universal host immune response found in all viral pandemics so far. The association of this response with severe COVID-19 phenotypes indicates a new understanding of the human immune response in viral pandemics.

24 Sep 2020

HIV drugs cause immune-system changes that can improve resistance to viral infections

Drugs currently used to keep the HIV virus in check also cause immune-system changes that might make humans better able to resist viral infections – but might also cause harmful inflammation, according to a study published today in Cell Reports Medicine.

23 Sep 2020

Children exhibit distinct immune system responses against COVID-19

Children and adults exhibit distinct immune system responses to infection by the virus that causes COVID-19, a finding that helps explain why COVID-19 outcomes tend to be much worse in adults, researchers from Yale and Albert Einstein College of Medicine report Sept. 18 in the journal Science Translational Medicine.

23 Sep 2020

Interferon News and Research

Experimental Chinese SARS-CoV-2 vaccine appears safe in early trials

Plasma ABO protein is a causal risk factor for severe COVID-19

Chronic illnesses promote active SARS-CoV-2 infection via suppressed mucosal immunity

Another study finds cross-reactivity T cell responses against SARS-CoV-2

Newly developed fusion protein could improve COVID-19 research

Study shows how human cells fight viral infections with the emergence of SARS-CoV-2

Genetic defects in patients' immune system may underlie severe COVID-19

UCLA researchers receive $13 million NIH grant to combat melanoma

Life-threatening COVID-19 associated with specific genetic variants

Multifunctional cell therapy system raises hopes to treat inflammatory bowel disease

Genetic mutations hinder immune response in severe COVID-19

Auto-antibodies may explain why some people develop severe COVID-19

About 10% patients with severe disease create auto-antibodies that attack the immune system

Faulty genes and an autoimmune condition linked to severe COVID-19 in young, healthy people

New studies report specific mechanisms of impaired type I interferon signaling in COVID-19 patients

Individuals with severe forms of COVID-19 disease can have compromised type I interferon responses

New study may explain why more men than women die from COVID-19

AI used to define the cytokine storm implicated in fatal COVID-19

HIV drugs cause immune-system changes that can improve resistance to viral infections

Children exhibit distinct immune system responses against COVID-19

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