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Two strains of TB bacterium attack the lungs in completely different fashion, study finds

Two strains of the bacterium causing tuberculosis have only minor genetic differences but attack the lungs in completely different fashion, according to Rutgers researchers.

18 Apr 2022

Effects of COVID-19 treatment best with combination therapy

There is a steadily growing arsenal of drugs for COVID-19. Researchers from Charité – Universitätsmedizin Berlin, the Max Delbrück Center for Molecular Medicine (MDC) and Freie Universität (FU) Berlin have studied the mechanisms of action of antiviral and anti-inflammatory drugs.

15 Apr 2022

Exploring strategies for successful delivery of messenger RNA therapeutics

Researchers reviewed the material properties and administration routes that could successfully deliver a messenger ribonucleic acid therapeutic agent to its targeted site.

14 Apr 2022

Recent advances in non-viral nano-vector delivery of CRISPR/Cas9 genome editing payloads

Researchers reviewed non-viral nano-vectors used for delivering the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9-mediated genome editing system.

14 Apr 2022

New aspergillosis infection model can help better observe the growth of fungus

A chip-based infection model developed by researchers in Jena, Germany, enables live microscopic observation of damage to lung tissue caused by the invasive fungal infection aspergillosis.

13 Apr 2022

Pod-based e-cigarette use alters the inflammatory state across multiple organ systems

Researchers at University of California San Diego School of Medicine report that daily use of pod-based e-cigarettes alters the inflammatory state across multiple organ systems including the brain, heart, lungs and colon. Effects also vary depending on the e-cigarette flavor, and can influence how organs respond to infections, such as SARS-CoV-2.

13 Apr 2022

Silica exposure drives the rising rates of pneumoconiosis in coal workers

Silica exposure is a driving force behind rising rates of coal workers' pneumoconiosis, according to a new study published by occupational health experts at the University of Illinois Chicago and their collaborators.

12 Apr 2022

Dysregulated retroelements associated with autoimmunity in COVID-19

Researchers investigate potential interactions between retro-elements shared between the human and coronavirus genomes.

12 Apr 2022

Researchers construct first single-cell atlas of postnatal lung development in humans and mice

How do the lungs develop after taking their first breaths outside the womb? What cellular events and changes early in life give rise to lung malfunction and disease? To help answer these questions, scientists have constructed the first single-cell atlas of postnatal lung development in humans and mice.

12 Apr 2022

Scientists find critical role for Hippo signaling pathway in COVID-19 pathogenesis

A recent article posted to the bioRxiv* preprint server illustrated that the activation of the Hippo signaling pathway upon severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection aids the host antiviral response.

11 Apr 2022

Prime-pull immunization of mice with novel subunit vaccine elicits mucosal immunity to prevent severe SARS CoV-2 infection

Researchers tested whether a subunit vaccine could generate mucosal immunity in mice and prevent SARS-CoV-2 infection and related pathology.

11 Apr 2022

A novel PLpro inhibitor as a broad-spectrum anti-coronavirus agent

Researchers identify a potentially effective compound against COVID-19 against the SARS-CoV-2 PLpro.

10 Apr 2022

Computational network science approach reveals new mechanisms for coronaviruses infections

A group of bat viruses related to SARS-CoV-2 can also infect human cells but uses a different and unknown entryway.

8 Apr 2022

Yale researchers discover immune response pathway that leads to severe COVID-19

Yale researchers have identified a particular immune response pathway that leads to severe illness and death in people infected by the SARS-CoV-2 virus.

7 Apr 2022

Researchers reveal why people with allergic asthma are protected from severe COVID

The vast majority of people infected with the omicron variant of SARS-CoV-2 experience mild cold-like symptoms, moderate flu-like symptoms, or no symptoms at all, but the virus is so transmissible that it still spread deep into lung tissue to cause severe disease and death in thousands of people in the United States in 2022 alone.

7 Apr 2022

Study investigates biochemical, biophysical, and immunological profile of COVID-19 respiratory secretions

A new study assessed the biophysical, immunological, and biochemical characteristics of respiratory secretions in acute SARS-CoV-2 infections.

7 Apr 2022

Insights into the pathogenesis of the previous and circulating SARS-CoV-2 variants in mice

A recent article presented the diverse pathogenesis of SARS-CoV-2 variants of concern in a humanized mouse model.

7 Apr 2022

A shortfall of ECMO treatment cost lives during the delta surge

Speaking from his hospital bed at Vanderbilt University Medical Center in Nashville, Tennessee, James Perkinson’s voice was raspy. In February, he’d just been taken off ECMO, the last-ditch life support treatment in which a machine outside the body does the work of the heart and lungs.

7 Apr 2022

Transcriptional reprogramming of monocytes in COVID-19

In a recent study posted to the bioRxiv* server, researchers examined the functionality of cluster of differentiation 14-positive (CD14+) monocytes in patients with mild or moderate coronavirus disease 2019 (COVID-19).

7 Apr 2022

New insights on lung surfactants could lead to better treatments for respiratory illnesses

A team led by University of Minnesota Twin Cities engineering researchers analyzed the fundamental properties and structures of lung surfactant-;a naturally occurring substance that helps human and animal lungs expand and contract-;providing insight that could eventually help scientists develop better treatments for respiratory illnesses.

6 Apr 2022

Lungs News and Research

Two strains of TB bacterium attack the lungs in completely different fashion, study finds

Effects of COVID-19 treatment best with combination therapy

Exploring strategies for successful delivery of messenger RNA therapeutics

Recent advances in non-viral nano-vector delivery of CRISPR/Cas9 genome editing payloads

New aspergillosis infection model can help better observe the growth of fungus

Pod-based e-cigarette use alters the inflammatory state across multiple organ systems

Silica exposure drives the rising rates of pneumoconiosis in coal workers

Dysregulated retroelements associated with autoimmunity in COVID-19

Researchers construct first single-cell atlas of postnatal lung development in humans and mice

Scientists find critical role for Hippo signaling pathway in COVID-19 pathogenesis

Prime-pull immunization of mice with novel subunit vaccine elicits mucosal immunity to prevent severe SARS CoV-2 infection

A novel PLpro inhibitor as a broad-spectrum anti-coronavirus agent

Computational network science approach reveals new mechanisms for coronaviruses infections

Yale researchers discover immune response pathway that leads to severe COVID-19

Researchers reveal why people with allergic asthma are protected from severe COVID

Study investigates biochemical, biophysical, and immunological profile of COVID-19 respiratory secretions

Insights into the pathogenesis of the previous and circulating SARS-CoV-2 variants in mice

A shortfall of ECMO treatment cost lives during the delta surge

Transcriptional reprogramming of monocytes in COVID-19

New insights on lung surfactants could lead to better treatments for respiratory illnesses

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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