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FDA issues a Complete Response Letter for Human Genome Sciences' raxibacumab BLA

Human Genome Sciences, Inc. today announced that it has received a Complete Response Letter from the U.S. Food and Drug Administration (FDA) relating to the Company’s Biologics License Application (BLA) requesting the approval of raxibacumab for use in the treatment of inhalational anthrax. The FDA issues Complete Response Letters to request additional information needed to complete the review of a BLA.

16 Nov 2009

Second Consumer Genetics Conference to be hosted at the Hynes Convention Center

The media spotlight will shine again on Boston from June 2nd – June 4th, 2010 as the Consumer Genetics Conference, (www.consumergeneticsconference.com), hosts its yearly conference at the Hynes Convention Center.

16 Nov 2009

Cytoskeleton plays a critical role to bring chromosome pairs together: Study

Meiosis - the pairing and recombination of chromosomes, followed by segregation of half to each egg or sperm cell - is a major crossroads in all organisms reproducing sexually. Yet, how the cell precisely choreographs these chromosomal interactions is a long-standing question.

16 Nov 2009

Research team identifies five new gene regions that raise the risk of childhood-onset IBD

In the largest, most comprehensive genetic analysis of childhood-onset inflammatory bowel disease (IBD), an international research team has identified five new gene regions, including one involved in a biological pathway that helps drive the painful inflammation of the digestive tract that characterizes the disease.

16 Nov 2009

Scientists describe how HIV assemble at the membrane of infected cells and are released to attack healthy cells

Although recent advances have raised hopes that a protective vaccine can be developed, acquired immunodeficiency syndrome (AIDS) remains a major public health problem. Much has been learned about HIV-1, the virus that causes the disease.

13 Nov 2009

New gene therapy may breach the armor of cancerous tumors

The seeming invincibility of cancerous tumors may be crumbling, thanks to a promising new gene therapy that eliminates the ability of certain cells to repair themselves. Researchers at the Cornell University College of Veterinary Medicine have discovered that inactivation of a DNA repair gene called Hus1 efficiently kills cells lacking p53 -- a gene mutated in the majority of human cancers.

13 Nov 2009

New findings on human genome may be useful for developing specific AIDS drugs

The AIDS virus inserts its genetic material into the genome of the infected cell. Scientists of the German Cancer Research Center have now shown for the first time that the virus almost entirely spares particular sites in the human genetic material in this process. This finding may be useful for developing new, specific AIDS drugs.

13 Nov 2009

Stapled Peptides directly inhibit the Notch transcription factor complex

Aileron Therapeutics, a biopharmaceutical company leading the development of a new class of drugs called Stapled Peptides, announced today that its collaborators, James E. Bradner, MD of the Dana-Farber Cancer Institute and the Broad Institute of Harvard and MIT, and Gregory L. Verdine, PhD, Professor of Chemistry at Harvard University, published research in Nature entitled, “Direct Inhibition of the Notch Transcription Factor Complex.”

12 Nov 2009

Stapled Peptides can inhibit key intracellular biological targets, says new research

Aileron Therapeutics, a biopharmaceutical company leading the development of a new class of drugs called Stapled Peptides, announced today that its collaborators, James E. Bradner, MD of the Dana-Farber Cancer Institute and the Broad Institute of Harvard and MIT, and Gregory L. Verdine, PhD, Professor of Chemistry at Harvard University, published research in Nature entitled, "Direct Inhibition of the Notch Transcription Factor Complex." Results presented in the paper showed that Stapled Peptides can potently and directly inhibit the transcription factor Notch, an oncogene implicated in cancer cell proliferation and survival.

12 Nov 2009

Scientists find way to disarm "undruggable" protein; discovery lays foundation for new kind of cancer therapy

Scientists have devised an innovative way to disarm a key protein considered to be "undruggable," meaning that all previous efforts to develop a drug against it have failed. Their discovery, published in the November 12 issue of Nature, lays the foundation for a new kind of therapy aimed directly at a critical human protein — one of a few thousand so-called transcription factors — that could someday be used to treat a variety of diseases, especially multiple types of cancer.

12 Nov 2009

First draft of the cassava genome complete

A team of academic, government and industry researchers has completed a first draft of the cassava (Manihot esculenta) genome. The project is an important first step in accelerating the pace of research on this subsistence crop and addressing some of the many limitations that face cassava farmers around the world.

11 Nov 2009

Scarab Genomics reduces the E. coli K-12 genome, optimizing it for recombinant DNA and protein production

Scarab Genomics has made a series of planned, precise deletions to the E. coli K-12 genome, reducing the genome by more than 15%. The multiple-deletion series (MDS™) strains eliminate non-essential genes, cryptic virulence genes, and sequences of recombinogenic and mobile insertion sequence (IS) DNA, while preserving robust growth in rich and minimal media.

10 Nov 2009

AMP's four-day event on the latest advances in clinical molecular diagnostics

The Association for Molecular Pathology (AMP) invites the media to follow its upcoming 2009 Annual Meeting and Exhibits and learn about the latest advances in clinical molecular diagnostics.

10 Nov 2009

UCSD findings may help scientists to design better drugs to kill pathogenic strains

Over the last 20 years, the sequencing of the human genome, along with related organisms, has represented one of the largest scientific endeavors in the history of mankind. The information collected from genome sequencing will provide the raw data for the field of bioinformatics, where computer science and biology meet.

10 Nov 2009

Researcers identify a new array of genes in GAS

Group A streptococcus (GAS) is a human pathogenic bacteria. Many people carry GAS asymptomatically in their upper respiratory tract and other anatomic sites. However, these bacteria can cause a variety of human diseases ranging from superficial skin and throat infections to highly invasive life-threatening diseases such as toxic shock and necrotizing fasciitis, commonly known as the flesh-eating bacteria.

10 Nov 2009

Compugen discovers new biomarker for predisposition to type 2 diabetes using its GeneVa platform

Compugen Ltd. announced today the discovery and experimental confirmation of a genetic biomarker, CGEN-40001 for predisposition to type 2 diabetes, the most common form of diabetes.

9 Nov 2009

Researchers discover a fungal protein that causes disease in plants and animals

Researchers at the Virginia Bioinformatics Institute (VBI) at Virginia Tech and Montana State University have discovered a fungal protein that plays a key role in causing disease in plants and animals and which also shields the pathogen from oxidative stress.

7 Nov 2009

Broad Institute purchases 30 additional Genome Analyzers from Illumina

Illumina, Inc. today announced that the Broad Institute has purchased 30 additional Genome Analyzers, increasing its total installed base of Illumina systems to 89.

From Illumina, Inc. 6 Nov 2009

Scientists receive $3 million from NIH to uncover how plants make medicinal compounds

Scientists at Michigan State University are receiving nearly $3 million from the National Institutes of Health to uncover how several popular plants make medicinal compounds.

6 Nov 2009

Complete Genomics publishes sequence analysis data from three complete human genomes

Complete Genomics, a third-generation human genome sequencing company, today announced publication of a report in the journal Science describing its proprietary DNA sequencing platform, including analysis of sequence data from three complete human genomes. The consumables cost for these three genomes sequenced on the proof-of-principle genomic DNA nanoarrays ranged from $8,005 for 87x coverage to $1,726 for 45x coverage for the samples described in this report.

6 Nov 2009

Genome News and Research

FDA issues a Complete Response Letter for Human Genome Sciences' raxibacumab BLA

Second Consumer Genetics Conference to be hosted at the Hynes Convention Center

Cytoskeleton plays a critical role to bring chromosome pairs together: Study

Research team identifies five new gene regions that raise the risk of childhood-onset IBD

Scientists describe how HIV assemble at the membrane of infected cells and are released to attack healthy cells

New gene therapy may breach the armor of cancerous tumors

New findings on human genome may be useful for developing specific AIDS drugs

Stapled Peptides directly inhibit the Notch transcription factor complex

Stapled Peptides can inhibit key intracellular biological targets, says new research

Scientists find way to disarm "undruggable" protein; discovery lays foundation for new kind of cancer therapy

First draft of the cassava genome complete

Scarab Genomics reduces the E. coli K-12 genome, optimizing it for recombinant DNA and protein production

AMP's four-day event on the latest advances in clinical molecular diagnostics

UCSD findings may help scientists to design better drugs to kill pathogenic strains

Researcers identify a new array of genes in GAS

Compugen discovers new biomarker for predisposition to type 2 diabetes using its GeneVa platform

Researchers discover a fungal protein that causes disease in plants and animals

Broad Institute purchases 30 additional Genome Analyzers from Illumina

Scientists receive $3 million from NIH to uncover how plants make medicinal compounds

Complete Genomics publishes sequence analysis data from three complete human genomes

eBook: A guide to RNA sequencing eBook

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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