Lungs News and Research

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Testes found to be a viral reservoir for SARS-CoV-2 replication

In a recent study posted to the medRxiv* pre-print server, researchers used a suite of methods to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the testis of patients who died from coronavirus disease 2019 (COVID-19) to gain insights into SARS-CoV-2 tropism inside testis and its impact on male fertility.

13 Feb 2022

Hollings researcher receives grant to fight complications after pediatric bone marrow transplant

MUSC Hollings Cancer Center researcher Sophie Paczesny, M.D., Ph.D., recently received a four-year grant from the National Heart, Lung, and Blood Institute to investigate solutions to help doctors to fight complications after pediatric bone marrow transplantation (BMT).

12 Feb 2022

Study points to vagus nerve dysfunction as a central pathophysiological feature of long COVID

New research to be presented at this year's European Congress of Clinical Microbiology and Infectious Diseases (ECCMID 2022, Lisbon, 23-26 April) suggests that many of the symptoms connected to post-COVID syndrome (PCC, also known as long COVID) could be linked to the effect of the virus on the vagus nerve – one of the most important multi-functional nerves in the body.

12 Feb 2022

Cells self-organize to generate forces that model the shapes of tissues

A team from the UNIGE has demonstrated that cells self-organise to generate forces that model the shapes of our tissues.

12 Feb 2022

COPD patients more compliant with COVID-19 restrictions in the UK

A new study reports on the tendency among COPD patients in the UK to practice social distancing, compared to the public at large, during the COVID-19 pandemic.

11 Feb 2022

Newer clot-busting drug may lengthen the window for additional stroke treatment to 24 hours

If patients with clot-caused strokes obtain medical care more than 4½ hours after their symptoms are noticed, it is too late to receive the standard clot-busting medication alteplase.

11 Feb 2022

Study: Almost a third of older adults infected with covid-19 develop new conditions

Almost a third (32 of every 100) of older adults infected with covid-19 in 2020 developed at least one new condition that required medical attention in the months after initial infection, 11 more than those who did not have covid-19, finds a US study published by The BMJ today.

10 Feb 2022

Screening assays identify TMPRSS2 inhibitors from drug repurposing candidates useful as COVID-19 therapeutic

Researchers used an assay toolset for discovering new transmembrane protease serine 2 inhibiting drug repurposing candidates, that can be useful as therapeutics for COVID-19 treatment.

10 Feb 2022

Protective efficacy of BNT162b2 and Ad26.COV2.S against SARS-CoV-2 Omicron challenge in nonhuman primates

The study highlights the significance of mix-and-match vaccine regimens to diversify the immune responses against highly mutated variants of SARS-CoV-2 such as Omicron.

10 Feb 2022

Omicron resists antibodies, causes less severe disease than previous SARS-CoV-2variants

In two recent studies, researchers at Washington University School of Medicine in St. Louis found evidence that the omicron variant of the virus that causes COVID-19 causes less severe disease than previous variants — at least in rodents — but that many antibody-based therapies may not be effective against it.

10 Feb 2022

Study tests efficacy of molnupiravir against SARS-CoV-2 VOCs in various animal models

A study published on the bioRxiv* preprint server evaluates molnupiravir against a panel of relevant VOCs using three efficacy models: primary human airway epithelium organoids, a ferret model of upper respiratory disease, and a Roborovski dwarf hamster model for severe COVID-19.

9 Feb 2022

How SARS-CoV-2 infection progresses throughout the respiratory system

Researchers discuss the progression of SARS-CoV-2 infection throughout the respiratory epithelium.

9 Feb 2022

Single-cell sequencing provides detailed insight into early SARS-CoV-2 infection in the lungs

What is going on at the single-cell level in the first days of SARS-CoV-2 infection in the lungs?

9 Feb 2022

30-year-old cancer drug could get another shot, study says

A study by Virginia Commonwealth University Massey Cancer Center researchers published in today's print edition of Molecular Cancer Therapeutics shows that triplatin is effective against triple negative breast cancer, which is the most aggressive form of breast cancer and has few targeted therapies.

9 Feb 2022

Old FDA-approved drug may protect against lung injury and blood clots in severe COVID-19

An FDA-approved drug that has been in clinical use for more than 70 years may protect against lung injury and the risk of blood clots in severe COVID-19 and other disorders that cause immune-mediated damage to the lungs, according to a preclinical study from researchers at Weill Cornell Medicine and Cold Spring Harbor Laboratory.

8 Feb 2022

FDA-approved drug prevents the immune system from producing neutrophil extracellular traps

A team of scientists led by Cold Spring Harbor Laboratory (CSHL) have discovered that disulfiram, an FDA-approved drug, prevents the immune system from producing toxic webs known as neutrophil extracellular traps (NETs).

8 Feb 2022

UTSA awarded $6.8 million grant to establish a Coccidioidomycosis Collaborative Research Center

Mycology and immunology researchers from The University of Texas at San Antonio have been selected to receive a five-year, $6.8 million grant from the National Institutes of Health to establish a San Antonio-based Coccidioidomycosis Collaborative Research Center (SA-CCRC) focused on developing therapeutics and vaccines against coccidioidomycosis.

8 Feb 2022

Study shows chronic alcohol consumption as a potential risk factor for SARS-CoV-2-infection

In a study posted to the bioRxiv* preprint server, a team of researchers from Germany studied the expression data of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection-relevant genes such as angiotensin-converting enzyme 2 (ACE2), transmembrane serine protease 2 (TMPRSS2), and the G-protein coupled receptor Mas in an alcohol-exposed rodent model infected with SARS-CoV-2.

7 Feb 2022

mRNA-based COVID-19 booster vaccination shown to protect against severe omicron infection in macaques

Scientists recently evaluated the effectiveness of a booster dose of the Moderna-developed COVID-19 vaccine and omicron spike-specific mRNA vaccine in non-human primates that are primed with the Moderna vaccine.

7 Feb 2022

Understanding how COVID-19 infection spreads from the upper airways to the lungs

Whether COVID-19 becomes a life-threatening disease depends, in part, on the virus reaching one's lungs. Scientists suspect the initial infected tissues in the upper airway can act as the source for virus-laden droplets or boluses, that are aspirated into the lungs.

4 Feb 2022

Lungs News and Research

Testes found to be a viral reservoir for SARS-CoV-2 replication

Hollings researcher receives grant to fight complications after pediatric bone marrow transplant

Study points to vagus nerve dysfunction as a central pathophysiological feature of long COVID

Cells self-organize to generate forces that model the shapes of tissues

COPD patients more compliant with COVID-19 restrictions in the UK

Newer clot-busting drug may lengthen the window for additional stroke treatment to 24 hours

Study: Almost a third of older adults infected with covid-19 develop new conditions

Screening assays identify TMPRSS2 inhibitors from drug repurposing candidates useful as COVID-19 therapeutic

Protective efficacy of BNT162b2 and Ad26.COV2.S against SARS-CoV-2 Omicron challenge in nonhuman primates

Omicron resists antibodies, causes less severe disease than previous SARS-CoV-2variants

Study tests efficacy of molnupiravir against SARS-CoV-2 VOCs in various animal models

How SARS-CoV-2 infection progresses throughout the respiratory system

Single-cell sequencing provides detailed insight into early SARS-CoV-2 infection in the lungs

30-year-old cancer drug could get another shot, study says

Old FDA-approved drug may protect against lung injury and blood clots in severe COVID-19

FDA-approved drug prevents the immune system from producing neutrophil extracellular traps

UTSA awarded $6.8 million grant to establish a Coccidioidomycosis Collaborative Research Center

Study shows chronic alcohol consumption as a potential risk factor for SARS-CoV-2-infection

mRNA-based COVID-19 booster vaccination shown to protect against severe omicron infection in macaques

Understanding how COVID-19 infection spreads from the upper airways to the lungs

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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