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Gleevec receives FDA priority review for gastrointestinal stromal tumors after surgery

Novartis has announced that Gleevec (imatinib mesylate) tablets, (known as Glivec (imatinib) outside the US, Canada and Israel), has been granted priority review status by the US Food and Drug Administration (FDA) as the first therapy to be reviewed for use after surgery in kit-positive gastrointestinal stromal tumors (GIST).

27 Aug 2008

Potential new targets for antidepressants

The news about antidepressant medications over the past several years has been mixed. The bad news from large multicenter studies such as STAR*D is that current antidepressant medications are effective, but not as effective as one might hope. Thus, there is a significant need for new treatment mechanisms for depression. On that front, there has been mixed news as well.

27 Aug 2008

Breastfeeding, other factors may affect risk of breast cancer type

Factors such as age at menopause as well as a woman's breastfeeding practices can influence her risk of developing certain types of breast cancer. That was the conclusion of a new study published in the October 1, 2008 issue of CANCER, a peer-reviewed journal of the American Cancer Society. The study's results suggest that there are distinct and separate hormonal risk factors associated with different subtypes of breast cancer.

25 Aug 2008

Researchers discover key allergy gene

Together with colleagues from the Department of Dermatology and Allergy and the Center for Allergy and Environment (ZAUM) of the Technische Universitat Munchen, scientists at the Helmholtz Zentrum Munchen have pinpointed a major gene for allergic diseases. The gene was localized using cutting edge technologies for examining the whole human genome at the Helmholtz Zentrum Munchen.

24 Aug 2008

New vaccine to fight multiple influenza strains

A universal vaccine effective against several strains of influenza has passed its first phase of testing, according to Dr. Christine Turley of the University of Texas at Galveston.

21 Aug 2008

Why hormone therapy for prostate cancer fails

Some of the drugs given to many men during their fight against prostate cancer can actually spur some cancer cells to grow, researchers have found. The findings were published online this week in a pair of papers in the Proceedings of the National Academy of Sciences.

21 Aug 2008

Scientists uncover molecule that keeps pathogens like salmonella in check

Scientists at UT Southwestern Medical Center have found a potential new way to stop the bacteria that cause gastroenteritis, tularemia and severe diarrhea from making people sick.

21 Aug 2008

Discovery of major genetic cause of colorectal cancer

About one-third of colorectal cancers are inherited, but the genetic cause of most of these cancers is unknown. The genes linked to colorectal cancer account for less than 5 percent of all cases.

14 Aug 2008

Blood pressure response to daily stress provides clues for better hypertension treatment

How the body regulates blood pressure in response to daily stress is the focus of a study geared toward helping people whose pressure is out of control.

14 Aug 2008

Universal gene signaling mechanism identified by UB molecular researchers

A novel gene signaling mechanism that controls whether a stem cell develops into its destined tissue or fails to differentiate and becomes cancer has been identified by researchers in the multi-laboratory Molecular and Structural Neurobiology and Gene Therapy Program based at the University at Buffalo.

14 Aug 2008

Molecular switch provides insights into a form of altered brain activity occurring in schizophrenia

People with schizophrenia have an alteration in a pattern of brain electrical activity associated with learning and memory. Now, researchers from the National Institutes of Health and Sweden's Karolinska Institute have identified in mouse brain tissue a molecular switch that, when thrown, increases the strength of this electrical pattern. The researchers found that adding the brain chemical Neuregulin-1 to the brain tissue boosted the electrical signals that the tissue generated.

13 Aug 2008

Risk of breast cancer recurring even after 5 years of therapy

New research has found that even after 5 years of systemic therapy, breast cancer patients still have a substantial risk of the disease recurring.

13 Aug 2008

Breast cancer patients still have risk of relapse after 5 years of systemic therapy

Breast cancer survivors continue to have a substantial risk of disease recurrence after five years of systemic therapy, according to a study published in the August 12 online issue of the Journal of the National Cancer Institute.

12 Aug 2008

Therapies which boost the clearance of faulty proteins in cells may slow down ageing

Scientists say as people age, their cells become less efficient at getting rid of damaged protein and the result is a buildup of toxic material; this is particularly apparent in Alzheimer's, Parkinson's disease and other neurodegenerative disorders associated with ageing.

11 Aug 2008

New treatment in the pipeline for leukaemia and rheumatoid arthritis

Australian scientists believe they are well on the way to developing a new treatment for leukaemia and inflammatory diseases such as rheumatoid arthritis and asthma.

10 Aug 2008

Scientists stop age-related decline in an entire organ

As people age, their cells become less efficient at getting rid of damaged protein - resulting in a buildup of toxic material that is especially pronounced in Alzheimer's, Parkinson's disease, and other neurodegenerative disorders.

10 Aug 2008

First cigarette "buzz", addiction linked to gene

Anyone who has ever tried smoking probably remembers that first cigarette vividly. For some, it brought a wave of nausea or a nasty coughing fit. For others, those first puffs also came with a rush of pleasure or "buzz."

10 Aug 2008

New therapeutic platform technology tackles major diseases

A spin out company from basic structural biology, Asterion Ltd., has led to new technology that provides a way of creating therapeutic proteins to tackle major diseases such as cancer, diabetes and infertility.

8 Aug 2008

New understanding on how Chilli peppers increase metabolism and body temperature

Chilli peppers can do more than just make you feel hot, reports a study in the August 1 Journal of Biological Chemistry; the active chemical in peppers can directly induce thermogenesis, the process by which cells convert energy into heat.

6 Aug 2008

Findings may aid in bone marrow transplants, blood diseases

New research sheds light on the biological events by which stem cells in the bone marrow develop into the broad variety of cells that circulate in the blood. The findings may help improve the success of bone marrow transplants and develop better treatments for life-threatening blood diseases.

5 Aug 2008