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Rheumatoid arthritis genes

A paper published this week in the open access journal PLoS Medicine provides strong evidence that one specific part of the genome is associated with rheumatoid arthritis.

18 Sep 2007

New understanding of gene mutation responsible for fragile X syndrome

Scientists have discovered how the gene mutation responsible for fragile X syndrome - the most common inherited form of mental retardation - alters the way brain cells communicate.

18 Sep 2007

High fat diet and exercise stimulate the breakdown of fats

Scientists report in the October issue of the Journal of Lipid Research that when either lean or obese individuals exercise after eating a high fat meal, their fats are broken down and oxidized in skeletal muscle, making them healthier.

18 Sep 2007

Circulating fats kill transplanted pancreas cells

New findings by UT Southwestern Medical Center researchers show that a byproduct of cholesterol metabolism interferes with the beneficial effects estrogen has on the cardiovascular system, providing a better understanding of the interplay between cholesterol and estrogen in heart disease.

18 Sep 2007

LL37 peptide provides a new potential target for autoimmune disease

A human peptide that acts as a natural antibiotic against invading microbes can also bind to the body's own DNA and trigger an immune response in the absence of an infection, a research team led by scientists at The University of Texas M. D. Anderson Cancer Center reports in an early online publication in Nature.

17 Sep 2007

TFAP2C gene may be useful target for new breast cancer therapies

University of Iowa researchers have discovered a gene that plays a linchpin role in the ability of breast cancer cells to respond to estrogen.

17 Sep 2007

Genetic variant explains why people react differently to smells

Why the same sweaty man smells pleasant to one person and repellant to another comes down to the smeller's genes.

17 Sep 2007

Androstenone determines whether male body odor smells pleasant

New research from Rockefeller University, performed in collaboration with scientists at Duke University in North Carolina, reveals for the first time that this extreme variability in peopl's perception of androstenone is due in large part to genetic variations in a single odorant receptor called OR7D4.

17 Sep 2007

Evista (raloxifene hydrochloride) approved for breast cancer

The U.S. Food and Drug Administration today approved Evista (raloxifene hydrochloride) for reducing the risk of invasive breast cancer in postmenopausal women with osteoporosis and in postmenopausal women at high risk for invasive breast cancer.

17 Sep 2007

Byproduct of cholesterol metabolism blocks heart health benefits of estrogen

17 Sep 2007

Byproduct of cholesterol interferes with the beneficial effects of estrogen on the heart

A new study possibly offers a biological reason why hormone replacement therapy (HRT) fails to protect some postmenopausal women from heart disease.

17 Sep 2007

Study suggests brain tumors need treatment with multiple 'targeted' drugs

Researchers at Dana-Farber Cancer Institute have shown that several, rather than just one, cell-growth switches are simultaneously overactive in many brain tumors and other solid tumors, explaining why treatment with just a single "targeted" switch-blocking drug often yields disappointing results.

13 Sep 2007

Reducing enlarged heart decreases risk of heart failure

For high-blood-pressure patients, preventing or reducing enlarged heart (left ventricular hypertrophy or LVH) reduces risk of heart failure.

13 Sep 2007

Platelets help white blood cells fight inflammation

Scientists have shown for the first time that platelets, the cells needed for blood clotting, help white blood cells called neutrophils fight inflammation.

13 Sep 2007

New technique detects how proteins undergo changes inside a cell

In the September issue of Molecular & Cellular Proteomics , scientists describe a new technique that can detect how proteins undergo changes inside a cell.

13 Sep 2007

Insight into the role of cancer stem cells in cancer initiation, progression and metastasis

Scientists have identified a distinct subpopulation of cancer stem cells (CSCs) that is responsible for metastasis of a deadly human pancreatic cancer.

13 Sep 2007

New insights into retinal growth

Peering at microscopic changes within the retina, scientists in the Department of Ophthalmology at Weill Cornell Medical College in New York City, have discovered a key mechanism driving eye health and eye disease.

12 Sep 2007

New insight into breast cancer development in high-risk women

Physicians who treat women with the breast cancer susceptibility gene BRCA1 often remove their patients' ovaries to eliminate the source of estrogen they believe fuels cancer growth.

12 Sep 2007

Preventing enlarged heart reduces heart failure

For high-blood-pressure patients, preventing or reducing enlarged heart (left ventricular hypertrophy or LVH) reduces risk of heart failure. The study is published in the Sept. 4 Annals of Internal Medicine and led by physician-scientists at NewYork-Presbyterian Hospital/Weill Cornell Medical Center in New York City.

11 Sep 2007

Sugar key to malaria parasite invasion

Researchers at the Johns Hopkins Malaria Research Institute (JHMRI) have identified a sugar in mosquitoes that allows the malaria-causing parasite, Plasmodium falciparum, to attach itself to the mosquito's gut.

11 Sep 2007