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Increasing SUMO protein in brain could be a way of treating epilepsy and schizophrenia

The brain contains about 100 million nerve cells, each having 10,000 connections to other nerves cells. These connections, called synapses, chemically transmit the information that controls all brain function via proteins called receptors. These processes are believed to be the basis of learning and memory.

7 May 2007

Nitric oxide may be the key to why specific drugs for heart failure or asthma lose their effectiveness over time

A naturally occurring molecule in the body appears to control whether certain medications, such as beta adrenergic receptor agonists used in acute heart failure or in inhalers for asthma, lose their effectiveness over time.

4 May 2007

Renewal of Echinacea and St John's Wort research

A five-year-old research center dedicated to understanding and improving Echinacea and Hypericum perforatum (St. John's wort) has received $4.4 million in continuation funding from the National Institutes of Health. The renewal is for three years.

4 May 2007

Cause of gender differences in high blood pressure and related kidney disease

While men and women both get high blood pressure and related kidney disease, the path to get there is shorter, steeper and just different for men, researchers say.

4 May 2007

Infliximab fails to improve chronic obstructive pulmonary disease symptoms

A promising anti-inflammatory drug failed to improve symptoms of moderate to severe chronic obstructive pulmonary disease, or COPD, in a large, multi-center trial.

2 May 2007

Magnesium loss In patients given monoclonal antibodies

97% of patients with cancer treated with monoclonal antibodies—cetuximab, matuzumab, or panitumumab—that target the epidermal growth factor receptor (EGFR) have some degree of magnesium loss (hypomagnesaemia), according to a study published in the May issue of The Lancet Oncology.

2 May 2007

New compounds show potential for cognitive disorders

UC Irvine researchers have identified a new class of compounds that could be used for drugs to treat cognitive disorders that accompany schizophrenia, Alzheimer's disease and ADHD, according to an article published today in the online version of the Proceedings of the National Academy of Sciences.

2 May 2007

Why do some people get fat even when they eat relatively little?

What creates that irresistible urge for a bag of potato chips or a hunk of chocolate cake, as opposed to a nice crisp apple? Can food urges be irresistible?

2 May 2007

Combination treatment cures mice of a very aggressive human breast tumor

A combination of three different drugs that block the HER-2 receptor, a critical cellular growth signal for some breast cancers, eradicated aggressive breast tumors in mice and could point the way toward developing better treatments inpatients, said researchers from the Breast Center at Baylor College of Medicine in a report that appears today in the Journal of the National Cancer Institute.

2 May 2007

Traditional African medicines may hold potential for treating high blood pressure

Medicinal plants are an integral part of African culture, one of the oldest and most diverse in the world.

2 May 2007

Smelling for first time results from knowing abnormalities in congenital loss of smell

New discoveries about the biochemical basis of the majority of cases of the congenital inability to smell any odor, no matter how strong, have enabled their discoverer, Dr. Robert I. Henkin, director of The Taste and Smell Clinic in Washington, DC, to treat such patients, enabling them to smell something for the first time in their lives.

1 May 2007

Caution against over-aggressive use of erythropoiesis-stimulating agents for cancer-related anemia

Echoing recent FDA warnings, a research group from Northern Ireland cautions against over-aggressive use of a group of drugs called "erythropoiesis-stimulating agents" (ESAs) to treat anemia in some cancer patients, according to a commentary in the April issue of The Oncologist, published by AlphaMed Press.

1 May 2007

Submission of NDA for Istradefylline(KW-6002), an investigational anti-Parkinson's disease drug

Kyowa Hakko Kogyo Co. has announced that Kyowa Pharmaceutical, Inc., its wholly owned U.S subsidiary, submitted on April 25, 2007 a new drug application (NDA) to the U.S. Food and Drug Administration (FDA) for Istradefylline(KW-6002), its investigational drug for Parkinson's disease.

30 Apr 2007

Chronic alcohol consumption increases tumor growth and amgiogenesis of breast cancer in female mice

For the first time, scientists have used a laboratory mouse model to mimic the development of human alcohol-induced breast cancer.

30 Apr 2007

Leptin shown to significantly influence breast cancer development

Being obese increases the risk of breast cancer in post-menopausal women, shortens the time between return of the disease and lowers overall survival rates.

30 Apr 2007

New mechanism identified for resistance to targeted lung cancer drugs

An international research team, led by investigators from the Massachusetts General Hospital (MGH) Cancer Center and Dana-Farber Cancer Institute (DFCI), has found a new way that some lung tumors become resistant to treatment with targeted therapy drugs like Iressa and Tarceva.

27 Apr 2007

Receptor News and Research

Increasing SUMO protein in brain could be a way of treating epilepsy and schizophrenia

Nitric oxide may be the key to why specific drugs for heart failure or asthma lose their effectiveness over time

Renewal of Echinacea and St John's Wort research

Cause of gender differences in high blood pressure and related kidney disease

Infliximab fails to improve chronic obstructive pulmonary disease symptoms

Magnesium loss In patients given monoclonal antibodies

New compounds show potential for cognitive disorders

Why do some people get fat even when they eat relatively little?

Combination treatment cures mice of a very aggressive human breast tumor

Traditional African medicines may hold potential for treating high blood pressure

Smelling for first time results from knowing abnormalities in congenital loss of smell

Caution against over-aggressive use of erythropoiesis-stimulating agents for cancer-related anemia

Submission of NDA for Istradefylline(KW-6002), an investigational anti-Parkinson's disease drug

Chronic alcohol consumption increases tumor growth and amgiogenesis of breast cancer in female mice

Leptin shown to significantly influence breast cancer development

New mechanism identified for resistance to targeted lung cancer drugs

Genetic differences may explain why many Asian women who never smoked develop lung cancer

Drugs that adjust dopamine levels in the brain greatly affect how people react to success and failure

Influence of the cellular microenvironment on breast cancer

Mice on Prozac may help improve serotonin-based antidepressants

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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